Exhibit 99
For immediate release: Contact: Andy McCormick
January 22, 2003 212-573-1226
PFIZER ANNOUNCES STRONG FOURTH-QUARTER AND FULL-YEAR 2002 RESULTS
FORESEES STRONG PERFORMANCE IN 2003
Fourth-Quarter Revenues Grew 14 Percent to $9.333 Billion,
Full-Year Revenues Increased 12 Percent to $32.373 Billion
Reported Fourth-Quarter Diluted EPS Increased 53 Percent to $.46, Reported
Full-Year Diluted EPS Up 20 Percent to $1.46
Fourth-Quarter Diluted EPS, Excluding Certain Significant Items, Merger-
Related Costs, and Cumulative Effect of Change in Accounting Principle,
Grew 45 Percent to $.48;
Full-Year Diluted EPS Up 21 Percent to $1.59, on Same Basis
Implementation Planning for Pharmacia Acquisition Largely Complete, Closing
Still Expected During First Quarter of 2003
Note: Pfizer has sold the Tetra fish-care-products business, has announced
the sale of the Adams confectionery-products business and the Schick-
Wilkinson Sword shaving-products business, and has made decisions to divest
the FemHRT, Loestrin, and Estrostep women's health product lines. The
following fourth-quarter and full-year results reflect these businesses and
product lines as discontinued operations. As a result, all revenues and
expenses of these businesses and products have been eliminated from income
from continuing operations before cumulative effect of a change in accounting
principle in Pfizer's consolidated statement of income and are reflected as
discontinued operations -- net of tax for both 2002 and 2001.
NEW YORK, January 22 -- Pfizer Inc today reported (under generally accepted
accounting principles) that fourth-quarter revenues grew 14 percent to $9.333
billion. Reported net income in the fourth quarter increased 46 percent to
$2.856 billion, and reported diluted earnings per share (EPS) grew 53 percent
to $.46.
For the full year, revenues grew 12 percent to $32.373 billion. Full-year
reported net income grew 17 percent to $9.126 billion, and reported diluted
EPS increased 20 percent to $1.46.
Fourth-quarter net income, excluding certain significant items, merger-
related costs, and the cumulative effect of a change in accounting principle,
increased by 40 percent to $2.943 billion. Diluted EPS, on the same basis,
increased by 45 percent to $.48. Full-year 2002 net income, on the same
basis, was up 19 percent to $9.913 billion. Diluted EPS, on the same basis,
rose by 21 percent to $1.59.
Pfizer management believes that investors' understanding of the performance
of the Company is enhanced by disclosing net income and diluted EPS excluding
costs related to merger activities; the impacts of the Cumulative Effect of a
Change in Accounting Principle; gains or losses on the sale of businesses,
product lines, and equity investments; co-promotion charges; and other items.
Pfizer lists these items in the attached financial schedule titled Income
Before Accounting Change Excluding Certain Significant Items and Merger-
Related Costs and reconciles this measure to net income determined according
to generally accepted accounting principles.
"By every measure, 2002 was another outstanding year for Pfizer," said Hank
McKinnell, chairman and chief executive officer. "Thanks to the hard work
and talent of the people of Pfizer, we achieved double-digit revenue growth,
and even stronger earnings growth, while continuing to fund the world's
largest private discovery and development efforts seeking new and better
prescription medicines.
"We met the needs of millions of patients around the world as we marketed
eight of the world's 30 largest-selling medicines, and four of the top 10.
On a stand-alone basis, we are exceptionally well positioned to maintain our
strong momentum in 2003 and beyond. The acquisition of Pharmacia will give
us an even stronger global platform for discovering, developing,
manufacturing, and marketing innovative medicines and consumer products."
Revenue growth was led by the Company's human pharmaceutical operations,
which achieved fourth-quarter revenues of $8.253 billion (up 15 percent) and
full-year revenues of $28.288 billion (up 12 percent).
Karen Katen, executive vice president of the Company and president of Pfizer
Pharmaceuticals Group, stated, "For the year, ten products that Pfizer
markets or co-promotes achieved sales of over $1 billion. Each of these
billion-dollar medicines -- Lipitor, Norvasc, Zoloft, Neurontin, Viagra,
Zithromax, Celebrex, Zyrtec, Diflucan, and Aricept -- are among the leaders
in their individual therapeutic categories. These products represented 85
percent of Pfizer's human pharmaceutical revenues and grew 15 percent in 2002
in the aggregate.
"The performance of our pharmaceutical business was also geographically
balanced. The U.S., Japan, Germany, the U.K., Spain, and Canada all
delivered double-digit revenue growth for the year. In each of these
markets, and in most markets around the world, new prescription growth for
our major products continued to outpace the growth of their individual
therapeutic categories. For example, in the U.S., new prescriptions for
Norvasc, the COX-2 franchise, and Zyrtec all grew at rates at least double
those of their respective categories.
"Our success is due in large part to our ability to establish strong,
differentiated competitive positions for our in-line and recently launched
products through ongoing clinical innovation and development programs, best-
in-class medical marketing support, and industry-leading sales efforts. The
performance of Lipitor, Zoloft, Geodon, Zithromax, Zyrtec, and Neurontin in
markets around the world was enhanced in 2002 by the addition of significant
new labeling, indications, or dosage forms."
Product performance, licensing, and regulatory highlights during the fourth
quarter include the following:
--- In November, Zyrtec achieved $1 billion in annual Pfizer revenues.
Zyrtec new prescriptions in the U.S. grew 23 percent in December over the
prior year, versus a 7 percent decline in the total market, according to
audited prescription data. After its recent FDA approval for enhanced
pediatric labeling, Zyrtec is now the only antihistamine approved in the U.S.
for use in infants as young as six months.
--- In December, Pfizer received approval from the FDA to market Relpax for
the acute treatment of migraine. Pfizer plans to launch Relpax in the U.S.
in the first quarter of 2003.
--- Lipitor, the world's leading cholesterol-lowering medicine and the
largest-selling pharmaceutical of any kind, achieved full-year sales of
$7.972 billion, an industry record. In November, Lipitor received FDA
approval for the treatment of familial hypercholesterolemia in children 10 to
17 years of age.
--- In November, Zoloft received an approvable letter from the FDA for
social anxiety disorder, with labeling for both acute and long-term
manifestations of this disorder. Among selective serotonin reuptake
inhibitors, Zoloft is approved in the U.S. for the most indications across
mood and anxiety disorders.
--- Pfizer and Neurocrine Biosciences, Inc., announced in December a global
agreement for the exclusive worldwide development and commercialization of
indiplon, Neurocrine's Phase III compound for the treatment of insomnia.
--- In December, Pfizer and Eyetech Pharmaceuticals, Inc., announced an
agreement to jointly develop and commercialize Eyetech's Macugen, a potential
treatment for the wet form of age-related macular degeneration and diabetic
macular edema, both leading causes of blindness.
--- In December, the results of the landmark Antihypertensive and Lipid
Lowering Therapy to Prevent Heart Attack Trial (ALLHAT) further demonstrated
Norvasc's efficacy and safety. Results were consistent across all patient
groups, including men, women, African-Americans, Hispanics, diabetics, and
patients over 65.
--- In the EVIDENCE clinical trial, published in the journal Neurology, the
multiple sclerosis (MS) therapy Rebif was shown to be more effective than
Avonex in reducing relapses and active brain lesions in patients with
relapsing remitting MS over 24 and 48 weeks of treatment. Pfizer co-promotes
Rebif with its discoverer, Serono, in the U.S.
--- Celebrex and Bextra, Pfizer and Pharmacia's COX-2-specific inhibitors,
accounted for 25 percent of audited monthly new prescriptions among U.S. non-
steroidal anti-inflammatory drugs in December. Study results presented at
the annual meeting of the American College of Rheumatology in October
confirmed Bextra's improved gastrointestinal and cardiovascular safety
profiles. Pharmacia and Yamanouchi jointly submitted a regulatory filing for
Celebrex in Japan in December 2002.
Pfizer is in the process of rolling out six new products in the U.S. and/or
the European Union: Vfend, Geodon, Bextra (discovered and developed by
Pharmacia), Spiriva (discovered and developed by Boehringer Ingelheim),
Relpax, and Rebif (discovered and developed by Serono).
The Company expects to complete regulatory filings in 2003 for
Lipitor/Norvasc dual therapy and for pregabalin in neuropathic pain,
epilepsy, and generalized anxiety disorder. Advanced-stage clinical studies
are continuing for several agents, including indiplon for insomnia; Macugen
for macular degeneration; capravirine for HIV/AIDS; lasofoxifene for
osteoporosis and other indications; CP-526,555 for smoking cessation; and
Exubera, an inhalable form of insulin under co-development, co-manufacture,
and co-marketing with Aventis, with the participation of Nektar Therapeutics
(formerly known as Inhale Therapeutic Systems).
Pfizer's flow of new human pharmaceutical products is supported by an R&D
pipeline that -- on a stand-alone basis -- currently contains 60 new product
enhancements plus 101 new molecular entities in development, for a total of
161 ongoing projects. The Pharmacia acquisition will augment that pipeline's
breadth and depth.
Animal Health sales in the fourth quarter increased 8 percent to $325
million, compared to the same period in 2001. This performance was led by
the strong growth of our companion-animal products Revolution, Clavamox, and
Synulox and of our livestock medicine RespiSure/Stellamune. Full-year Animal
Health sales increased 10 percent to $1.119 billion.
Sales of Pfizer's Consumer Healthcare (CHC) business grew 2 percent to $637
million in the fourth quarter. The rate of growth in the quarter was
negatively impacted by initial trade stocking of Listerine PocketPaks in the
prior year. Visine eye-care products and the Lubriderm skin-care lines both
delivered double-digit growth during the quarter. Full-year CHC sales
increased 7 percent to $2.530 billion.
David Shedlarz, executive vice president and chief financial officer of the
Company, said, "We sold, or are in the process of selling, several businesses
(Tetra, Adams, Schick-Wilkinson Sword, and certain women's health product
lines) that do not fit Pfizer's strategic goals. We expect to consummate
these remaining divestitures in the first half of 2003. Due to the partial-
year loss of contribution of these businesses to Pfizer's consolidated
results -- in part offset by interest income on the proceeds from their sale
-- we now forecast 2003 diluted EPS, excluding certain significant items and
merger-related costs, for Pfizer on a stand-alone basis of approximately
$1.80.
"Pfizer does not forecast reported 2003 diluted EPS in large part because the
exact timing of the Pharmacia acquisition and the exact terms of Pfizer's
divestitures have not yet been determined.
"We continue to expect the Pharmacia acquisition will provide substantial
benefits, including operational risk reduction and top- and bottom-line
growth opportunities," Mr. Shedlarz stated. "Approved by the shareholders of
both companies in early December, the acquisition is now awaiting clearance
by U.S. and European regulatory authorities, with closing expected during the
first quarter of 2003. We will provide an update of Pfizer's financial
projections including Pharmacia soon after the transaction closes,
incorporating Pharmacia's operating contribution, the level of cost
synergies, and other factors."
Dr. McKinnell concluded, "Pfizer enters 2003 with our business fundamentals
in excellent shape. As we look forward, we are optimistic about the
prospects for legislative progress that would provide modernized Medicare
benefits, including a prescription medicine benefit for older Americans.
Pfizer will continue to expand our efforts -- on a global basis -- to provide
our medicines to those in need through programs that include the Pfizer for
Living Share Card and global HIV/AIDS initiatives.
"With the integration of Pharmacia this year, Pfizer will continue to make
progress toward meeting our mission of becoming the world's most valued
company to patients, customers, colleagues, investors, business partners, and
the communities where we work and live."
For additional details, please see the attached financial schedules, product
revenue tables, and Supplemental Information.
DISCLOSURE NOTICE: The information contained in this document is as of
January 22, 2003. The Company assumes no obligation to update any forward-
looking statements contained in this document as a result of new information
or future events or developments.
This document and the attachments contain forward-looking information about
the Company's financial results and estimates, business prospects, and
products in research that involve substantial risks and uncertainties. You
can identify these statements by the fact that they use words such as
"anticipate," "estimate," "expect," "project," "intend," "plan," "believe,"
and other words and terms of similar meaning in connection with any
discussion of future operating or financial performance. Among the factors
that could cause actual results to differ materially are the following: the
success of research and development activities and the speed with which
regulatory authorizations, pricing approvals, and product launches may be
achieved; competitive developments affecting our current growth products; the
ability to successfully market both new and existing products domestically
and internationally; difficulties or delays in manufacturing; trade buying
patterns; ability to meet generic and branded competition after the loss of
patent protection for our products; trends toward managed care and health-
care cost containment; possible U.S. legislation affecting pharmaceutical
pricing and reimbursement, including Medicaid and Medicare; contingencies
related to actual or alleged environmental contamination; legal defense
costs, insurance expense, settlement costs, and the risk of an adverse
decision related to product liability, patent protection, and other lawsuits;
the Company's ability to protect its patents and other intellectual property
both domestically and internationally; interest rate and foreign currency
exchange rate fluctuations; governmental laws and regulations affecting
domestic and foreign operations, including tax obligations; changes in
generally accepted accounting principles; any changes in business, political,
and economic conditions due to the threat of future terrorist activity in the
U.S. and other parts of the world, and related U.S. military action overseas;
growth in costs and expenses; changes in our product mix; and the impact of
acquisitions, divestitures, restructurings, product withdrawals, and other
unusual items, including our ability to obtain the anticipated results and
synergies from our announced proposed acquisition of Pharmacia and the
increased uncertainty created by the integration of the two businesses, as
well as our sale of the Tetra business, our proposed sale of the Adams and
Schick-Wilkinson Sword businesses, and the timing and success of the sale of
the women's health product lines. A further list and description of these
risks, uncertainties, and other matters can be found in the Company's Annual
Report on Form 10-K for the fiscal year ended December 31, 2001, and in its
periodic reports on Forms 10-Q and 8-K (if any).
PFIZER INC AND SUBSIDIARY COMPANIES
CONDENSED CONSOLIDATED STATEMENT OF INCOME
(UNAUDITED)
(millions of dollars, except per share data)
Fourth Quarter % Incr./ Full Year % Incr./
2002 2001 (Decr.)* 2002 2001 (Decr.)*
Revenues $9,333 $8,180 14 $32,373 $29,024 12
Costs and expenses:
Cost of sales 1,178 1,136 4 4,045 3,823 6
Selling, informational
and administrative exps. 2,982 2,815 6 10,846 9,717 12
Research and development
expenses 1,511 1,490 1 5,176 4,776 8
Merger-related costs 243 242 1 630 819 (23)
Other (income)/
deductions--net (44) (50) (11) (120) (95) 27
Income from continuing
operations before
provision for taxes on
income, minority
interests and cumulative
effect of a change in
accounting principle 3,463 2,547 36 11,796 9,984 18
Provision for taxes on
income 751 611 23 2,609 2,433 7
Minority interests 5 2 119 6 14 (56)
Income from continuing
operations before
cumulative effect of a
change in accounting
principle 2,707 1,934 40 9,181 7,537 22
Discontinued operations:
Income from operations
of discontinued
businesses--net of tax 72 22 231 278 251 11
Gain on sale of
discontinued
business--net of tax 77 -- ** 77 -- **
Discontinued
operations--net of tax 149 22 584 355 251 41
Income before cumulative
effect of a change in
accounting principle 2,856 1,956 46 9,536 7,788 22
Cumulative effect of a
change in accounting
principle--net of tax -- -- -- (410) -- **
Net income $2,856 $1,956 46 $ 9,126 $ 7,788 17
Earnings per common
share--Basic:
Income from continuing
operations before
cumulative effect of a
change in accounting
principle $ .43 $ .32 34 $ 1.49 $ 1.21 23
Discontinued operations:
Income from operations
of discontinued
businesses--net of tax .02 -- ** .05 .04 25
Gain on sale of
discontinued
business--net of tax .01 -- ** .01 -- **
Discontinued
operations--net of tax .03 -- ** .06 .04 50
Income before cumulative
effect of a change in
accounting principle .46 .32 44 1.55 1.25 24
Cumulative effect of a
change in accounting
principle--net of tax -- -- -- (.07) -- **
Net income $ .46 $ .32 44 $ 1.48 $ 1.25 18
Earnings per common
share--Diluted:
Income from continuing
operations before
cumulative effect of a
change in accounting
principle $ .43 $ .30 43 $ 1.47 $ 1.18 25
Discontinued operations:
Income from operations
of discontinued
businesses--net of tax .02 -- ** .05 .04 25
Gain on sale of
discontinued
business--net of tax .01 -- ** .01 -- **
Discontinued
operations--net of tax .03 -- ** .06 .04 50
Income before cumulative
effect of a change in
accounting principle .46 .30 53 1.53 1.22 25
Cumulative effect of a
change in accounting
principle--net of tax -- -- -- (.07) -- **
Net income $ .46 $ .30 53 $ 1.46 $ 1.22 20
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* - Percentages may reflect rounding adjustments.
** - Calculation not meaningful.
1. The above financial statement presents the three-month and twelve-month
periods ended December 31 of each year. Subsidiaries operating outside the
United States are included for the three-month and twelve-month periods ended
November 30 of each year.
2. In December 2002, we sold the Tetra aquarium and pond supplies business
for $238.5 million. We recognized a gain on the sale of Tetra of $76.7
million (net of tax) in the fourth quarter and full year 2002. In December
2002, we also entered into an agreement to sell the Adams confectionery
business. In January 2003, we entered into an agreement to sell the Schick-
Wilkinson Sword shaving business. Additionally, we intend to sell the
FemHRT, Loestrin and Estrostep women's health product lines. We expect to
complete these divestitures in 2003. The above financial statement reflects
these businesses and product lines as discontinued operations for all periods
presented.
3. On January 1, 2002, we adopted the provisions of the Emerging Issues
Task Force (EITF) Issue No. 00-25, Vendor Income Statement Characterization
of Consideration Paid to a Reseller of the Vendor's Products - codified
within EITF Issue No. 01-09, Accounting for Consideration Given by a Vendor
to a Customer, which requires the cost of certain vendor consideration to be
classified as a reduction of revenue rather than as a marketing expense. As
a result, we restated the fourth quarter and full year 2001 financial
statement to reclassify certain marketing expenses from Selling,
informational and administrative expenses to Revenues. These
reclassifications have no effect on net income.
4. On January 1, 2002, we adopted Statement of Financial Accounting
Standards (SFAS) No. 142, Goodwill and Other Intangible Assets. As a result
of adopting SFAS No. 142, we recorded non-cash pre-tax charges of $565
million ($410 million net of tax) in the full year 2002 with $536 million for
the impairment provisions related to goodwill in our Animal Health business
and $29 million for the impairment provisions related to identifiable
intangible assets in our Consumer Products segment ($25 million) and
Pharmaceuticals segment ($4 million). These charges are recorded as a
cumulative effect of a change in accounting principle as of the beginning of
2002.
PFIZER INC AND SUBSIDIARY COMPANIES
INCOME BEFORE ACCOUNTING CHANGE
EXCLUDING CERTAIN SIGNIFICANT ITEMS AND MERGER-RELATED COSTS
(UNAUDITED)
(millions of dollars, except per share data)
Fourth Quarter % Incr./ Full Year % Incr./
2002 2001 (Decr.)* 2002 2001 (Decr.)*
Income before cumulative
effect of a change in
accounting principle,
as reported under
generally accepted
accounting principles $2,856 $1,956 46 $ 9,536 $ 7,788 22
Certain significant items
and merger-related costs 87 152 (43) 377 563 (33)
Income before cumulative
effect of a change in
accounting principle,
excluding certain
significant items and
merger-related costs $2,943 $2,108 40 $ 9,913 $ 8,351 19
Diluted earnings per
common share before
cumulative effect
of a change in
accounting principle,
as reported under
generally accepted
accounting principles $ .46 $ .30 53 $ 1.53 $ 1.22 25
Certain significant items
and merger-related costs .02 .03 (33) .06 .09 (33)
Diluted earnings per
common share before
cumulative effect
of a change in
accounting principle,
excluding certain
significant items and
merger-related costs $ .48 $ .33 45 $ 1.59 $ 1.31 21
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1. The above financial information presents the three-month and twelve-
month periods ended December 31 of each year. Subsidiaries operating outside
the United States are included for the three-month and twelve-month periods
ended November 30 of each year.
2. On January 1, 2002, we adopted Statement of Financial Accounting
Standards (SFAS) No. 142, Goodwill and Other Intangible Assets. As a result
of adopting SFAS No. 142, we recorded non-cash pre-tax charges of $565
million ($410 million net of tax) in the full year 2002 with $536 million for
the impairment provisions related to goodwill in our Animal Health business
and $29 million for the impairment provisions related to identifiable
intangible assets in our Consumer Products segment ($25 million) and
Pharmaceuticals segment ($4 million). These charges are recorded as a
cumulative effect of a change in accounting principle as of the beginning of
2002.
3. Income and diluted earnings per common share before cumulative effect of
a change in accounting principle as shown above exclude the following items:
(millions of dollars) Fourth Quarter Full Year
2002 2001 2002 2001
Significant items, pre-tax:
Gain on sale of discontinued business+ $(117) $ -- $(117) $ --
Warner-Lambert merger-related costs of
discontinued businesses+ 3 8 6 20
Harmonization of accounting methodology++ -- -- -- (175)
Gains on sales of product lines+++ (14) -- (34) --
Gains on sales of research-related
equity investments+++ -- -- -- (17)
Charges to write-down equity investments+++ 17 -- 45 --
Asset impairment charges+++ 18 -- 18 --
Co-promotion charges+++ -- -- 32 206
Various litigation matters* -- -- 25 --
Total significant items (93) 8 (25) 34
Merger-related costs, pre-tax:
Integration costs--Warner-Lambert 69 133 345 456
Pre-integration costs--Pharmacia 97 -- 98 --
Restructuring charges--Warner-Lambert 77 109 187 363
Total merger-related costs 243 242 630 819
Total significant items and merger-related
costs, pre-tax 150 250 605 853
Provision for taxes on income 63 98 228 290
Total significant items and merger-related
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costs, after-tax $ 87 $152 $ 377 $563
+ Included in Discontinued operations--net of tax.
++ Represents the harmonization of Pfizer/Warner-Lambert accounting
methodology for Medicaid and contract rebate accruals included in
Revenues.
+++ Included in Other (income)/deductions--net.
* $15 million included in Other (income)/deductions--net and $10
million in Selling, informational and administrative expenses.
PFIZER INC
SEGMENT/PRODUCT REVENUES
FOURTH QUARTER 2002
(UNAUDITED)
(millions of dollars)
QUARTER-TO-DATE
WORLDWIDE U.S. INTERNATIONAL
% % %
2002 2001 Chg 2002 2001 Chg 2002 2001 Chg
TOTAL
REVENUES 9,333 8,180 14 6,042 5,281 14 3,291 2,899 14
PHARMA-
CEUTICALS 8,696 7,557 15 5,626 4,855 16 3,070 2,702 14
TOTAL HUMAN
PHARMA-
CEUTICALS 8,253 7,152 15 5,451 4,696 16 2,802 2,456 14
-CARDIOVASCULAR
DISEASES 3,811 3,261 17 2,235 1,915 17 1,576 1,346 17
LIPITOR 2,317 1,883 23 1,536 1,275 20 781 608 28
NORVASC 1,066 962 11 507 459 11 559 503 11
CARDURA 136 149 (9) 6 14 (58) 130 135 (4)
ACCUPRIL/
ACCURETIC 191 166 15 124 108 15 67 58 14
-INFECTIOUS
DISEASES 1,166 1,114 5 799 752 6 367 362 1
ZITHROMAX 587 560 5 484 451 7 103 109 (5)
DIFLUCAN 318 292 9 183 165 11 135 127 6
VIRACEPT 85 87 (2) 85 87 (2) 0 0 --
-CENTRAL NERVOUS
SYSTEM
DISORDERS 1,670 1,320 27 1,345 1,066 26 325 254 27
ZOLOFT 775 646 20 636 526 21 139 120 17
NEURONTIN 676 498 36 575 427 35 101 71 44
GEODON 79 39 103 74 38 96 5 1 286
ARICEPT* 56 47 17 0 0 -- 56 47 17
-DIABETES 91 80 14 84 73 15 7 7 --
GLUCOTROL XL 87 74 17 81 70 17 6 4 26
-ARTHRITIS 103 93 10 1 1 (30) 102 92 11
CELEBREX** 31 21 48 0 0 -- 31 21 48
-ALLERGY 314 293 7 314 293 7 0 0 --
ZYRTEC 314 292 7 314 292 7 0 0 --
-VIAGRA 491 415 18 285 251 14 206 164 26
-ALLIANCE
REVENUE
(Aricept,
Bextra,
Celebrex,
Spiriva
and Rebif) 475 411 16 386 343 13 89 68 30
CAPSUGEL 118 104 14 44 41 8 74 63 17
ANIMAL HEALTH 325 301 8 131 118 11 194 183 6
CONSUMER
PRODUCTS 637 623 2 416 426 (2) 221 197 12
-CONSUMER
HEALTHCARE
PRODUCTS 637 623 2 416 426 (2) 221 197 12
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* - Represents direct sales under license agreement with Eisai Co., Ltd.
** - Represents direct sales under license agreement with Pharmacia
Corporation.
Certain amounts and percentages may reflect rounding adjustments.
Certain prior year data have been reclassified to conform to the current
year presentation.
PFIZER INC
SEGMENT/PRODUCT REVENUES
FULL YEAR 2002
(UNAUDITED)
(millions of dollars)
YEAR-TO-DATE
WORLDWIDE U.S. INTERNATIONAL
% % %
2002 2001 Chg 2002 2001 Chg 2002 2001 Chg
TOTAL
REVENUES 32,373 29,024 12 20,762 18,629 11 11,611 10,395 12
PHARMA-
CEUTICALS 29,843 26,670 12 18,982 16,974 12 10,861 9,696 12
TOTAL HUMAN
PHARMA-
CEUTICALS 28,288 25,240 12 18,301 16,349 12 9,987 8,891 12
HARMONIZATION
OF ACCOUNTING
METHODOLOGY+ 0 175 -- 0 175 -- 0 0 --
TOTAL HUMAN
PHARMA-
CEUTICALS
EXCLUDING
HARMONIZATION
OF ACCOUNTING
METHODOLOGY 28,288 25,065 13 18,301 16,174 13 9,987 8,891 12
-CARDIOVASCULAR
DISEASES 13,348 11,586 15 7,747 6,757 15 5,601 4,829 16
LIPITOR 7,972 6,448 24 5,336 4,423 21 2,636 2,025 30
NORVASC 3,846 3,581 7 1,776 1,667 7 2,070 1,914 8
CARDURA 531 551 (4) 21 50 (58) 510 501 2
ACCUPRIL/
ACCURETIC 668 604 11 430 375 15 238 229 4
-INFECTIOUS
DISEASES 3,615 3,638 (1) 2,262 2,283 (1) 1,353 1,355 --
ZITHROMAX 1,516 1,506 1 1,147 1,137 1 369 369 --
DIFLUCAN 1,112 1,066 4 610 576 6 502 490 3
VIRACEPT 336 364 (8) 336 364 (8) 0 0 --
-CENTRAL NERVOUS
SYSTEM
DISORDERS 5,726 4,740 21 4,599 3,839 20 1,127 901 25
ZOLOFT 2,742 2,365 16 2,245 1,929 16 497 436 14
NEURONTIN 2,269 1,751 30 1,935 1,510 28 334 241 39
GEODON 222 150 49 210 146 44 12 4 234
ARICEPT* 203 157 29 0 0 -- 203 157 29
-DIABETES 316 308 2 284 276 3 32 32 (2)
GLUCOTROL XL 297 283 5 277 266 4 20 17 17
-ARTHRITIS 363 365 (1) 3 6 (46) 360 359 --
CELEBREX** 100 76 31 0 0 -- 100 76 31
-ALLERGY 1,116 993 12 1,115 993 12 1 0 --
ZYRTEC 1,115 990 13 1,115 990 13 0 0 --
-VIAGRA 1,735 1,518 14 1,017 910 12 718 608 18
-ALLIANCE
REVENUE
(Aricept,
Bextra,
Celebrex,
Spiriva
and Rebif) 1,596 1,379 16 1,302 1,119 16 294 260 14
CAPSUGEL 436 409 6 177 177 -- 259 232 11
ANIMAL HEALTH 1,119 1,021 10 504 448 12 615 573 7
CONSUMER
PRODUCTS 2,530 2,354 7 1,780 1,655 8 750 699 7
-CONSUMER
HEALTHCARE
PRODUCTS 2,530 2,354 7 1,780 1,655 8 750 699 7
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+ - Represents the harmonization of Pfizer/Warner-Lambert accounting
methodology for Medicaid and contract rebate accruals.
* - Represents direct sales under license agreement with Eisai Co., Ltd.
** - Represents direct sales under license agreement with Pharmacia
Corporation.
Certain amounts and percentages may reflect rounding adjustments.
Certain prior year data have been reclassified to conform to the current
year presentation.
PFIZER INC
SUPPLEMENTAL INFORMATION
SHARES OUTSTANDING AND REPORTED EPS INFORMATION: FY02 FY01
Shares Outstanding (millions) - Basic EPS 6,155.5 6,239.1
Basic EPS $1.48 $1.25
Basic EPS Excluding the Cumulative Effect of a Change
in Accounting Principle, Certain Significant Items,
and Merger-Related Costs $1.61 $1.34
Shares Outstanding (millions) - Diluted EPS 6,241.4 6,361.4
Diluted EPS $1.46 $1.22
Diluted EPS Excluding the Cumulative Effect of a Change
in Accounting Principle, Certain Significant Items,
and Merger-Related Costs $1.59 $1.31
QUESTIONS:
Q1) What is the status of the Adams, Schick-Wilkinson Sword, Tetra, and
women's health businesses?
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A1)On December 17, 2002, we completed the sale of the Tetra aquarium and
pond-supplies business for $238.5 million to The Triton Fund, an independent
European private equity fund. Net income for the Tetra business, as well as
a gain on the sale of the business, net of tax, is reflected in discontinued
operations in the consolidated statement of income for the full year 2002.
In December 2002, Pfizer agreed to sell the Adams confectionery-products
business for $4.2 billion in cash to Cadbury Schweppes plc. In January 2003,
Pfizer agreed to sell the Schick-Wilkinson Sword shaving-products business
for $930 million to Energizer Holdings, Inc. Pfizer has decided to divest
three women's health product lines-FemHRT hormone replacement therapy and the
Loestrin and Estrostep contraceptive lines. 2002 and 2001 net income for the
Adams confectionery-products business, the Schick-Wilkinson Sword shaving-
products business, and the women's health product lines is reflected in
discontinued operations in the consolidated statement of income. The Adams,
Schick-Wilkinson Sword, and women's health divestitures are expected to close
in the first half of 2003. Full-year 2002 and 2001 revenues and net income
for these businesses are reflected below:
($ Millions) Revenues Net Income
2002 2001 2002 2001
Tetra Fish-Care $187 $181 $21 $15
Adams Confectionery 1,857 1,880 155 112
Schick-Wilkinson Sword Shaving 653 632 52 45
FemHRT/Loestrin/Estrostep 211 265 44 43
Other Previously Discontinued
Businesses -- -- 6 36
Operating Results from
Discontinued Businesses $2,908 $2,958 $278 $251
Gain on Sale of Discontinued
Business (Tetra Fish-Care) -- -- 77 --
Total Discontinued Operations $2,908 $2,958 $355 $251
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Q2) Describe the impact of the sale of businesses on 2003 expectations.
A2) Discontinued businesses generated income from operations-net of $278
million, or $.05 per diluted share, in 2002, excluding the gain on the
sale of Tetra. Due to the divestiture of Tetra and the expected loss
of a partial-year contribution of the Adams and Shaving Products
businesses and the women's health products in 2003 (in part offset by
interest income on the proceeds from their sale), Pfizer's 2003 EPS
forecast on a stand-alone basis, excluding certain significant items
and merger-related costs, has been reduced by $.04 to approximately
$1.80.
Future uses of the funds from the divestiture of these operations
include redeployment in Pfizer's core human pharmaceutical, consumer
healthcare, and animal health businesses and/or the purchase of Pfizer
common shares. Subsequent to the Pharmacia acquisition announcement,
Pfizer announced a $16 billion stock-purchase plan, which is expected
to be completed in 2003.
In addition, Pfizer's future rate of revenue growth and level of margin
expansion should benefit. In 2002, discontinued operations realized a
revenue decline of 2% and an operating margin (income before taxes
excluding other income/deductions-net, divided by revenues) of 15%.
Q3) What assumptions is Pfizer making about U.S. patent protection in its
earnings guidance as a stand-alone company for 2003?
A3) The earnings guidance for 2003 stated in A2 above assumes that Pfizer
will maintain U.S. marketing exclusivity for the full year for all of
its major currently patent-protected human pharmaceutical products,
except for Accupril, Minipress XL, and Cerebyx.
Q4) What significant advances were achieved by Pfizer's product portfolio
during the past quarter?
A4) Pfizer had several events in the quarter that will enhance sales of
existing products and strengthen the future product portfolio:
--- Food and Drug Administration (FDA) approval of Zyrtec to treat
year-round allergic rhinitis and chronic idiopathic urticaria in
infants as young as six months of age
---FDA approval of Relpax for the acute treatment of migraine
---FDA approval of Lipitor for the treatment of familial
hypercholesterolemia in children 10 to 17 years
---An FDA approvable letter for Zoloft's use in social anxiety disorder
---Agreement to jointly develop and commercialize indiplon for insomnia
with Neurocrine Biosciences
---Agreement to jointly develop and commercialize Macugen for the wet
form of macular degeneration and diabetic macular edema with Eyetech
Pharmaceuticals
---Reconfirmation in the ALLHAT trial of the efficacy and safety
profile of Norvasc
---Demonstration in the EVIDENCE trial that Rebif is more effective
than Avonex in reducing relapses and active brain lesions in patients
with relapsing remitting multiple sclerosis over 24 and 48 weeks of
treatment
---Reconfirmation of the gastrointestinal and cardiovascular safety of
Bextra in studies presented at the American College of Rheumatology
Q5) What factors contributed to Pfizer's strong performance in the fourth
quarter?
A5) In the quarter, the company achieved revenue growth of 14%, driven by
strong demand for both in-line and newly launched products across major
businesses and regions, as well as 1% favorable exchange effects.
Revenue growth for Pfizer's human pharmaceutical, animal health, and
consumer healthcare businesses was 15%, 8%, and 2%, respectively.
Double-digit revenue growth of 14% was achieved both in the U.S. and
international markets. Net income and diluted earnings per share,
excluding certain significant items, merger-related costs, and the
cumulative effect of a change in accounting principle, increased 40%
and 45%, respectively. In addition to the strong revenue performance,
income and diluted EPS growth reflected increases in selling,
informational and administrative expenses and research and development
expenses of 4% in aggregate, reflective, in part, of spending levels
for the same period in the prior year.
Q6) What factors contributed to the performance of Pfizer's pharmaceutical
business?
A6) Pfizer's human pharmaceutical sales grew 15% in the fourth quarter,
representing growth that was broad-based and balanced between U.S.
(+16%) and international (+14%) operations. Double-digit revenue
growth was achieved in the U.S., Japan, Germany, the U.K., Spain,
Canada, and other markets. An industry-record ten products that Pfizer
markets or co-promotes achieved more than $1 billion in 2002 sales.
These products (Lipitor, Norvasc, Zoloft, Neurontin, Viagra, Zithromax,
Celebrex, Zyrtec, Diflucan, and Aricept), representing 85% of Pfizer's
human pharmaceutical revenues, achieved growth in Pfizer revenue in
aggregate of 15% in 2002. For the twelve months ending September 2002,
the most recent period for which twelve-month audit data are available,
Pfizer's pharmaceutical sales exceeded market growth in nine of the ten
largest markets.
Q7) What is the status of the Pharmacia acquisition?
A7) We have largely completed transition planning for the acquisition,
which involved teams of hundreds of Pfizer and Pharmacia colleagues
across all business divisions and functions on a global basis. We have
made progress in continuing discussions with the European Commission's
Merger Task Force (MTF) and the U.S. Federal Trade Commission (FTC) on
the proposed merger between Pfizer and Pharmacia. The remaining open
matters with both the MTF and the FTC have been narrowed to a
relatively small number of issues. In December, both Pfizer and
Pharmacia shareholders overwhelmingly approved the acquisition. We
continue to expect that the acquisition will close in the first quarter
of this year. We will provide an update of Pfizer's financial
projections including Pharmacia soon after the transaction closes,
incorporating Pharmacia's operating contribution, the level of cost
synergies, and other factors.
Q8) What was the impact on Pfizer's continuing revenues from volume, price
changes, the effects of foreign exchange, and the 2001 accounting
harmonization?
A8) 4Q02 FY02
Volume 13.1% 11.9%
Price 0.0% 0.3%
Revenue Growth Excluding Accounting Harmonization
and Foreign Exchange 13.1% 12.2%
Foreign Exchange 1.0% 0.0%
Revenue Growth Excluding Accounting Harmonization 14.1% 12.2%
Accounting Harmonization 0.0% (0.7%)
Total Reported Revenue Growth 14.1% 11.5%
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Changes in foreign exchange rates had a positive effect on revenues in
the fourth quarter of $85 million, primarily due to the weakening of
the dollar relative to the euro and British pound, offset in part by
the devaluation of several Latin American currencies. Foreign exchange
had a nominal impact on revenues for the full year.
Q9) How have sales of Lipitor progressed?
A9) Worldwide sales of Lipitor increased to $2.317 billion in the fourth
quarter, growth of 23% compared to the same period in 2001. Lipitor is
the most widely prescribed statin for lowering cholesterol and the most
widely prescribed pharmaceutical product of any kind in the world.
Full-year sales totaled $7.972 billion, an industry record for annual
sales of a single pharmaceutical product. Lipitor has gained wide
physician and patient acceptance based on its ability to bring the vast
majority of patients to target cholesterol goals across the full dosing
range. The safety profile and efficacy of Lipitor have been
demonstrated in more than 400 ongoing and completed clinical trials
involving over 80,000 patients and in more than 36 million patient
years of therapy. In November, Lipitor received FDA approval for the
treatment of familial hypercholesterolemia in children 10 to 17 years
of age.
The initial results from the Anglo-Scandinavian Cardiac Outcomes Trial
(ASCOT) showed that Lipitor provided a significant benefit in reducing
fatal and non-fatal heart attacks as well as strokes. The study, which
involved nearly 20,000 patients with high blood pressure and at least
three other cardiovascular risk factors, was designed to compare the
effects of newer antihypertensive medicines with standard therapies in
reducing cardiac events. As a result of a significant benefit
demonstrated by Lipitor, the independent ASCOT steering committee
decided to stop the Lipitor portion of the study earlier than expected
to permit patients on placebo to have the option of statin therapy.
There is a significant opportunity for further growth, primarily
through expansion of the statin market. It is estimated that 54
million Americans are in need of medical therapy for high cholesterol,
but less than one-third of these people are actually receiving
treatment. Up to 150 million people worldwide with high cholesterol
are either not diagnosed or not meeting their cholesterol goals with
treatment.
Q10) What was the reason for the continued sales growth of Norvasc?
A10) Norvasc sales grew 11% in the fourth quarter of 2002 to $1.066
billion, compared to the same period in 2001. With full-year sales of
$3.846 billion in 2002, Norvasc was the fourth-largest-selling drug in
the world. Its success has been driven by its outstanding efficacy,
once-daily dosing, consistent 24-hour control of hypertension and
angina, and excellent safety and tolerability. Since its introduction
in 1990, Norvasc has become the world's most-prescribed branded
antihypertensive therapy. Norvasc has been studied in over 400,000
patients and has experienced 28 billion patient-days of therapy
worldwide.
In December 2002, the National Heart Lung and Blood Institute published
results of the landmark Antihypertensive and Lipid Lowering Therapy to
Prevent Heart Attack Trial (ALLHAT) in the Journal of the American
Medical Association. The results of ALLHAT, which involved over 42,400
high-risk hypertensive patients nationwide, support Norvasc as an
excellent choice to help patients reach their blood-pressure goal.
ALLHAT reconfirmed the efficacy and safety of Norvasc in a broad range
of patients as well as the importance of lowering elevated blood
pressure. Norvasc's results were consistent across all patient groups,
including men, women, African-Americans, Hispanics, diabetics, and
patients over 65. Norvasc demonstrated results comparable to the
diuretic chlorthalidone in the incidence of fatal coronary heart
disease, non-fatal heart attacks, strokes, and death. Most
hypertensive patients-60% in the study-require multiple medications to
reach their targeted blood-pressure goal, showing the importance to
doctors of having a range of medications available. Fewer Norvasc
patients in the study required multiple medicines to achieve their
goals. Norvasc also was shown to be well tolerated, and more Norvasc
patients remained on treatment than those assigned to chlorthalidone.
The study found no differences from chlorthalidone in several areas of
safety, including severe kidney disease, gastrointestinal bleeding, and
cancer.
Q11) What is the status of Lipitor/Norvasc dual therapy?
A11) We expect the Lipitor/Norvasc dual therapy for patients with both high
cholesterol and high blood pressure to be filed in 2003 and to be
available to patients in 2004.
Q12) How is Celebrex performing?
A12) Celebrex is the #1 branded non-steroidal anti-inflammatory drug
(NSAID) and the #1 COX-2-specific inhibitor in the world. Pfizer and
Pharmacia Corporation, the company that discovered and developed
Celebrex, co-promote this product in more than 60 countries. In the
countries where Pfizer and Pharmacia co-promote Celebrex, Pharmacia
records sales and Pfizer records a portion of revenue as alliance
revenue. In certain other countries, Pfizer directly records sales of
the product.
The product provides relief of a variety of painful conditions,
including the pain and inflammation of osteoarthritis (OA), adult
rheumatoid arthritis (RA), acute pain, and primary dysmenorrhea in
adults. In addition, Celebrex is approved to reduce the number of
adenomatous colorectal polyps in familial adenomatous polyposis-a rare
and devastating genetic disease that may result in colorectal cancer-as
an adjunct to usual care. Celebrex provides strong efficacy, excellent
tolerability, and a proven safety profile. Celebrex is now the COX-2-
specific inhibitor approved to treat the broadest range of conditions.
The Celebrex launch remains the most successful launch of any drug in
the history of the pharmaceutical industry. Celebrex is currently
receiving more than 2.1 million total prescriptions a month in the
U.S., which makes it the #1 prescribed arthritis brand in that market.
Through yearend 2002, about 26 million U.S. total prescriptions had
been written for Celebrex. Pharmacia and Yamanouchi jointly submitted
an NDA for Celebrex in Japan in December 2002.
Q13) How is Bextra performing?
A13) Bextra was launched in the U.S. in April 2002 for the relief of pain
and inflammation of OA, adult RA, and primary dysmenorrhea. Since the
launch of Bextra, U.S. physicians have dispensed more than 4.4 million
prescriptions to an estimated 2.2 million arthritis and dysmenorrhea
patients. In December 2002, Bextra achieved an 8% share of new
prescriptions of the NSAID market. Celebrex and Bextra together
achieved a share of 25%. Pfizer and Pharmacia, the company that
discovered and developed Bextra, co-promote this product in most major
world markets. In the countries where Pfizer and Pharmacia co-promote
Bextra, Pharmacia records sales and Pfizer records a portion of revenue
as alliance revenue. In certain other countries, Pfizer directly
records sales of the product.
Bextra offers once-daily dosing for OA and RA patients. The product
has a significantly lower incidence of endoscopically detected
gastroduodenal ulcers versus traditional NSAIDs (naproxen, ibuprofen,
and diclofenac) and significantly less dyspepsia versus naproxen. In
controlled comparative arthritis trials of up to 26 weeks, Bextra in
daily doses of 10 mg or 20 mg demonstrated an incidence of edema and
hypertension similar to comparator NSAIDs.
Following discussions with the FDA, the label was revised in November
to include a contraindication to the use of Bextra in patients who have
demonstrated allergic-type reactions to sulfonamides, statements in the
"warnings" section regarding serious skin and anaphylactoid reactions,
and information in the post-marketing experience section about
hypersensitivity and skin reactions captured as part of the drug safety
monitoring program for Bextra. The companies initiated this label
change based on rare spontaneous reports of serious skin and immune-
system reactions in patients taking Bextra since it was introduced to
the U.S. market. Some of these cases occurred in patients reported to
have previously experienced allergic-type reactions to drugs containing
sulfonamides. Celebrex, Vioxx, and most NSAIDs carry similar warnings
regarding hypersensitivity and potential skin reactions.
The Committee for Proprietary Medicinal Products in Europe has
reconfirmed the positive opinion it issued for Bextra in July 2002. We
expect to secure marketing authorization for Bextra in Europe during
2003.
Q14) How did Zoloft perform?
A14) Worldwide sales of Zoloft, a selective serotonin re-uptake inhibitor
(SSRI) for the treatment of depression and other mental disorders,
increased 20% to $775 million in the fourth quarter, compared to the
same period in 2001. Zoloft is the most-prescribed SSRI in the U.S.
The product has sustained strong growth globally notwithstanding the
launch of generic SSRIs, including fluoxetine in the U.S. and
paroxetine and citalopram elsewhere. Throughout 2002, Zoloft's growth
rate was comparable to the market in terms of usage in the U.S. and
other key markets.
Zoloft has proven efficacy, safety, and tolerability across a broad
range of depression and anxiety disorders and has the most approved
indications in the U.S. market across this range of disorders. This is
important from a clinical perspective, as there is significant co-
morbidity between depression and anxiety disorders: 50% of patients
with depression also have an anxiety disorder during a 12-month period.
Depression affects approximately 20 million Americans and significant
numbers of patients in other countries. Data recently presented at the
annual meetings of the European College of Neuropsychopharmacology
(ECNP) and the American College of Neuropsychopharmacology (ACNP)
continue to demonstrate Zoloft's utility across a wide range of
depressed patient types, including patients of diverse ages (the
elderly, children, and adolescents) and patients with medical illness
(including stroke and recent myocardial infarction). Data were
submitted to the FDA in December 2001 describing two trials in
pediatric depression (which qualified Zoloft for a six-month patent
extension).
Anxiety disorders for which Zoloft is approved include panic disorder,
obsessive-compulsive disorder (OCD) in adults and children, and post-
traumatic stress disorder (PTSD) in adults. These anxiety disorders
affect approximately 15 million Americans. In 2002, Zoloft received
labeling in the U.S. describing the results of long-term studies
demonstrating the usefulness of Zoloft in the maintenance treatment of
panic disorder and OCD. Zoloft is the only medicine approved for the
long-term treatment of PTSD, further highlighting Zoloft's strong
efficacy in the long term across a range of anxiety disorders. Long-
term treatment is important, as these disorders are chronic and
debilitating. Zoloft is also indicated for both the acute and long-
term treatment of OCD in children and adolescents.
In May 2002, Zoloft also received approval for the treatment of pre-
menstrual dysphoric disorder, with both continuous and luteal-phase
dosing regimens available. Filings for Zoloft's use in social anxiety
disorder are in preparation worldwide. Pfizer received an approvable
letter for an indication in social anxiety disorder from the FDA in
November and is expecting approval soon. Social anxiety is a chronic
anxiety disorder affecting approximately 10 million Americans. Recent
data were presented for the first time at both ECNP and ACNP on
Zoloft's efficacy, safety, and tolerability in the treatment of
generalized anxiety disorder.
Q15) How did Neurontin perform?
A15) Sales of Neurontin increased 36% to $676 million in the fourth
quarter, compared to the same period in 2001. Almost 10 million
patients have been prescribed Neurontin in the U.S. since its approval
in 1994. Neurontin is available in more than 100 countries.
Neurontin has also been approved in more than 60 markets for treatment
of a range of neuropathic pain conditions. Neurontin was approved by
the FDA in May 2002 for the management of post-herpetic neuralgia
(PHN). PHN is most commonly described as pain in the area affected by
herpes zoster persisting at least three months after healing of the
skin rash. Herpes zoster is a painful viral infection also known as
shingles. In the U.S. alone, more than one million new cases of herpes
zoster are diagnosed each year. Approximately 10-15% of all patients
with herpes zoster develop PHN, which, once established, can persist
for many years. Neurontin is the first oral medication approved in the
U.S. for this condition.
Q16) How did Zithromax perform?
A16) Zithromax sales increased 5% to $587 million in the fourth quarter
compared to the same period in 2001. Zithromax continues to be the
number one branded antibiotic in both oral-solid and liquid-suspension
formulations in the U.S. Its U.S. market-share growth increased 1.5
and 1.8 percentage points for the oral-solid and liquid-suspension
formulations, respectively, during the past year. It is the second-
largest-selling antibiotic worldwide. The product is recognized by
physicians for its broad efficacy, compliance advantages, favorable
side-effect profile, and a good-tasting liquid formulation for
children. In September 2002, Pfizer launched the new Zithromax Tri-Pak
dosage form, the first and only three-day regimen for the treatment of
acute bacterial exacerbations of chronic obstructive pulmonary disease
(COPD), with Zithromax given at a dose of 500 mg once daily. COPD is
responsible for 500,000 hospitalizations in the U.S. per year.
Intravenous formulations of Zithromax were approved in Italy and Spain
during the fourth quarter.
Q17) What factors account for Viagra's performance?
A17) Viagra is the world's most recognized pharmaceutical brand. Worldwide
sales of Viagra for erectile dysfunction (ED) grew 18% to $491 million
in the fourth quarter, compared to the same period in 2001. The
product is among the most widely prescribed medications, with over 120
million prescriptions having been written since launch by nearly
600,000 physicians for more than 20 million men worldwide, including 12
million men in the U.S. About half of American men aged 40 to 70 are
affected with ED to some degree.
Viagra allows many men with ED to achieve erections, leading to an
improvement in their sexual health. New data highlight Viagra's fast
onset of action and continue to confirm efficacy and safety after
almost five years on the market.
--- New data from a recently completed study designed to assess
Viagra's onset of action showed that Viagra works in as little as 14
minutes in some patients and in about a half hour in most.
--- New data recently appearing in an article in the Journal of the
American Medical Association showed that Viagra was effective in
treating men with antidepressant-associated sexual dysfunction. These
improvements in sexual health can lead to better compliance with
antidepressant therapy.
--- The largest post-marketing study to date involving more than
22,000 patients by an independent academic research unit confirmed
Viagra's efficacy and safety profile.
Q18) How did Diflucan perform?
A18) Diflucan remains the leading systemic antifungal in the world. Sales
of Diflucan increased 9% to $318 million in the fourth quarter,
compared to the same period in 2001. This sales growth, after 14 years
on the market, reflects the unique features and benefits of Diflucan
and the medical need that it continues to fulfill. It treats systemic
fungal infections, often present in critically ill hospitalized
patients, as well as fungal infections of the mouth (thrush), throat,
and esophagus. Diflucan is also effective as a single-dose oral
treatment for vaginal candidiasis.
The Diflucan Partnership was developed to offer Diflucan at no charge to
HIV/AIDS patients in the 50 least-developed countries where HIV/AIDS is
most prevalent, as identified by the United Nations. Patient numbers
and clinical sites continue to increase, with more than 2 million doses
dispensed and more than 27,000 prescriptions processed. The program
has now been launched in about a dozen countries. In the 50 least-
developed countries with an HIV prevalence of greater than one percent,
roughly 12 million people are reported to be infected with HIV/AIDS.
Although Diflucan is not a treatment for HIV/AIDS, it has proven highly
effective in treating two opportunistic infections, cryptococcal
meningitis and esophageal candidiasis, that afflict large numbers of
people with AIDS. Cryptococcal meningitis is a life-threatening brain
infection caused by the yeast Cryptococcus neoformans. Of those
suffering from untreated meningitis, the mortality rate is more than
90%.
Q19) What factors are driving Zyrtec's growth?
A19) Sales of Zyrtec, a leading prescription antihistamine in the U.S.,
grew 7% to $314 million in the fourth quarter, compared to the same
period in 2001. In November, seven years after launch, Zyrtec achieved
$1 billion in annual sales in the U.S. Zyrtec provides twice the
symptom relief versus Claritin as demonstrated in two two-day pollen
chamber studies. Among established prescription antihistamines, Zyrtec
continues to be the fastest-growing in new prescriptions in the U.S.
This growth can be attributed to strong performances by Zyrtec syrup
and Zyrtec-D 12 Hour. Zyrtec-D 12 Hour is the only prescription oral
antihistamine/decongestant combination medicine approved to treat both
year-round indoor and outdoor allergies as well as nasal congestion.
With 30% of all allergy sufferers also experiencing nasal congestion,
and with decongestant combinations accounting for about one fifth of
total U.S. antihistamine prescriptions, a significant opportunity
exists for Zyrtec-D. It is the number one antihistamine prescribed by
doctors for chronic idiopathic urticaria (hives).
In November 2002, Zyrtec received FDA approval to treat year-round
allergic rhinitis and chronic idiopathic urticaria in infants as young
as six months of age. That expands on the existing Zyrtec pediatric
indication for seasonal and perennial allergic rhinitis and urticaria
for children aged two to 11 years. Zyrtec is now the first and only
antihistamine-Rx or OTC-approved for use in infants as young as six
months old. Zyrtec is already the number one antihistamine product
prescribed by pediatricians.
Q20) How is Aricept performing?
A20) Aricept continues to lead the Alzheimer's disease (AD) market with a
70% worldwide market share, more than $1 billion of annual sales, and
more than 1 billion cumulative patient days of therapy prescribed. Its
market leadership has been built on a large body of clinical evidence
supporting its excellent efficacy and tolerability.
About 10% of people over 65 suffer from AD, including 4 million
Americans. AD results in estimated direct costs of $29 billion a year
and total costs of as much as $100 billion. Most of these costs are
related to nursing-home care. The Delay to Nursing Home Placement
study, expected to be published later this year, showed that AD
patients who were treated with Aricept had a 21-month delay in nursing-
home placement compared to patients who received no or limited Aricept.
A study of patients from a large Medicare managed-care organization
published in Managed Care Interface found that annual healthcare costs
of community-based patients with AD treated with Aricept for more than
nine months averaged about $4,200 less in direct costs than patients
not receiving treatment.
Currently, approximately 1.3 million patients suffer from vascular
dementia (VaD), cognitive decline following a stroke. VaD is second
only to AD as the most common form of dementia in most parts of the
world. In September 2002, Pfizer's co-marketing partner Eisai filed a
supplemental New Drug Application for the use of Aricept in the
treatment of VaD. This submission is based on the results of two large
pivotal studies designed to evaluate the efficacy and safety of Aricept
in more than 1,200 VaD patients.
Q21) How is Geodon performing?
A21) Sales of Geodon (marketed as Zeldox in some markets) totaled $79
million in the fourth quarter of 2002, up 103% compared to the same
period in 2001. Geodon has been prescribed for over 250,000 patients
worldwide. It has been launched in Sweden, Germany, the U.S., and 21
other markets. In the U.S., Geodon has become widely accepted on the
formularies of all state Medicaid programs, the Veterans
Administration, and more than 1,200 hospitals. In Germany, where
Geodon was launched in May 2002, it has established its position as the
most successfully launched atypical antipsychotic.
In clinical trials, Geodon was shown to be as effective as Risperdal
and Zyprexa in controlling both positive and negative symptoms, with a
lower incidence of extra-pyramidal side effects than Risperdal and
significantly less weight gain and other metabolic indices (lipid
levels, glucose control) than Zyprexa. Movement disorders and
significant weight gain are distressing and stigmatizing to patients
and often result in non-compliance. Patients who gain weight may also
be at greater risk for cardiovascular complications such as increased
lipid levels and poor glycemic control. Studies where patients have
been switched to Geodon from other atypicals show significant
improvement after the switch. Other analyses in institutional settings
show significant cost savings for institutions after the switch from
Zyprexa to Geodon.
The intramuscular (IM) formulation of Geodon was launched in September
in the U.S., where it is the first atypical antipsychotic medicine with
an IM formulation and approved for treating acute agitation in
schizophrenia. Acute agitation is one of the most common psychiatric
emergencies and is characterized by uncooperative or even violent
behavior. IM medicines are important in this setting because of their
rapid onset of action. Geodon for Injection has demonstrated superior
efficacy and low incidences of movement disorders compared to Haldol
IM, currently the most widely used IM antipsychotic. Geodon also
allows for continuity of care, as patients with acute agitation are
rapidly controlled with the IM formulation and then make a smooth
transition to oral Geodon.
Pfizer is also studying Geodon in mania. The Company submitted a
filing to the FDA in October 2002 for an oral-suspension dosage form.
Q22) What is the status of Relpax?
A22) Relpax, an oral 5-HT 1b/1d agonist for the acute treatment of
migraine, had sales of $6 million in the fourth quarter and $16 million
for the full year of 2002. To date, Relpax has been launched in 24
countries, including most of Europe and Japan. In December 2002,
Relpax was approved by the FDA. Pfizer plans to launch the product in
the U.S. in the first quarter of 2003.
Relpax has been shown to be effective across an extensive clinical-
trials program involving more than 9,000 patients and more than 70,000
migraine attacks. A publication in the October issue of Neurology
demonstrates Relpax's excellent relief of migraine pain and associated
symptoms (nausea, sensitivity to light and sound) and rapid improvement
in patient functioning. While an estimated 28 million Americans-one in
five women and one in 15 men-experience migraines, this disorder
remains substantially underdiagnosed and undertreated. Most migraine
sufferers are between the ages of 30 and 50, the most productive years
of life. Migraines cost American employers about $13 billion annually
because of missed workdays and lost productivity.
Q23) What is the current status of Pfizer's new antifungal Vfend?
A23) Worldwide sales of the new antifungal Vfend were $29 million in the
quarter and $42 million for the full year of 2002. Vfend was launched
in both oral and intravenous forms in August 2002 in the U.S. and in
September 2002 in Europe. In the U.S., Vfend is indicated for primary
treatment of acute invasive aspergillosis and salvage therapy for rare
but serious fungal infections caused by the pathogens Scedosporium
apiospermum and Fusarium spp. In Europe, Vfend is also approved for
the treatment of fluconazole-resistant serious invasive Candida
infections (including C. krusei). In the largest prospective
comparative clinical trial ever conducted in invasive aspergillosis, a
deadly fungal infection occurring in immunocompromised patients, 53% of
patients who started therapy with Vfend had a successful response at 12
weeks, compared to 32% of those who started therapy with amphotericin
B. Additionally, Vfend offered patients a 22% relative survival
benefit versus amphotericin B. The number of hospitalized patients at
risk for serious fungal infections is growing as more patients undergo
bone marrow/stem cell and solid organ transplants, as well as
aggressive chemotherapy for cancer. Fungal infections in these immuno-
compromised patients are associated with high morbidity and mortality
and require prompt and effective treatment.
Vfend can be administered both orally and intravenously, unlike most
currently available treatments, which are available in intravenous form
only. This allows patients to step down in therapy from intravenous to
oral administration and potentially allows the patient to be discharged
from the hospital sooner.
Q24) What is the status of Spiriva?
A24) Spiriva, discovered and developed by Boehringer Ingelheim (BI) and co-
promoted by Pfizer and BI, is the first once-a-day inhaled
bronchodilator treatment for chronic obstructive pulmonary disease
(COPD) and a significant advance over other treatment options. Spiriva
was approved by regulatory authorities in Europe in April 2002 and in
Canada in November 2002. The product has now been launched in 13
countries, including Germany, Canada, and the U.K., and is very well
received in the market. The global roll-out will continue in 2003,
with 18 launches planned. In September 2002, an advisory committee to
the FDA recommended that Spiriva be approved for the long-term, once-
daily maintenance treatment of bronchospasm associated with COPD.
COPD is a chronic respiratory disorder that includes chronic bronchitis
and emphysema and is characterized by limited airflow accompanied by
symptoms such as dyspnea (shortness of breath), cough, wheezing, and
increased sputum production. In the U.S. alone, there are
approximately 17 million sufferers of COPD, although up to 50% remain
undiagnosed. Patients often suffer symptoms for many years before
being diagnosed and getting appropriate treatment. It is estimated
that one in five smokers will develop COPD, which is the fifth-leading
cause of death worldwide and the fourth-leading cause of death in the
U.S. Data from clinical trials involving more than 3,000 patients
worldwide have demonstrated that Spiriva is highly effective in
providing sustained bronchodilation and is well tolerated, with dry
mouth as the main side effect. In December 2002, a large clinical
trial (UPLIFT-Understanding the Potential for Long-term Impacts with
Tiotropium) was initiated to better characterize the long-term health
benefits of Spiriva. UPLIFT will enroll up to 6,000 patients from 37
countries.
Q25) What is the status of Pfizer's co-promotion of Rebif with Serono?
A25) In July 2002, Pfizer and Serono announced an agreement to co-promote
Serono's multiple sclerosis (MS) treatment Rebif in the U.S., and
Pfizer sales representatives began promoting Rebif in October 2002. MS
is a chronic inflammatory condition of the nervous system and is the
most common non-traumatic neurological disease in young adults. MS
affects approximately 350,000 Americans. While symptoms can vary, the
most common include blurred vision, numbness or tingling in the limbs,
and problems with strength and coordination. The relapsing forms of
the disease are the most common forms of MS. Rebif has been shown to
decrease the frequency of clinical exacerbations and delay the
accumulation of physical disability associated with relapsing forms of
MS.
Data from the EVIDENCE study, published in a recent edition of the
journal Neurology, showed that Rebif was more effective than Avonex in
reducing relapses and active brain lesions in patients with relapsing
remitting MS over 24 and 48 weeks of therapy. The study, which
involved 677 patients with relapsing remitting MS, showed that 75% of
patients who received Rebif did not have a relapse after 24 weeks of
treatment compared to 63% of patients treated with Avonex. The
improvement was sustained at 48 weeks, at which point 62% of Rebif
patients were relapse-free, as compared to 52% of Avonex patients.
Q26) What is the status of the Pfizer for Living Share Card program?
A26) On January 15, 2002, we launched an innovative prescription benefit
program called the Pfizer for Living Share Card. The program is
designed to help a targeted group of patients access tools to manage
their health. The program includes three elements: a membership card
that enables patients to receive up to a 30-day supply of only a Pfizer
medicine for $15, a help line to assist low-income senior citizens in
learning about other healthcare services and benefits, and easy-to-read
health information on 16 common medical conditions.
The Pfizer Share Card is available to Medicare enrollees with annual
gross incomes of less than $18,000 ($24,000 for couples) who lack
prescription-drug coverage or who are not eligible for Medicaid or any
other publicly funded prescription benefit programs. The projected
financial impact of this program is included in Pfizer's current
revenue and earnings growth guidance.
The response to the Share Card has been overwhelmingly positive. The
Pfizer Share Card can be used at more than 50,000 retail pharmacies
nationwide, representing 97% of all U.S. pharmacies. Since the
program's announcement, the Share Card call center has:
--- Received more than 1.5 million inquiries
--- Received more than 825,000 requests for applications
--- Reviewed more than 339,000 completed applications
--- Enrolled more than 269,000 members, and
--- Filled more than 1 million Pfizer prescriptions
Q27) How did the Animal Health business perform?
A27) In the fourth quarter, Animal Health sales increased 8% to $325
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million, compared to the same period in 2001. Our companion-animal
products Revolution, Clavamox, and Synulox and our livestock medicine
RespiSure/Stellamune showed strong growth. Full-year revenues
increased 10% to $1.119 billion.
Q28) How did Pfizer's Consumer Healthcare business perform?
A28) Sales of Consumer Healthcare (CHC) products grew 2% to $637 million in
the fourth quarter of 2002, compared to the same period in 2001. The
rate of growth was negatively impacted by initial trade stocking of
Listerine PocketPaks in 2001. Visine eye-care products and the
Lubriderm skin-care lines both delivered double-digit growth during the
quarter. Full-year CHC sales increased 7% to $2.530 billion.
Q29) What caused the 4% increase in cost of sales in the quarter?
A29) Cost of sales increased 4% in the quarter, compared to a 14% increase
in net sales, mainly due to favorable business, geographic, and product
mix, as well as manufacturing cost improvements.
Q30) How was 2002 impacted by costs associated with the mergers of Warner-
Lambert and Pharmacia? What are the results and outlook for expense
synergies relating to both transactions?
A30) Pfizer incurred $630 million in restructuring and other merger-related
costs in continuing operations in 2002. Pre-integration costs
associated with the Pharmacia acquisition accounted for $98 million of
this total. Integration, restructuring, and transaction costs of $2.8
billion (excluding costs associated with the termination of the failed
Warner-Lambert/American Home Products merger) have been recorded from
the close of the Warner-Lambert transaction to date. Costs associated
with the Warner-Lambert transition are essentially complete and the
total is consistent with previous estimates.
Synergies associated with the Warner-Lambert acquisition totaled $1.8
billion in 2002-$200 million more than the original projection of $1.6
billion. Pfizer's estimate of forecasted cost savings associated with
the Pharmacia acquisition will be provided shortly after the close of
the transaction.
Q31) What were the principal factors affecting other (income)/deductions-
net?
A31) ($ millions) Fourth Quarter Full Year
(Income)/Deductions 2002 2001 2002 2001
Net Interest Income ($37) ($61) ($131) ($273)
Co-Promotion Charges -- -- 32 206
Gains on the Sales of Research-
Related Equity Investments -- -- -- (17)
Write-Down of Equity Investments 17 -- 45 --
Asset Impairment Charges 18 -- 18 --
Amortization of Goodwill and Other
Intangibles 4 29 28 94
Gains on the Sales of Product Lines (14) -- (34) --
Various Litigation Matters -- -- 15 --
Other (32) (18) (93) (105)
Other (Income)/Deductions-Net ($44) ($50) ($120) ($95)
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The reduction in interest income is primarily a factor of significantly
lower short-term interest rates in 2002 versus 2001, partially offset
by larger invested balances. Amortization of goodwill and intangibles
is lower in 2002 versus 2001 as a result of the adoption of SFAS No.
142-Goodwill and Other Intangible Assets (see Q&A 33).
Q32) What is the status of Pfizer's share-purchase program?
A32) In June 2002, the company announced a new authorization to purchase up
to $10 billion of the company's common stock. This program was
increased to $16 billion after the Pharmacia acquisition announcement
and is expected to be completed during 2003. During the fourth quarter
of 2002, approximately 8.6 million shares were purchased under the new
authorization, at a total cost of about $270 million. To date,
approximately 102 million shares have been purchased under this
authorization, at a total cost of about $3 billion.
Q33) How did changes to accounting regulations impact Pfizer's 2002
results?
A33) On January 1, 2002, we adopted the provisions of Statement of
Financial Accounting Standards (SFAS) No. 142, Goodwill and Other
Intangible Assets. Under the provisions of SFAS No. 142, intangible
assets with indefinite lives and goodwill are no longer amortized but
are subject to annual impairment tests. Separable intangible assets
with finite lives continue to be amortized over their useful lives. In
the second quarter of 2002, we determined and recorded, retroactive to
the beginning of 2002 in accordance with accounting principles
generally accepted in the United States of America, a non-cash pretax
charge of $536 million for the impairment provisions as they relate to
goodwill in the Animal Health business. In the first quarter of 2002,
we recorded a non-cash charge of $29 million for the impairment
provisions as they relate to identifiable intangible assets in the
consumer products ($25 million) and pharmaceutical ($4 million)
segments. The aggregate amount of these charges for 2002, $565 million
($410 million after tax), is reported as a one-time cumulative effect
of a change in accounting principle.
Q34) What is the status of Pfizer's pension plans?
A34) Pfizer maintains pension plans in the U.S. and abroad in accordance
with local laws and regulations. In 2002, we made voluntary
contributions in excess of $600 million to our pension plans in major
markets. In the U.S., we have established defined-benefit pension
plans in accordance with ERISA and have traditionally contributed the
maximum allowed by the IRS-an amount significantly above government-
mandated minimum funding requirements. At this time, our ERISA plans
do not require additional funding, and assets are sufficient to meet
current benefit obligations. Our assumption for the expected long-term
rate of return on assets in our U.S. plans is 9% for 2003. The
discount rate used in calculating the Company's U.S. pension expense
for 2003 is 6.9%.
Q35) When is Pfizer's conference call?
A35) Pfizer will be holding a conference call for analysts and investors to
discuss fourth-quarter earnings at 1:00 PM today. To ensure universal
access, the conference call will be simultaneously broadcast over
Pfizer's corporate website (www.pfizer.com) and will be archived for
five days thereafter.