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The following is an excerpt from a S-1 SEC Filing, filed by BRUKER DALTONICS INC on 4/14/2000.
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BRUKER CORP - S-1 - 20000414 - FUTURE_SALE

SHARES ELIGIBLE FOR FUTURE SALE

Upon completion of this offering, Bruker Daltonics will have outstanding shares of our common stock. Of these shares, the shares offered hereby ( shares if the underwriters' over-allotment option is exercised in full) will be freely tradable without restriction or further registration under the Securities Act, unless purchased by "affiliates" of Bruker Daltonics as that term is defined in Rule 144 described below. The remaining 45,500,000 shares of common stock outstanding upon closing of the offering are "restricted securities" as that term is defined in Rule 144.

In general, under Rule 144, as amended, a person who has beneficially owned shares for at least one year is entitled to sell in "brokers' transactions" or to market makers, within any three-month period commencing 90 days after the date of this prospectus, a number of shares that does not exceed the greater of (a) one percent of the number of shares of common stock then outstanding, approximately shares immediately after the completion of this offering ( shares if the underwriters' over-allotment option is exercised in full), or (b) generally, the average weekly trading volume in our common stock during the four calendar weeks preceding the required filing of a Form 144 with respect to such sale. Sales under Rule 144 are generally subject to the availability of current public information about Bruker Daltonics. Under Rule 701, persons who purchase shares upon exercise of options granted prior to the effective date of this offering are entitled to sell such shares 90 days after the effective date of this offering in reliance on Rule 144, without having to comply with the holding period requirements of Rule 144.

Each of our stockholders has agreed to certain restrictions on their ability to sell, offer, contract or grant any option to sell, pledge, transfer or otherwise dispose of shares of our common stock for a period of 180 days after the date of this prospectus, without the prior written consent of Deutsche Bank Securities Inc. All 45,000,000 of our outstanding shares, not including the offered hereby, are subject to 180-day lockup agreements. These shares are eligible for sale 180 days after the commencement of this offering, subject to the requirements of Rule 144.

Prior to this offering, there has not been any public market for our common stock. Future sales of substantial amounts of our common stock in the public market could adversely affect the prevailing market prices and impair our ability to raise capital through the sale of equity securities.

57

UNDERWRITING

Subject to the terms and conditions of the underwriting agreement, the underwriters named below, through their representatives, Deutsche Bank Securities Inc., Warburg Dillon Read LLC and Thomas Weisel Partners LLC, have severally agreed to purchase from Bruker Daltonics the following respective number of shares of common stock at a public offering price less the underwriting discounts and commissions set forth on the cover page of this prospectus:

Underwriter                                                  Number of Shares
-----------                                                  ----------------
Deutsche Bank Securities Inc...............................
Warburg Dillon Read LLC....................................
Thomas Weisel Partners LLC.................................
      Total................................................

The underwriting agreement provides that the obligations of the several underwriters to purchase the shares of common stock offered hereby are subject to various conditions precedent and that the underwriters will purchase all shares of the common stock offered hereby, other than those covered by the over-allotment option described below, if any of these shares are purchased. In addition, the underwriting agreement provides that, in the event of a default by an underwriter, in certain circumstances the purchase commitments of non-defaulting underwriters may be increased or the underwriting agreement may be terminated.

The underwriters propose to offer the shares of common stock to the public at the public offering price set forth on the cover of this prospectus and to dealers at a price that represents a concession not in excess of $ per share under the public offering price. The underwriters may allow, and these dealers may re-allow, a concession of not more than $ per share to other dealers. After the initial public offering, representatives of the underwriters may change the offering price and other selling terms.

We have granted to the underwriters an option, exercisable not later than 30 days after the date of this prospectus, to purchase up to additional shares of common stock at the public offering price less the underwriting discounts and commissions set forth on the cover page of this prospectus. The underwriters may exercise this option only to cover over-allotments made in connection with the sale of the common stock offered hereby. To the extent that the underwriters exercise this option, each of the underwriters will become obligated, subject to conditions, to purchase approximately the same percentage of additional shares of common stock as the number of shares of common stock to be purchased by it in the above table bears to the total number of shares of common stock offered hereby. We will be obligated, pursuant to the option, to sell these additional shares of common stock to the underwriters to the extent the option is exercised. If any additional shares of common stock are purchased, the underwriters will offer the additional shares on the same terms as those on which the other shares are being offered.

The underwriting fee is equal to the public offering price per share of common stock less the amount paid by the underwriters to us per share of common stock. The underwriting

58

fee is currently expected to be % of the initial public offering price. We have agreed to pay the underwriters the following fees, assuming either no exercise or full exercise by the underwriters of the underwriters' over-allotment option:

                                                                          Total Fees
                                                         ---------------------------------------------
                                                          Without Exercise of    With Full Exercise of
                                         Fee Per Share   Over-Allotment Option   Over-Allotment Option
                                         -------------   ---------------------   ---------------------
Fees paid by Bruker Daltonics..........     $                   $                      $

In addition, we estimate that our share of the total expenses of this offering, excluding underwriting discounts and commissions, will be approximately $ .

We have agreed to indemnify the underwriters against some specified types of liabilities, including liabilities under the Securities Act, and to contribute to payments the underwriters may be required to make in respect of any of these liabilities.

Each of our officers and directors and all of our stockholders have agreed not to offer, sell, contract to sell, or otherwise dispose of, or enter into any transaction that is designed to, or could be expected to, result in the disposition of any shares of our common stock or other securities convertible into or exchangeable or exercisable for shares of our common stock or derivatives of our common stock owned by these persons prior to this offering or common stock issuable upon exercise of options or warrants held by these persons for a period of 180 days after the effective date of the registration statement of which this prospectus is a part without the prior written consent of Deutsche Bank Securities Inc. This consent may be given at any time without public notice. We have entered into a similar agreement with the representatives of the underwriters. There are no agreements between the representatives and any of our stockholders or affiliates releasing them from these lock-up agreements prior to the expiration of the 180-day period.

The representatives of the underwriters have advised us that the underwriters do not intend to confirm sales to any account over which they exercise discretionary authority.

In order to facilitate the offering of our common stock, the underwriters may engage in transactions that stabilize, maintain, or otherwise affect the market price of our common stock. Specifically, the underwriters may over-allot shares of our common stock in connection with this offering, thus creating a short position in our common stock for their own account. A short position results when an underwriter sells more shares of common stock than that underwriter is committed to purchase. Additionally, to cover these over-allotments or to stabilize the market price of our common stock, the underwriters may bid for, and purchase, shares of our common stock in the open market. Finally, the representatives, on behalf of the underwriters, may also reclaim selling concessions allowed to an underwriter or dealer if the underwriting syndicate repurchases shares distributed by that underwriter or dealer. Any of these activities may maintain the market price of our common stock at a level above that which might otherwise prevail in the open market. These transactions may be effected on the Nasdaq National Market or otherwise. The underwriters are not required to engage in these activities and, if commenced, may end any of these activities at any time.

At our request, the underwriters have reserved for sale, at the initial public offering price, up to shares, or %, of our common stock being sold in this offering for our vendors, employees, family members of employees, customers and other third parties. These purchasers are expected to agree not to offer, sell, contract to sell, or otherwise dispose of, or enter into any transaction that is designed to, or could be expected to, result in the disposition of any shares of our common stock or other securities convertible into or exchangeable or exercisable for shares of our common stock or derivatives of our common

59

stock acquired by these persons in this offering or common stock issuable upon exercise of options or warrants held by these persons for a period of 180 days after the effective date of the registration statement of which this prospectus is a part without the prior written consent of Deutsche Bank Securities Inc. The number of shares of our common stock available for sale to the general public will be reduced to the extent these reserved shares are purchased. Any reserved shares that are not purchased by these persons will be offered by the underwriters to the general public on the same basis as the other shares in this offering.

Pricing of This Offering

Prior to this offering, there has been no public market for the common stock. Consequently, the initial public offering price for our common stock has been determined by negotiation among us and the representatives of the underwriters. Among the principal factors considered in determining the initial public offering price were:

- prevailing market conditions;

- our results of operations in recent periods;

- the market capitalization and stage of development of other companies that we and the representatives of the underwriters believe to be comparable to our business; and

- estimates of our business potential.

The estimated initial public offering price range set forth on the cover of this preliminary prospectus is subject to change as a result of market conditions and other factors.

Thomas Weisel Partners LLC, one of the representatives of the underwriters, was organized and registered as a broker-dealer in December 1998. Since December 1998, Thomas Weisel Partners has been named as a lead or co-manager on 153 filed public offerings of equity securities, of which 109 have been completed, and has acted as a syndicate member in an additional 80 public offerings of equity securities. Thomas Weisel Partners does not have any material relationship with us or any of our officers, directors or other controlling persons, except with respect to its contractual relationship with us pursuant to the underwriting agreement entered into in connection with this offering.

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CERTAIN UNITED STATES TAX CONSIDERATIONS FOR NON-UNITED STATES HOLDERS

There are federal income and estate tax consequences related to the ownership and disposition of our common stock by a non-U.S. holder. A non-U.S. holder is any person or entity that, for United States federal income tax purposes, is either a non-resident individual, or other corporation organized or created under non-U.S. law corporation, an estate that is not on its worldwide income or a trust that is either not subject to primary supervision over its administration by a United States court or not subject to the control of a U.S. person with respect to substantial trust decisions. Partnerships organized outside of the United States and their partners should consult their own tax advisors about the consequences of holding our common stock, as the tax treatment with respect to foreign partnerships and their partners is complex.

Individuals may, in certain cases, be deemed to be resident aliens, as opposed to non-resident aliens, by virtue of being present in the United States for at least 31 days in the calendar year and for an aggregate of at least 183 days during a three-year period ending in the current calendar year (counting for such purposes, all of the days present in the current year, one-third of the days present in the immediately preceding year, and one-sixth of the days present in the second preceding year). Resident aliens are generally subject to United States federal income tax as if they were United States citizens.

This summary does not discuss all United States federal income tax considerations that may be relevant to non-U.S. holders in light of their particular circumstances or to non-U.S. holders that may be subject to special treatment under United States federal income tax laws. This summary assumes that non-U.S. holders hold their stock as capital assets. Furthermore, this summary does not discuss aspects of United States federal income taxation that may be applicable to holders of options to purchase our common stock, nor does it address any aspects of non-U.S. taxation or United States state or local taxation.

This summary is based on current provisions of the Internal Revenue Code of 1986, as amended (the "Code"), existing, temporary and proposed regulations promulgated thereunder, and administrative and judicial interpretations thereof, all of which are subject to change, possibly with retroactive effect.

THIS SUMMARY IS OF A GENERAL NATURE ONLY AND IS NOT INTENDED TO BE, AND SHOULD NOT BE CONSTRUED TO BE, LEGAL, BUSINESS OR TAX ADVICE TO ANY PARTICULAR SHAREHOLDER. SHAREHOLDERS SHOULD CONSULT THEIR TAX ADVISORS WITH RESPECT TO THE UNITED STATES FEDERAL, STATE, LOCAL AND NON-U.S. TAX CONSEQUENCES OF THE DESCRIBED TRANSACTIONS IN THEIR PARTICULAR CIRCUMSTANCES.

Dividends

In the event that dividends are paid on shares of our common stock, dividends paid to a non-U.S. holder of our common stock generally will be subject to United States withholding tax at a 30% rate, unless an applicable income tax treaty provides for a lower withholding rate.

Currently, the applicable United States Treasury regulations presume, absent actual knowledge to the contrary, that dividends paid to an address in a foreign country are paid to a resident of such country for purposes of the 30% withholding tax. However, recently finalized United States Treasury regulations provide that in the case of dividends paid after December 31, 2000, United States backup withholding tax at a 31% rate will be imposed on dividends paid to non-U.S. holders if the certification or documentary evidence procedures

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and requirements set forth in such regulations are not satisfied directly or through an intermediary. Further, in order to claim the benefit of an applicable income tax treaty rate for dividends paid after December 31, 2000, a non-U.S. holder must comply with certification requirements set forth in the recently finalized United States Treasury regulations.

The 30% withholding tax does not apply to dividends paid to a non-U.S. holder that provides a Form 4224 or, after December 31, 2000, a Form W-8ECI, certifying that the dividends are effectively connected with the non-U.S. holder's conduct of a trade or business within the United States. Instead, the effectively connected dividends will generally be subject to regular United States income tax as if the non-U.S. holder were a United States resident. If the non-U.S. holder is eligible for the benefits of a tax treaty between the United States and the holder's country of residence, any effectively connected income will be subject to United States federal income tax only if it is attributable to a permanent establishment in the United States mainlined by the holder. A non-U.S. corporation receiving effectively connected dividends may also be subject to an additional "branch profits tax" imposed at a rate of 30% (or a lower treaty rate) on an earnings amount that is net of the regular tax.

A non-U.S. holder may obtain a refund of any excess amounts withheld by filing an appropriate claim for refund along with the required information with the Internal Revenue Service ("IRS").

Gain on Disposition of Common Stock

A non-U.S. holder generally will not be subject to United States federal income or withholding tax requirements in respect of gain recognized on a disposition of common stock unless:

(a) the gain is effectively connected with the conduct of a trade or business of the non-U.S. holder within the United States or of a partnership, trust or estate in which the non-U.S. holder is a partner or beneficiary within the United States and, if certain tax treaties apply, is attributable to a permanent establishment of the non-U.S. holder, within the United States;

(b) the non-U.S. holder is an individual who holds our common stock as a capital asset within the meaning of Section 1221 of the Internal Revenue Code, is present in the United States for 183 or more days in the taxable year of the disposition and meets certain other tax law requirements;

(c) the non-U.S. holder is a United States expatriate required to pay tax pursuant to the provisions of United States tax law; or

(d) we are or have been a "United States real property holding corporation" for federal income tax purposes at any time during the shorter of the five-year period preceding such disposition or the period that the non-U.S. holder holds our common stock.

We believe that we are not, have not been and do not anticipate becoming, a United States real property holding corporation for United States federal income tax purposes.

A non-U.S. holder who is an individual and is described in clause (a) or
(c) above will be required to pay tax on the net gain derived from a sale of our common stock at regular graduated United States federal income tax rates. Further, a non-U.S. holder who is an individual and who is described in clause (b) above generally will be subject to a flat 30% tax on the gain derived from a sale. A non-U.S. holder that is a corporation and that is described

62

in clause (a) above generally will be required to pay tax on its net gain at regular graduated United States federal income tax rates. Such non-U.S. holder may also have to pay a branch profits tax.

Federal Estate Tax

For United States federal estate tax purposes, an individual's gross estate will include our common stock owned, or treated as owned, by an individual. Generally, this will be the case regardless whether or not such individual was a United States citizen or a United States resident. This general rule of inclusion may be limited by an applicable estate tax or other treaty.

Information Reporting and Backup Withholding Tax

Under United States Treasury regulations, we must report annually to the Internal Revenue Service and to each non-U.S. holder the amount of dividends paid to such holder and the tax withheld with respect to such dividends. These information reporting requirements apply whether withholding is required. Copies of the information returns reporting such dividends and withholding may also be made available to the tax authorities in the country in which the non-U.S. holder is a resident under the provisions of an applicable income tax treaty or agreement.

Dividends

Currently, the 31% United States backup withholding tax generally will not apply:

(a) to dividends which are paid to non-U.S. holders and are taxed at the regular 30% withholding tax rate as discussed above; or

(b) before January 1, 2001, to dividends paid to a non-U.S. holder at an address outside of the United States unless the payor has actual knowledge that the payee is a U.S. holder.

The recently finalized United States Treasury regulations provide that in the case of dividends paid after December 31, 2000, a non-U.S. holder generally will be subject to backup withholding tax at the rate of 31% unless:

(a) specified certification procedures are followed; or

(b) specified documentary evidence procedures are followed.

Sale or Exchange of Common Stock

U.S. information reporting and backup withholding generally will not apply to a payment of proceeds of a disposition of common stock where the transaction is effected outside the United States through a non-U.S. office of a non-U.S. broker. However, information reporting requirements, but not backup withholding, generally will apply to such a payment if the broker is:

- a U.S. person;

- a foreign person that derives 50% or more of its gross income for certain periods from the conduct of a trade or business in the U.S.;

- a controlled foreign corporation as defined in the Code; or

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- a foreign partnership with certain U.S. connections (for payments made after December 31, 2000).

Information reporting requirements will not apply in the above cases if the broker has documentary evidence in its records that the holder is a non-U.S. holder and certain conditions are met or the holder otherwise establishes an exemption.

A non-U.S. holder will be required to certify its non-U.S. status, in order to avoid information reporting and backup withholding at a 31% rate on disposition proceeds, where the transaction is effected by or through a U.S. office of a broker.

The tax liability of persons subject to backup withholding will be reduced by the amount of tax withheld. When withholding results in an overpayment of taxes, a refund may be obtained if the required information is furnished to the IRS.

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LEGAL MATTERS

The validity of the shares of common stock offered hereby will be passed upon for Bruker Daltonics by Hutchins, Wheeler & Dittmar, A Professional Corporation, Boston, Massachusetts. Richard M. Stein, a stockholder of Hutchins, Wheeler & Dittmar, holds options to purchase 3,000 shares of the common stock of Bruker Daltonics and will purchase shares of common stock in this offering. Mr. Stein is also a Director and the Secretary of Bruker Daltonics. Certain legal matters in connection with the offering will be passed upon for the underwriters by Ropes & Gray, Boston, Massachusetts.

EXPERTS

BDO, independent auditors, have audited our combined financial statements as of and for the year ended December 31, 1997, as set forth in their report. Ernst & Young LLP, independent auditors, have audited our consolidated and combined financial statements as of and for the years ended December 31, 1998 and 1999, as set forth in their report. We have included our financial statements in this prospectus and elsewhere in this registration statement in reliance on BDO and Ernst & Young LLP's reports, given upon their authority as experts in accounting and auditing.

WHERE YOU CAN FIND MORE INFORMATION

We have filed a registration statement on Form S-1 with the Securities and Exchange Commission, or SEC, for our common stock that we are offering by this prospectus. This prospectus does not contain all of the information set forth in the registration statement and the exhibits and schedules thereto. For further information with respect to us and our common stock, we make reference to the registration statement and to the exhibits and schedules filed therewith. Statements contained in this prospectus as to the contents of any contract or any other document referred to are not necessarily complete, and in each instance, reference is made to the copy of such contract or other document filed as an exhibit to the registration statement, each such statement being qualified in all respects by such reference. A copy of the registration statement may be inspected by anyone without charge at the SEC's principal office in Washington, D.C., and copies of all or any part of the registration statement may be obtained from the Public Reference Section of the SEC, 450 Fifth Street, N.W., Washington, D.C. 20549, upon payment of certain fees prescribed by the SEC. Please call the SEC at 1-800-SEC-0330 for further information on the operation of the public reference rooms. The SEC maintains a web site that contains reports, proxy and information statements and other information regarding registrants that file electronically with the SEC. The address of the web site is http://www.sec.gov. Upon completion of the offering, we will be subject to the information reporting requirements of the Securities Exchange Act of 1934, as amended and, in accordance therewith, will file reports, proxy statements and other information with the SEC.

We intend to furnish our stockholders with annual reports containing financial statements audited by our independent public accountants and quarterly reports for the first three fiscal quarters of each fiscal year containing unaudited interim financial information.

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BRUKER DALTONICS INC.

INDEX TO FINANCIAL STATEMENTS

Report of Ernst & Young LLP, Independent Auditors for the
  years ended
  December 31, 1998 and 1999................................     F-2

Consolidated Balance Sheets as of December 31, 1998 and
  1999......................................................     F-3

Combined / Consolidated Statements of Operations for the
  years ended
  December 31, 1998 and 1999................................     F-4

Combined / Consolidated Statements of Stockholders' Equity
  for the years ended
  December 31, 1998 and 1999................................     F-5

Combined / Consolidated Statements of Cash Flows for the
  years ended
  December 31, 1998 and 1999................................     F-6

Notes to Financial Statements for the years ended December
  31, 1998
  and 1999..................................................     F-7

Report of BDO, Independent Auditors for the year ended
  December 31, 1997.........................................    F-20

Report of Ernst & Young LLP, Independent Auditors for the
  year ended December 31, 1997..............................    F-21

Combined Balance Sheet as of December 31, 1997..............    F-22

Combined Statement of Operations for the year ended December
  31, 1997..................................................    F-23

Combined Statement of Stockholders' Equity for the year
  ended December 31, 1997...................................    F-24

Combined Statement of Cash Flows for the year ended December
  31, 1997..................................................    F-25

Notes to Financial Statements for the year ended December
  31, 1997..................................................    F-26

All financial data schedules for which provision is made in the applicable accounting regulation of the Securities and Exchange Commission are not required under the related instructions or are inapplicable and therefore have been omitted.

F-1

Report of Ernst & Young LLP, Independent Auditors

The Board of Directors
Bruker Daltonics Inc.

We have audited the accompanying consolidated balance sheets of Bruker Daltonics Inc. (the Company), as of December 31, 1998 and 1999, the related combined statements of operations, stockholders' equity, and cash flows for the year ended December 31, 1998, and the related consolidated statements of operations, stockholders' equity, and cash flows for the year ended December 31, 1999. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with auditing standards generally accepted in the United States. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of Bruker Daltonics Inc. at December 31, 1998 and 1999, and the results of its operations and its cash flows for each of the years then ended, in conformity with accounting principles generally accepted in the United States.

                                          /s/ ERNST & YOUNG LLP

Boston, Massachusetts
March 11, 2000

F-2

BRUKER DALTONICS INC.

CONSOLIDATED BALANCE SHEETS

                                                                     December 31,
                                                              ---------------------------
                                                                  1998           1999
                                                              ------------   ------------
                                         ASSETS

Current assets:
  Cash and cash equivalents.................................  $ 1,134,916    $ 2,443,142
  Accounts receivable, less allowances for doubtful accounts
   of $157,198 in 1998 and $113,861 in 1999.................    9,743,922     12,203,888
  Inventories...............................................   17,033,673     25,441,844
  Deferred income taxes.....................................      369,150        899,000
  Other assets..............................................    1,055,375        532,446
                                                              -----------    -----------
      Total current assets..................................   29,337,036     41,520,320
                                                              -----------    -----------

Restricted cash.............................................    5,895,871             --
Property, plant and equipment, net..........................   28,365,580     25,350,543
Intangible and other assets.................................      242,827        438,197
                                                              -----------    -----------
          Total assets......................................  $63,841,314    $67,309,060
                                                              ===========    ===========

                          LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
  Short-term bank borrowings................................  $ 2,941,239    $ 2,496,350
  Accounts payable..........................................    3,254,786      6,661,399
  Due to affiliated companies...............................      147,239      1,496,240
  Accrued expenses..........................................    1,720,043      3,805,486
  Accrued payroll...........................................    1,656,727      1,741,669
  Customer deposits.........................................    9,872,513      8,323,465
  Warranty reserves.........................................    3,206,621      4,739,013
  Income taxes payable......................................      199,982        176,690
                                                              -----------    -----------
      Total current liabilities.............................   22,999,150     29,440,312
                                                              -----------    -----------

Deferred revenue............................................       99,841        393,371
Long-term debt..............................................   14,982,498     12,843,582
Deferred income tax liabilities.............................    8,667,382      8,785,712
Contingent liabilities......................................    6,752,312      5,788,434

Stockholders' equity:
  Common stock, $0.01 par value, authorized 100,000,000
   shares, issued and outstanding 45,500,000 shares in 1998
   and 1999.................................................      455,000        455,000
  Additional paid-in capital................................    6,045,000      6,045,000
  Accumulated other comprehensive loss......................   (1,322,828)    (2,854,829)
  Retained earnings.........................................    5,162,959      6,412,478
                                                              -----------    -----------
      Total stockholders' equity............................   10,340,131     10,057,649
                                                              -----------    -----------
          Total liabilities and stockholders' equity........  $63,841,314    $67,309,060
                                                              ===========    ===========

The accompanying notes are an integral part of these statements.

F-3

BRUKER DALTONICS INC.

COMBINED / CONSOLIDATED STATEMENTS OF OPERATIONS

                                                                Year Ended December 31,
                                                              ---------------------------
                                                                  1998           1999
                                                              ------------   ------------
                                                                COMBINED     CONSOLIDATED
Product revenue.............................................  $40,157,261    $60,620,349
Other revenue...............................................    2,049,740      4,070,101
                                                              -----------    -----------
          Net revenue.......................................   42,207,001     64,690,450
                                                              -----------    -----------

Costs and operating expenses:
  Cost of product revenue...................................   19,672,357     31,617,724
  Sales and marketing.......................................    7,434,968     11,345,265
  General and administrative................................    2,212,594      3,411,138
  Research and development..................................   13,048,670     15,138,114
  Patent litigation costs...................................           --        537,817
                                                              -----------    -----------
          Total costs and operating expenses................   42,368,589     62,050,058
                                                              -----------    -----------

Operating income (loss) from continuing operations..........     (161,588)     2,640,392

Other income................................................      173,737        130,219
Interest expense, net.......................................     (900,829)      (907,682)
                                                              -----------    -----------
Income (loss) from continuing operations before provision
  for income taxes..........................................     (888,680)     1,862,929
Provision for income taxes..................................           --        986,887
                                                              -----------    -----------
Income (loss) from continuing operations....................     (888,680)       876,042
Income from discontinued operations, net of income taxes....      383,414        373,477
                                                              -----------    -----------
Net income (loss)...........................................  $  (505,266)   $ 1,249,519
                                                              ===========    ===========

Net income (loss) per share-basic and diluted
  Income (loss) from continuing operations..................  $     (0.02)   $      0.02
  Income from discontinued operations, net of income
    taxes...................................................         0.01           0.01
                                                              -----------    -----------
Net income (loss) per share.................................  $     (0.01)   $      0.03
                                                              ===========    ===========
Shares used in computing net income (loss) per share-basic
  and diluted...............................................   45,500,000     45,500,000
                                                              ===========    ===========

The accompanying notes are an integral part of these statements.

F-4

BRUKER DALTONICS INC.

COMBINED / CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY

                              Common Stock
                         -----------------------                                Accumulated
                          Bruker       Bruker      Additional                      Other           Total
                         Daltonics    Daltonik       Paid-in      Retained     Comprehensive   Stockholders'
                           Inc.         GmbH         Capital      Earnings     Income (Loss)      Equity
                         ---------   -----------   -----------   -----------   -------------   -------------
Balance as of December
  31, 1997.............  $ 52,500    $3,489,184    $  697,500    $7,600,096     $(1,969,494)    $ 9,869,786
  Issuance of common
   stock...............   402,500            --     5,347,500            --              --       5,750,000
  Payments to
   stockholders in
   connection with
   reorganization of
   business............        --    (3,489,184)           --    (1,931,871)             --      (5,421,055)
  Foreign currency
   translation
   adjustment..........        --            --            --            --         646,666         646,666
  Net loss.............        --            --            --      (505,266)             --        (505,266)
                                                                                                -----------
  Net comprehensive
   income..............        --            --            --            --              --         141,400
                         --------    ----------    ----------    ----------     -----------     -----------
Balance as of December
  31, 1998.............   455,000            --     6,045,000     5,162,959      (1,322,828)     10,340,131
  Foreign currency
   translation
   adjustment..........        --            --            --            --      (1,532,001)     (1,532,001)
  Net income...........        --            --            --     1,249,519              --       1,249,519
                                                                                                -----------
  Net comprehensive
   loss................        --            --            --            --              --        (282,482)
                         --------    ----------    ----------    ----------     -----------     -----------
Balance as of December
  31, 1999.............  $455,000    $       --    $6,045,000    $6,412,478     $(2,854,829)    $10,057,649
                         ========    ==========    ==========    ==========     ===========     ===========

The accompanying notes are an integral part of these statements.

F-5

BRUKER DALTONICS INC.

COMBINED / CONSOLIDATED STATEMENTS OF CASH FLOWS

                                                               Year Ended December 31,
                                                              --------------------------
                                                                 1998           1999
                                                              -----------   ------------
                                                               COMBINED     CONSOLIDATED
Operating activities:
Income (loss) from continuing operations....................  $  (888,680)  $    876,042
Adjustments to reconcile income (loss) from continuing
  operations to net cash provided by (used in) continuing
  operations:
    Depreciation and amortization...........................    2,604,582      3,486,625
    Deferred income taxes...................................      526,061        875,095
    Charge for purchase of in-process research and
      development...........................................           --        100,000
    Changes in operating assets and liabilities:
      Accounts receivable...................................   (6,272,587)    (3,605,416)
      Inventories...........................................   (1,802,029)   (10,264,776)
      Other assets..........................................     (862,924)        91,990
      Accounts payable and accrued expenses.................     (479,955)     6,374,182
      Warranty reserve......................................    1,758,596      2,033,985
      Contingent liabilities................................     (367,257)            --
      Income taxes payable..................................     (525,681)          (469)
      Deferred revenue......................................     (281,799)       294,710
      Customer deposits.....................................       66,098      4,680,139
                                                              -----------   ------------
Net cash provided by (used in) continuing operations........   (6,525,575)     4,942,107
Net cash provided by (used in) discontinued operations......       (9,068)       495,126
                                                              -----------   ------------
    Net cash provided by (used in) operating activities.....   (6,534,643)     5,437,233

Investing activities:
Purchases of property and equipment.........................   (2,887,675)    (4,235,677)
Acquisition of business.....................................           --       (200,000)
                                                              -----------   ------------
    Net cash used in investing activities...................   (2,887,675)    (4,435,677)

Financing activities:
Proceeds from long-term debt................................   14,212,750             --
Proceeds from short-term borrowings.........................    2,603,898      1,000,000
Payments on short-term borrowings...........................      (50,000)    (1,086,700)
Advances from (payments to) affiliated companies............   (8,616,816)       444,370
Issuance of common stock....................................    5,750,000             --
Payments to stockholders....................................   (5,435,012)            --
                                                              -----------   ------------
    Net cash provided by financing activities...............    8,464,820        357,670

Effect of exchange rate changes.............................       70,979        (51,000)
                                                              -----------   ------------
Net change in cash and cash equivalents.....................     (886,519)     1,308,226
Cash and cash equivalents at beginning of year..............    2,021,435      1,134,916
                                                              -----------   ------------
Cash and cash equivalents at end of year....................  $ 1,134,916   $  2,443,142
                                                              ===========   ============
Supplemental cash flow information:
  Cash paid for interest....................................  $ 1,018,765   $  1,231,867
  Cash paid for taxes.......................................      152,821        463,987

The accompanying notes are an integral part of these statements.

F-6

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS

1. Description of Business

Bruker Daltonics Inc. and its wholly-owned subsidiaries (the "Company") design, manufacture and market proprietary life science systems based on its mass spectrometry core technology platforms. The Company also sells a broad range of field analytical systems for substance detection and pathogen identification. The Company maintains major technical centers in Europe, North America and Japan. Bruker Daltonics allocates substantial capital and resources to research and development and is party to various collaborations and strategic alliances. The Company's diverse customer base includes pharmaceutical companies, biotechnology companies, academic institutions and government agencies.

These financial statements represent the consolidated accounts of Bruker Daltonics Inc., and its wholly-owned subsidiaries as of December 31, 1998 and 1999 and for the year ended December 31, 1999, and the combined accounts of Bruker Daltonics Inc., and its affiliated companies for the year ended December 31, 1998 (see Note 3). All significant intercompany accounts and transactions have been eliminated in consolidation and combination, respectively.

2. Summary of Significant Accounting Policies

USE OF ESTIMATES

The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.

CASH AND CASH EQUIVALENTS

The Company considers all highly liquid investments with original maturities of 90 days or less at date of purchase to be cash equivalents. Cash and cash equivalents are carried at cost, which approximates fair market value at year end.

RESTRICTED CASH

At December 31, 1998, $5,895,871 of cash was restricted as part of an advance deposit for a product distribution agreement between Bruker Daltonik GmbH and Hewlett-Packard Company (HP). The original advance was $6,680,002, from which the Company withdrew amounts for payment as products were delivered and accepted by HP. This deposit was reduced to $1,200,000 in the second quarter of 1999 and is no longer restricted. The Company has included the entire balance of $5,895,871 in customer deposits as of December 31, 1998.

CONCENTRATION OF CREDIT RISK

Financial instruments which subject the Company to credit risk consist of cash and cash equivalents and accounts receivables. The risk with respect to cash and cash equivalents is minimized by the Company's policy of investing in short-term financial instruments issued by highly-rated financial institutions. The risk with respect to accounts receivable is minimized by

F-7

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

2. Summary of Significant Accounting Policies (Continued) the credit worthiness of the Company's customers. The Company performs periodic credit evaluations of its customers' financial condition and generally does not require collateral. Credit losses have been within management's expectations. For the years ended December 31, 1998 and 1999, two customers accounted for an aggregate of 32% and 30%, respectively, of the Company's product revenue. Accounts receivables for these two customers accounted for an aggregate of 40% and 3% of total receivables as of December 31, 1998 and 1999, respectively.

INVENTORIES

Inventories are stated at the lower of cost or market with cost determined by the first-in, first-out, ("FIFO") method.

Inventories include demonstration equipment which the Company offers to current and potential customers. The Company amortizes its demonstration equipment over a three year period. Amortization expense for demonstration equipment was $258,844 and $306,792 for the years ended December 31, 1998 and 1999, respectively.

PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment are stated at cost and are being depreciated on a straight-line basis over the estimated useful lives of the assets as follows:

Buildings............................  25 years
Machinery and equipment..............  5--10 years
Furniture and fixtures...............  3--5 years
Leasehold improvements...............  Shorter of 15 years or the life of
                                       the lease

SOFTWARE COSTS

Purchased software is capitalized at cost and is amortized over the estimated useful life, generally three years. Software developed for use in the Company's products is expensed as incurred and is classified as research and development expense.

OTHER ASSETS

Other assets consist principally of patents and licenses. Patents, patent applications and rights are stated at acquisition cost. Amortization of patents is recorded using the straight-line method over the legal lives of the patents, generally for periods ranging up to ten years. Accumulated amortization of these assets amounted to $983,702 and $1,120,840, as of December 31, 1998 and 1999, respectively.

LONG-LIVED ASSETS

The Company reviews long-lived assets for impairment, in accordance with Statement of Financial Accounting Standard (SFAS) No. 121, "Accounting for the Impairment of Long-Lived Assets to Be Disposed Of," whenever events or circumstances indicate that the

F-8

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

2. Summary of Significant Accounting Policies (Continued) carrying amount of an asset may not be recoverable. Assets are written-down to fair value when the carrying costs exceed this amount. Any impairment losses are determined based upon estimated future cash flows and fair values. To date, no such indicators of impairment have been identified.

WARRANTY COSTS

The Company provides a one year parts and labor warranty with the purchase of equipment. The anticipated cost for this one year warranty is accrued upon recognition of the sale and is included as a current liability on the accompanying balance sheets.

CUSTOMER DEPOSITS

Under the terms and conditions of contracts with certain customers, the Company requires an advance deposit. These deposit amounts are recorded as a liability until revenue is recognized against the specific contract at time of acceptance of the system.

EARNINGS PER SHARE

Basic earnings per share is calculated by dividing net earnings by the weighted-average number of common shares outstanding during the period. The diluted earnings per share computation includes the effect of shares which would be issuable upon the exercise of outstanding stock options, reduced by the number of shares which are assumed to be purchased by the Company from the resulting proceeds at the average market price during the period. At December 31, 1998 and 1999 there were no stock options outstanding, therefore basic and diluted earnings per share are equivalent.

FAIR VALUE OF FINANCIAL INSTRUMENTS

The Company's financial instruments consist primarily of cash and cash equivalents, accounts receivable, accounts payable and long-term debt. The carrying amounts of the Company's cash and cash equivalents, accounts receivable and accounts payable approximate fair value due to their short-term nature. The fair value of long-term debt is estimated based on current interest rates offered to the Company for financing arrangements with similar maturities. The recorded value of these financial instruments approximate their fair value at December 31, 1998 and 1999.

FOREIGN CURRENCY TRANSLATION

In accordance with Statement of Financial Accounting Standards ("SFAS") No. 52, "Accounting for Foreign Exchange," all balance sheet accounts of foreign subsidiaries are translated into United States dollars at the current exchange rate, and income statement items are translated at the average exchange rate for the period; resulting translation adjustments are made directly to accumulated other comprehensive income (loss) in stockholders' equity. Realized exchange gains and losses are included in current operations and were not material.

F-9

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

2. Summary of Significant Accounting Policies (Continued)
REVENUE RECOGNITION

Revenue is recognized from system sales when a product is accepted by the customer, except when sold through an independent distributor, a strategic collaboration partner or an unconsolidated Bruker affiliate which assumes responsibility for installation, in which case the system sale is recognized upon shipment from the Company's facilities. Revenue from accessories and parts is recognized upon shipment, and revenue from services when performed.

The Company also offers to its customers warranty and service agreements extending beyond the initial year of warranty for a fee. These fees are recorded as deferred revenue and amortized into income over the life of the agreements.

Other revenues, which are principally comprised of research and development grants, are recognized as grant work is performed.

ADVERTISING COSTS

Advertising costs are expensed as incurred. Advertising expenses included in sales and marketing were $452,466 and $363,567 for the years ended December 31, 1998 and 1999, respectively.

INCOME TAXES

The Company provides for income taxes under the liability method prescribed by SFAS No. 109, "Accounting for Income Taxes." Under this method, deferred tax assets and liabilities are determined based on the difference between the financial statements and tax basis of assets and liabilities using enacted tax rates in effect for the year in which the difference is expected to reverse. Valuation allowances are established when necessary to reduce deferred tax assets to the amounts expected to be realized.

ACCOUNTING DEVELOPMENTS

In June 1998, the Financial Accounting Standards Board ("FASB") issued SFAS No. 133, "Accounting for Derivative Instruments and Hedging Activities." The provisions of the statement require the recognition of all derivatives as either assets or liabilities in the statement of financial position and the measurement of those instruments at fair value. The accounting for changes in the fair value of a derivative depends on the intended use of the derivative and the resulting designation. The Company is required to implement the statement in the first quarter of fiscal 2001. The Company does not believe that this new accounting standard will have a material impact on the financial statements.

In fiscal 1999, the Company adopted SFAS No. 131, "Disclosures about Segments of an Enterprise and Related Information." The statement established annual and interim reporting standards for an enterprise's operating segments and related disclosures about its products and services, geographic areas and major customers. The adoption of the statement did not affect the results of operations or financial position of the Company.

F-10

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

3. Acquisitions

BRUKER DALTONIK GMBH

Effective December 21, 1998, Bruker Daltonics Inc. acquired all the assets of Bruker Daltonik GmbH formerly known as Bruker Franzen Analytik GmbH (a manufacturer of mass spectrometers) for $5,435,012 funded through the issuance of 5,750,000 shares of common stock for $1.00 per share to existing shareholders. The operations of Bruker Daltonik GmbH and its subsidiary, Bruker Saxonia Analytik GmbH, based in Germany, are included in the 1998 combined statements of operations for comparative purposes. The transaction represented an exchange between entities under common control and, accordingly, the assets acquired and liabilities assumed have been accounted for at historical cost in a manner similar to a pooling-of-interests.

PROTEIGENE, INC.

On December 6, 1999, the Company acquired a 49% interest in ProteiGene, Inc. from an officer of the Company for $50,000, the estimated fair market value. ProteiGene is a bioanalytical research and development company specializing in applications of mass spectrometry and bioinformatics in medical and microbiologic diagnostics. ProteiGene is developing products to be used in the care of patients suffering from routine and exotic infections, organ transplant rejection, and genetic and environmental diseases including cancers and auto-immune conditions where standard microbiologic and histopathologic diagnostics have proven ineffective.

VIKING INSTRUMENTS CORPORATION

On June 22, 1999, the Company purchased, out of bankruptcy court, the assets of Viking Instruments Corporation, a developer and manufacturer of transportable gas chromatrograph mass spectrometers (GC/MS). These transportable GC/MS instruments are used for laboratory and field analysis of soil, air and water for the identification and quantification of a wide variety of organic compounds and pollutants. The acquisition cost was $150,000, and the results of operations are included in the accompanying consolidated financial statements from the date of acquisition.

The pro forma net sales and results of operations for the ProteiGene and Viking Instruments acquisitions, had they occurred at the beginning of 1998, are not significant, and accordingly, have not been provided.

F-11

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

4. Inventories

The components of inventories were as follows:

                                                          December 31,
                                                   ---------------------------
                                                       1998           1999
                                                   ------------   ------------
Raw materials....................................  $ 3,924,861    $ 5,849,464
Work-in-process..................................    8,833,788     10,776,494
Finished goods...................................    4,275,024      8,815,886
                                                   -----------    -----------
                                                   $17,033,673    $25,441,844
                                                   ===========    ===========

5. Property, Plant and Equipment

Property, plant and equipment consisted of the following:

                                                        December 31,
                                                 ---------------------------
                                                     1998           1999
                                                 ------------   ------------
Land...........................................  $  1,726,893   $  1,480,358
Buildings......................................    26,975,800     24,165,161
Office furniture, machinery and equipment......    18,443,195     18,327,638
Leasehold improvements.........................        11,085         11,085
                                                 ------------   ------------
                                                   47,156,973     43,984,242
Less accumulated depreciation and
  amortization.................................   (18,791,393)   (18,633,699)
                                                 ------------   ------------
                                                 $ 28,365,580   $ 25,350,543
                                                 ============   ============

Depreciation expense for the years ended December 31, 1998 and 1999 was $2,464,693 and $3,317,282, respectively. Amortization of leasehold improvements is included with depreciation in the accompanying financial statements.

6. Income Taxes

The components of income (loss) from continuing operations before provision for income taxes consisted of the following for the years ended December 31, 1998 and 1999:

                                                     Year Ended December 31,
                                                    -------------------------
                                                       1998          1999
                                                    -----------   -----------
United States.....................................  $   229,908   $(1,527,000)
Foreign...........................................   (1,118,588)    3,389,929
                                                    -----------   -----------
                                                    $  (888,680)  $ 1,862,929
                                                    ===========   ===========

F-12

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

6. Income Taxes (Continued) Significant components of the provision for income taxes for the years ended December 31, 1998 and 1999 were as follows:

                                                      Year Ended December 31,
                                                     --------------------------
                                                        1998            1999
                                                     ----------       ---------
Current:
  Federal..........................................  $  96,536        $     --
  State............................................     11,464              --
  Foreign..........................................         --          72,000
                                                     ---------        --------
                                                       108,000          72,000
                                                     ---------        --------

Deferred:
  Federal..........................................    (26,000)             --
  State............................................    (82,000)             --
  Foreign..........................................         --         914,887
                                                     ---------        --------
                                                      (108,000)        914,887
                                                     ---------        --------
      Total income taxes on continuing operations..  $      --        $986,887
                                                     =========        ========

The reconciliation of income tax computed at the United States federal statutory tax rate to income tax expense for the years ended December 31, 1998 and 1999 was as follows:

                                                      Year Ended December 31,
                                                     --------------------------
                                                        1998            1999
                                                     ----------       ---------
Income tax (benefit) at statutory rate.............       34.0%           34.0%
Add (deduct):
  Change in valuation allowance....................      (30.5)           35.6
  Permanent differences............................       (1.6)            1.2
  Foreign income tax at differing rates............         --            (8.9)
  Other............................................       (1.9)           (9.0)
                                                     ---------        --------
                                                            --            52.9%
                                                     =========        ========

F-13

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

6. Income Taxes (Continued) The components of the Company's deferred income taxes were as follows:

                                                          December 31,
                                                    -------------------------
                                                       1998          1999
                                                    -----------   -----------
Deferred tax assets:
  Inventory.......................................  $   301,000   $   880,000
  Warranty accrual................................       55,000       257,000
  Allowance for doubtful accounts.................       10,000        11,000
  R & D tax credit carryforward...................      175,000       225,000
  Net operating loss carryforward.................       29,000       171,000
  Other...........................................       49,000       456,000
                                                    -----------   -----------
                                                        619,000     2,000,000
Valuation allowance...............................      (99,000)     (763,000)
                                                    -----------   -----------
Net deferred tax..................................      520,000     1,237,000

Deferred tax liabilities:
  Patent litigation costs.........................   (2,793,000)   (4,023,000)
  Excess tax over book depreciation...............   (5,998,000)   (4,939,000)
  Other...........................................      (27,000)     (162,000)
                                                    -----------   -----------
Total deferred tax liabilities....................   (8,818,000)   (9,124,000)
                                                    -----------   -----------
Net deferred tax liability........................  $(8,298,000)  $(7,887,000)
                                                    ===========   ===========

For financial reporting purposes, a valuation allowance of $99,000 and $763,000 for December 31, 1998 and 1999, respectively, has been recognized to offset deferred tax assets since uncertainty exists with respect to future realization of deferred tax assets.

As of December 31, 1999, the Company had approximately $225,000 and $428,000 of research and development tax credits and net operating loss carryforwards, respectively, available to reduce future federal tax liabilities. These credits expire at various dates through the year 2019.

Undistributed earnings of foreign subsidiaries aggregated approximately $8.1 million at December 31, 1999, which, under existing law, will not be subject to United States tax until distributed as dividends. Because the earnings have been or are intended to be indefinitely reinvested in foreign operations, no provision has been made for United States income taxes that may be applicable thereto.

7. Financing Arrangements

In August 1999, the Company entered into a revolving line of credit with Citizens Bank in the amount of $2,500,000. This line, which is secured by certain inventory, receivables and equipment in the United States, is used to provide working capital and expires July 31, 2001. Interest on this line of credit is at the lower of LIBOR plus 175 basis points (7.91% at

F-14

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

7. Financing Arrangements (Continued) December 31, 1999) or the Prime Rate (8.5% at December 31, 1999). There is no commitment fee on the unused portion of the line. As of December 31, 1999, the Company had $1,000,000 outstanding on this line of credit.

The Company also maintained revolving lines of credit in 1998 and 1999, respectively, of approximately $4,200,000 and $6,200,000, among German banks at interest rates ranging between 7.5% and 6.1%. At December 31, 1998 and 1999, $2,941,239 and $1,496,350, respectively, was outstanding against these revolving lines of credit. The lines are secured by certain inventory and accounts receivable in Germany and are renewable in June 2000.

The weighted average interest rate for all outstanding borrowings under the Company's lines of credit was 7.01% and 7.06% at December 31, 1998 and 1999, respectively.

The Company has three notes payable with outstanding balances aggregating $14,982,498 and $12,843,582 as of December 31, 1998 and 1999, respectively. One note ($5,137,434 at December 31, 1999), with an interest rate of 5.10%, is payable in full in 2003. The other two notes ($7,706,148 in the aggregate at December 31, 1999), have an interest rate of 4.65% and are due in 2008. The notes are payable to Commerzbank in Germany. Interest is due monthly and all obligations are collateralized by the land and buildings of Bruker Daltonik GmbH.

8. Segment and Geographic Information

The Company operates in one business segment and engages in the design, manufacturing and marketing of proprietary life science systems, process analysis systems, and analytical instruments based primarily on mass spectrometry technology.

GEOGRAPHIC AREAS

Information concerning principal geographic areas is as follows:

                                                     Year Ended December 31,
                                                   ---------------------------
                                                       1998           1999
                                                   ------------   ------------
NET PRODUCT REVENUES FROM EXTERNAL CUSTOMERS
  Germany........................................  $26,621,316    $31,694,883
  United States..................................   13,535,945     22,166,224
  Other..........................................           --      6,759,242
                                                   -----------    -----------
                                                   $40,157,261    $60,620,349
                                                   ===========    ===========

F-15

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

8. Segment and Geographic Information (Continued) Net product revenues are attributable to geographic areas based on the region of sale.

                                                          December 31,
                                                   ---------------------------
                                                       1998           1999
                                                   ------------   ------------
LONG-LIVED ASSETS (EXCLUDING INTANGIBLE ASSETS)
  Germany........................................  $28,037,374    $24,283,757
  United States..................................      328,206        484,006
  Other..........................................           --        672,935
                                                   -----------    -----------
                                                   $28,365,580    $25,440,698
                                                   ===========    ===========
NET ASSETS
  Germany........................................  $ 9,307,408    $11,320,044
  United States..................................    6,821,503      5,294,422
  Other..........................................           --        357,091
                                                   -----------    -----------
                                                    16,128,911     16,971,557
  Elimination entries............................   (5,788,780)    (6,913,908)
                                                   -----------    -----------
                                                   $10,340,131    $10,057,649
                                                   ===========    ===========

9. Discontinued Operations

In 1999, the Company decided to discontinue its Fourier Transform-Infrared (FT-IR) business. The FT-IR business unit sells and services FT-IR instruments to a variety of markets outside the Company's core technology platform of mass spectrometry. The Company plans to complete the sale of its FT-IR business to Bruker Optik GmbH, an affiliated entity, in the first half of 2000 for a price, which approximates the net book value of the assets and liabilities of the business.

Summary results for the discontinued operations for the years ended December 31, 1998 and 1999 are as follows:

                                                     Year Ended December 31,
                                                  -----------------------------
                                                     1998              1999
                                                  -----------       -----------
Net product revenues............................  $2,853,737        $2,741,815
Total costs and expenses........................  (2,214,492)       (2,119,423)
Provision for income taxes......................    (255,831)         (248,915)
                                                  ----------        ----------
Income from discontinued operations.............  $  383,414        $  373,477
                                                  ==========        ==========

The assets and liabilities of the discontinued operations as of December 31, 1998 and 1999 consisted of inventories ($30,930 and $31,650, respectively) and accounts payable ($24,317 and $146,686, respectively).

F-16

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

10. Related-Party Transactions

The Company is affiliated, through common shareholders, with several other entities which use the Bruker name. The Company and its affiliates have entered into a sharing agreement which provides for the sharing of specified intellectual property rights, services, facilities and other related items.

The Company recognized sales to affiliated entities of $9,804,838 in 1998 and $10,307,416 in 1999 and purchases from affiliated entities of $3,913,662 in 1998 and $3,208,752 in 1999.

In 1998 and 1999, various Bruker affiliates provided administrative and other services (including office space-see note 12) to the Company at a cost of approximately $227,000 and $437,000, respectively, based on its assessment of the estimated fair market value of such services.

11. Employee Benefit Plans

The Company maintains or sponsors various defined contribution retirement plans that cover domestic and international employees. The Company may make contributions to these plans at its discretion. Retirement benefits earned are generally based on years of service and compensation during active employment. Eligibility is generally determined in accordance with local statutory requirements. However, the level of benefits and terms of vesting may vary among plans. The Company contributed $66,110 and $122,548 in 1998 and 1999, respectively.

12. Commitments and Contingencies

LEASES

The Company leases office space from related parties, under agreements expiring on various dates through 2004. The Company's principal office lease expires in 2000. These lease obligations for the next five years are as follows:

2000........................................................  $188,321
2001........................................................     3,971
2002........................................................     3,971
2003........................................................     3,971
2004........................................................     3,971
                                                              --------
                                                              $204,205
                                                              ========

Rent expense for the years ended December 31, 1998 and 1999 was $131,962 and $283,860, respectively.

LICENSE AGREEMENTS

The Company has entered into license agreements allowing the Company to utilize certain patents. If these patents are used in connection with a commercial product sale, the

F-17

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

12. Commitments and Contingencies (Continued) Company pays royalties ranging from 0.15% to 5.00% on the related product revenues. Licensing fees for the years ended December 31, 1998 and 1999 were $146,166 and $178,327, respectively.

GRANTS

The Company has a grant from the National Institute of Standards and Technology (NIST) Advanced Technology Program, which commenced on March 1, 1995 and ran through February 28, 2000. This grant is for the development of a DNA sequencing time-of-flight mass spectrometer with a total project cost of $7 million, of which $3.5 million will be reimbursed from NIST. The Company's expenditures were $1.3 million and $2.1 million in 1998 and 1999, respectively. Amounts reimbursed from NIST were $594,000 and $1 million in 1998 and 1999, respectively, and are classified in other revenues.

The Company's wholly-owned subsidiary, Bruker Daltonik GmbH and its subsidiary Bruker Saxonia Analytik GmbH, are the recipients of six grants from German government authorities. The grants were made in connection with the Company's development of specific spectrometers and components of spectrometers. Total grants awarded amount to $4.8 million and expire through December 31, 2001. Amounts received under these grants during 1998 and 1999 totaled $1.5 million and $3 million, respectively, and are classified in other revenues. Total expenditures related to these grants were $3 million and $3.2 million in 1998 and 1999, respectively.

LEGAL

The Company's wholly-owned subsidiary, Bruker Daltonik GmbH, has a $6.8 million and $5.8 million accrued liability at December 31, 1998 and 1999, respectively, related to certain patent infringement litigation filed by a competitor. In 1997, the competitor initiated an action in the United States District Court of Massachusetts alleging patent infringement against the Company and Hewlett-Packard. The competitor has also filed a request for an investigation of its patent infringement claims with the United States International Trade Commission (ITC) and has filed suit against the Company in Germany, France and the United Kingdom. The Massachusetts patent action has been pending the final determination of the ITC action while the actions in Germany, France and the United Kingdom are on going.

In 1998, the ITC found in favor of the Company and in 1999 the Court of Appeals for the Federal Circuit confirmed, in part, the ITC decision in favor of the Company. The Company has filed counterclaims in relation to these patent claims and in 1999 filed an anti-trust suit against the competitor in Massachusetts Federal Court. The Company believes that it has a meritorious defense to the competitor's claims and intends to vigorously defend itself.

Based on a review of the current facts and circumstances, management of the Company and its subsidiary believe that the amount of the accrued liability is a reasonable estimate of the exposure to loss associated with these matters, representing, principally, anticipated legal fees. While acknowledging the uncertainties of litigation, the Company believes that these

F-18

BRUKER DALTONICS INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

12. Commitments and Contingencies (Continued) matters will be resolved without a material effect on the Company's financial position or results of operations. However, an unfavorable outcome of these matters could result in a material adverse impact on the Company's financial statements.

Other lawsuits, claims and proceedings of a nature considered normal to its businesses are pending against the Company and its subsidiary. The Company believes the outcome of these proceedings will not have a material impact on the Company's financial position or results of operations.

13. Subsequent Events

STOCK SPLIT

On February 14, 2000, the Board of Directors of Bruker Daltonics, Inc. authorized a seven-for-one stock split in the form of a stock dividend. Shareholders of record received six additional shares of common stock for every share they owned. All common shares and per share data in the accompanying financial statements have been restated to reflect the stock split.

STOCK OPTIONS

In February 2000, the Board of Directors adopted and the Stockholders approved the 2000 Stock Option Plan ("the Plan"). The Plan provides for the issuance of up to 2,220,000 shares of Common Stock in connection with stock options or other awards under the Plan. The Plan allows a committee of the Board of Directors (the "Committee") to grant incentive stock options, non-qualified stock options, stock appreciation rights and stock awards (including the use of restricted stock and phantom shares). The Committee has the authority to determine which employees will receive the rewards, the amount of the awards, and other terms and conditions of the award. In February 2000, the Committee granted stock options for 783,135 shares of common stock, which vest over three-to-five year periods.

F-19

Report of BDO, Independent Auditors

The Board of Directors
Bruker Daltonics Inc.

We have audited the accompanying combined balance sheet as of December 31, 1997 of the entities listed in Note 1, and the related combined statements of operations, stockholders' equity, and cash flows for the year then ended. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audit. We did not audit the financial statements of Bruker Daltonics Inc., which statements reflect total assets of approximately $5.5 million as of December 31, 1997 and total revenues of approximately $14.7 million for the year then ended. Those statements were audited by other auditors whose report has been furnished to us, and our opinion, insofar as it relates to data included for Bruker Daltonics Inc., is based solely on the report of other auditors.

We conducted our audit in accordance with auditing standards generally accepted in the United States. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provides a reasonable basis for our opinion.

In our opinion, based on our audit and the report of other auditors, the financial statements referred to above present fairly, in all material respects, the combined financial position at December 31, 1997 of the entities listed in Note 1, and the results of their operations and their cash flows for the year then ended, in conformity with accounting principles generally accepted in the United States.

April 6, 2000

         /s/ BDO von Riegen, Lienau, Sucker & Partner GmbH
                  Wirtschaftsprufungsgesellschaft

    (Sucker)                                         (Dr. Lienau)
Wirtschaftsprufer                                  Wirtschaftsprufer

F-20

Report of Ernst & Young LLP, Independent Auditors

The Board of Directors
Bruker Daltonics Inc.

We have audited the balance sheet of Bruker Daltonics Inc. (formerly Bruker Analytical Systems, Inc.) (the Company) as of December 31, 1997, and the related statements of income, stockholders' equity, and cash flows for the year then ended (not presented separately herein). These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audit.

We conducted our audit in accordance with the auditing standards generally accepted in the United States. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provides a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of Bruker Daltonics Inc. at December 31, 1997, and the results of its operations and its cash flows for the year then ended in conformity with accounting principles generally accepted in the United States.

                                          /s/ ERNST & YOUNG LLP

Boston, Massachusetts
February 3, 2000

F-21

BRUKER DALTONICS INC.

COMBINED BALANCE SHEET

                                                              December 31,
                                                              ------------
                                                                  1997
                                                              ------------
                                  ASSETS

Current assets:
  Cash and cash equivalents.................................  $ 2,021,435
  Accounts receivable, less allowance for doubtful accounts
   of $1,028................................................    2,449,755
  Inventories...............................................   14,436,816
  Deferred tax asset........................................      133,176
  Other assets..............................................      135,743
                                                              -----------
      Total current assets..................................   19,176,925
                                                              -----------

Restricted cash.............................................    6,680,002
Property, plant and equipment, net..........................   26,173,305
Intangible and other assets.................................      218,396
                                                              -----------
          Total assets......................................  $52,248,628
                                                              ===========
                   LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
  Short-term borrowings.....................................  $   182,881
  Accounts payable..........................................    4,290,956
  Due to affiliated companies, net..........................    8,218,007
  Accrued expenses..........................................    1,494,795
  Accrued payroll...........................................    1,340,363
  Customer deposits.........................................   10,470,046
  Warranty reserve..........................................    1,269,862
  Note payable to stockholder...............................       50,000
  Income taxes payable......................................      705,513
                                                              -----------
      Total current liabilities.............................   28,022,423
                                                              -----------

Deferred revenue............................................      381,640
Deferred tax liability......................................    7,323,929
Contingent liabilities......................................    6,650,850

Stockholders' equity:
Bruker Daltonics Inc.
  Common stock $.01 par value, authorized 7,000,000 shares,
   issued and outstanding 5,250,000 shares..................       52,500
  Additional paid-in capital................................      697,500
Bruker Daltonik GmbH
  Common stock no par value, authorized 1 share, issued and
   outstanding 1 share......................................    3,489,184
  Accumulated other comprehensive loss......................   (1,969,494)
  Retained earnings.........................................    7,600,096
                                                              -----------
      Total stockholders' equity............................    9,869,786
                                                              -----------
          Total liabilities and stockholders' equity........  $52,248,628
                                                              ===========

The accompanying notes are an integral part of these statements.

F-22

BRUKER DALTONICS INC.

COMBINED STATEMENT OF OPERATIONS

                                                               Year Ended
                                                              December 31,
                                                              ------------
                                                                  1997
                                                              ------------
Product revenue.............................................  $49,246,709
Other revenue...............................................    1,878,298
                                                              -----------
Net revenue.................................................   51,125,007
Costs and operating expenses:
  Cost of product revenue...................................   24,537,719
  Sales and marketing.......................................    7,178,180
  General and administrative................................    2,119,792
  Research and development..................................    9,166,087
  Patent litigation costs...................................    5,525,306
                                                              -----------
        Total costs and operating expenses..................   48,527,084
Operating income from continuing operations.................    2,597,923
Other income................................................      127,255
Interest expense, net.......................................     (743,199)
                                                              -----------
Income before provision for income taxes....................    1,981,979

Provision for income taxes..................................    1,626,785
                                                              -----------
Income from continuing operations...........................      355,194

Income from discontinued operations, net of income taxes....      208,851
                                                              -----------
Net income..................................................  $   564,045
                                                              ===========

The accompanying notes are an integral part of these statements.

F-23

BRUKER DALTONICS INC.
COMBINED STATEMENT OF STOCKHOLDERS' EQUITY

                                     Common Stock
                               ------------------------                                Accumulated
                                 Bruker       Bruker      Additional                      Other            Total
                               Daltonics     Daltonik      Paid-in      Retained      Comprehensive    Stockholders'
                                  Inc.         GmbH        Capital      Earnings          Loss             Equity
                               ----------   -----------   ----------   -----------   ---------------   --------------
Balance as of December 31,
  1996 (unaudited)...........   $ 7,000     $3,489,184     $ 93,000    $7,036,051      $  (628,822)      $9,996,413
  Issuance of common stock...    45,500             --      604,500            --               --          650,000
  Foreign currency
    translation adjustment...        --             --           --            --       (1,340,672)      (1,340,672)
  Net income.................        --             --           --       564,045               --          564,045
                                                                                                         ----------
  Net comprehensive loss.....        --             --           --            --               --         (776,627)
                                -------     ----------     --------    ----------      -----------       ----------
Balance as of December 31,
  1997.......................   $52,500     $3,489,184     $697,500    $7,600,096      $(1,969,494)      $9,869,786
                                =======     ==========     ========    ==========      ===========       ==========

The accompanying notes are an integral part of these statements.

F-24

BRUKER DALTONICS INC.

COMBINED STATEMENT OF CASH FLOWS

                                                               Year Ended
                                                              December 31,
                                                              ------------
                                                                  1997
                                                              ------------
Operating activities:
Income from continuing operations...........................  $    355,194
Adjustments to reconcile income from continuing operations
  to net cash provided by continuing operations:
  Depreciation and amortization.............................     2,572,850
  Deferred income taxes.....................................     1,024,312
  Changes in operating assets and liabilities:
    Accounts receivable.....................................     4,393,788
    Inventories.............................................      (325,147)
    Other assets............................................       780,460
    Accounts payable and accrued expenses...................     1,556,147
    Warranty reserve........................................    (1,080,366)
    Contingent liabilities..................................     3,585,381
    Income taxes payable....................................       663,583
    Deferred revenue........................................       248,820
    Customer deposits.......................................    (1,409,458)
                                                              ------------
Net cash provided by continuing operations..................    12,365,564
Net cash provided by discontinued operations................       320,904
                                                              ------------
    Net cash provided by operating activities...............    12,686,468
Investing activities:
Purchases of property and equipment.........................    (3,911,879)
                                                              ------------
    Net cash used in investing activities...................    (3,911,879)

Financing activities:
Payments on line of credit..................................    (5,399,472)
Changes in due to affiliated companies......................    (5,366,415)
Issuance of common stock....................................       650,000
                                                              ------------
    Net cash used in financing activities...................   (10,115,887)
Effect of exchange rate changes.............................      (403,760)
                                                              ------------
Net decrease in cash and cash equivalents...................    (1,745,058)
Cash and cash equivalents at beginning of year..............     3,766,493
                                                              ------------
Cash and cash equivalents at end of year....................  $  2,021,435
                                                              ============
Supplemental cash flow information:
  Cash paid for interest....................................  $  1,252,112
  Cash paid for income taxes................................       517,461

The accompanying notes are an integral part of these statements.

F-25

BRUKER DALTONICS INC.

NOTES TO COMBINED FINANCIAL STATEMENTS

1. Description of Business

These financial statements represent the combined accounts of Bruker Daltonics Inc. (formally Bruker Analytical Systems, Inc.) and Bruker Daltonik GmbH (formally Bruker-Franzen Analytik GmbH) including its subsidiary Bruker Saxonia Analytik GmbH (collectively "Bruker Daltonics" or the "Company"), for the year ended December 31, 1997. All significant intercompany accounts and transactions have been eliminated in combination.

The Company designs, manufactures and markets proprietary life science systems based on its mass spectrometry core technology platforms. The Company also sells a broad range of field analytical systems for pathogen identification and substance detection. The Company maintains major technical centers in Europe and North America. Bruker Daltonics allocates substantial amounts to research and development and are parties to various collaborations and strategic alliances. The Company's diverse customer base includes pharmaceutical and biotechnology companies, academic institutions and government agencies.

2. Summary of Significant Accounting Policies

USE OF ESTIMATES

The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.

CASH AND CASH EQUIVALENTS

The Company considers all highly liquid investments with original maturities of 90 days or less at date of purchase to be cash equivalents. Cash and cash equivalents are carried at cost, which approximates fair market value at year end. The Company has repurchase agreements with a bank. The repurchase agreements are collateralized by investments principally consisting of U.S. Government Agency securities in the amount of at least 100% of such obligation.

RESTRICTED CASH

At December 31, 1997, $6,680,002 of cash was restricted as part of an advance deposit for a product distribution agreement between Bruker Daltonik GmbH and Hewlett-Packard Company (HP). The Company withdrew amounts for payment as products were delivered and accepted by HP.

CONCENTRATION OF CREDIT RISK

Financial instruments which subject the Company to credit risk consist of cash and cash equivalents and accounts receivables. The risk with respect to cash and cash equivalents is minimized by the Company's policy of investing in short-term financial instruments issued by highly-rated financial institutions. The risk with respect to accounts receivable is minimized by

F-26

BRUKER DALTONICS INC.

NOTES TO COMBINED FINANCIAL STATEMENTS (Continued)

2. Summary of Significant Accounting Policies (Continued) the credit worthiness of the Company's customers. The Company performs periodic credit evaluations of its customers' financial condition and generally does not require collateral. Credit losses have been within management's expectations. For the year ended December 31, 1997, two customers accounted for an aggregate of 31% of the Company's product revenue. Accounts receivables, as of December 31, 1997, for these two customers accounted for an aggregate of 28% of total receivables.

INVENTORIES

Inventories are stated at the lower of cost or market with cost determined by the first-in, first-out, ("FIFO") method.

Inventories include demonstration equipment which the Company offers to current and potential customers. The Company amortizes its demonstration equipment over a three year period. Amortization expense for demonstration equipment was $105,981 for the year ended December 31, 1997.

PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment are stated at cost and are being depreciated on a straight-line basis over the estimated useful lives of the assets as follows:

Buildings...................................................  25 years
Machinery and equipment.....................................  5--10 years
Furniture and fixtures......................................  3--5 years

SOFTWARE COSTS

Purchased software is capitalized at cost and amortized over the estimated useful life, generally three years. Software developed for use in the Company's products is expensed as incurred and is classified as research and development expense.

OTHER ASSETS

Other assets consist principally of patents and licenses. Patents, patent applications and rights are stated at acquisition cost. Amortization of patents is recorded using the straight-line method over the legal lives of the patents, generally for periods ranging up to ten years. Accumulated amortization of these assets amounted to $694,104 as of December 31, 1997.

LONG-LIVED ASSETS

The Company reviews long-lived assets for impairment, in accordance with Statement of Financial Accounting Standard (SFAS) No. 121, "Accounting for the Impairment of Long-Lived Assets to Be Disposed Of," whenever events or circumstances indicate that the carrying amount of an asset may not be recoverable. Assets are written-down to fair value when the carrying costs exceed this amount. Any impairment losses are determined based upon estimated future cash flows and fair values. To date, no such indicators of impairment have been identified.

F-27

BRUKER DALTONICS INC.

NOTES TO COMBINED FINANCIAL STATEMENTS (Continued)

2. Summary of Significant Accounting Policies (Continued)
WARRANTY COSTS

The Company provides a one year parts and labor warranty with the purchase of equipment. The anticipated cost for this one year warranty is accrued upon recognition of the sale and is included as a current liability on the accompanying balance sheets.

CUSTOMER DEPOSITS

Under the terms and conditions of contracts with certain customers, the Company requires an advance deposit. These deposit amounts are recorded as a liability until revenue is recognized against the specific contract at time of acceptance of the system.

FOREIGN CURRENCY TRANSLATION

In accordance with Statement of Financial Accounting Standards ("SFAS") No. 52, "Accounting for Foreign Exchange," all balance sheet accounts of foreign subsidiaries are translated into United States dollars at the current exchange rate, and income statement items are translated at the average exchange rate for the period; resulting translation adjustments are made directly to accumulated other comprehensive income in stockholders' equity. Realized exchange gains and losses are included in current operations and were not material.

REVENUE RECOGNITION

Revenue is recognized from system sales when a product is accepted by the customer, except when sold through a non-combined Bruker affiliate that assumes responsibility for installation, in which case the system sale is recognized upon shipment. Revenue from accessories and parts is recognized upon shipment, and revenue from services, when actually performed.

The Company also offers to its customers extended warranty and service agreements extending beyond the initial year of warranty for a fee. These fees are recorded as deferred revenue and amortized into income over the life of the contract.

ADVERTISING COSTS

Advertising costs are expensed as incurred. Advertising expenses included in sales and marketing were $256,360 for the year ended December 31, 1997.

RESEARCH AND DEVELOPMENT COSTS

Research and development costs are expensed as incurred.

INCOME TAXES

The Company provides for income taxes under the liability method prescribed by SFAS No. 109, "Accounting for Income Taxes." Under this method, deferred tax assets and liabilities are determined based on the difference between the financial statements and tax basis of

F-28

BRUKER DALTONICS INC.

NOTES TO COMBINED FINANCIAL STATEMENTS (Continued)

2. Summary of Significant Accounting Policies (Continued) assets and liabilities using enacted tax rates in effect for the year in which the difference is expected to reverse. Valuation allowances are established when necessary to reduce deferred tax assets to the amounts expected to be realized.

ACCOUNTING DEVELOPMENTS

In 1997, the Company adopted SFAS No. 130, "Reporting Comprehensive Income," which establishes rules for reporting of comprehensive income and its components. The components of comprehensive income that relate to the Company are net earnings and foreign currency translation adjustments.

In June 1997, the Financial Accounting Standards Board ("FASB") issued SFAS No. 133, "Accounting for Derivative Instruments and Hedging Activities." The provisions of the statement require the recognition of all derivatives as either assets or liabilities in the statement of financial position and the measurement of those instruments at fair value. The accounting for changes in the fair value of a derivative depends on the intended use of the derivative and the resulting designation. The Company is required to implement the statement in the first quarter of fiscal 2001. The Company does not believe that this new accounting standard will have a material impact on the financial statements.

3. Inventories

The components of inventories at December 31, 1997 were as follows:

                                                              December 31,
                                                              ------------
                                                                  1997
                                                              ------------
Raw materials...............................................  $ 3,808,502
Work-in-process.............................................    4,269,997
Finished goods..............................................    6,358,317
                                                              -----------
                                                              $14,436,816
                                                              ===========

4. Property, Plant and Equipment

Property, plant and equipment at December 31, 1997 consisted of the following:

                                                              December 31,
                                                              ------------
                                                                  1997
                                                              ------------
Land........................................................  $  1,118,789
Buildings...................................................    24,899,552
Office furniture, machinery and equipment...................    16,639,063
                                                              ------------
                                                                42,657,404
Less accumulated depreciation...............................   (16,484,099)
                                                              ------------
                                                              $ 26,173,305
                                                              ============

Depreciation expense for the year ended December 31, 1997 was $2,340,780.

F-29

BRUKER DALTONICS INC.

NOTES TO COMBINED FINANCIAL STATEMENTS (Continued)

5. Income Taxes

The components of income before provision for income taxes consisted of the following for the year ended December 31, 1997:

                                                               Year Ended
                                                              December 31,
                                                              -------------
                                                                  1997
                                                              -------------
United States...............................................    $  129,039
Foreign.....................................................     1,852,940
                                                                ----------
                                                                $1,981,979
                                                                ==========

Significant components of the provision (benefit) for income taxes for the year ended December 31, 1997 are as follows:

                                                               Year Ended
                                                              December 31,
                                                              -------------
                                                                  1997
                                                              -------------
Current:
  Federal...................................................    $   14,752
  State.....................................................         3,950
  Foreign...................................................        27,311
                                                                ----------
                                                                    46,013
                                                                ----------
Deferred:
  Federal...................................................       (49,806)
  Foreign...................................................     1,630,578
                                                                ----------
                                                                 1,580,772
                                                                ----------
Total income taxes on continuing operations.................    $1,626,785
                                                                ==========

The reconciliation of income tax computed at the U.S. federal statutory tax rates to income tax expense for the year ended December 31, 1997 was as follows:

                                                               Year Ended
                                                              December 31,
                                                              -------------
                                                                  1997
                                                              -------------
Income tax (benefit) at statutory rate......................    $  674,000
Add (deduct)
  Tax differentials on foreign earnings.....................       985,000
  State income taxes........................................         4,000
  Other.....................................................       (36,215)
                                                                ----------
                                                                $1,626,785
                                                                ==========

F-30

BRUKER DALTONICS INC.

NOTES TO COMBINED FINANCIAL STATEMENTS (Continued)

5. Income Taxes (Continued) The components of the Company's deferred income taxes at December 31, 1997 were as follows:

                                                              December 31,
                                                              -------------
                                                                  1997
                                                              -------------
Deferred tax assets:
  Inventory.................................................   $   131,610
  Warranty accrual..........................................        49,000
  Net operating loss credit carryforward....................     1,523,000
  Other.....................................................       498,637
                                                               -----------
                                                                 2,202,247
Deferred tax liabilities:
  Patent litigation costs...................................    (3,385,000)
  Excess tax over book depreciation.........................    (6,004,000)
  Other.....................................................        (4,000)
                                                               -----------
Total deferred tax liabilities..............................    (9,393,000)
                                                               -----------
Net deferred tax liability..................................   $(7,190,753)
                                                               ===========

As of December 31, 1997, the Company had approximately $3 million of net operating loss tax credit carryforwards available to reduce future tax liabilities. These credits expire through the year 2013.

6. Financing Arrangements

The Company maintains revolving lines of credit, of approximately $5,300,000 among German banks at interest rates ranging between 7.25% and 7.50%. At December 31, 1997, $182,881 were outstanding against these revolving lines of credit. The lines are renewable annually in October 1998.

7. Segment and Geographic Information

The Company operates in one business segment and engages in the design, manufacturing and marketing of proprietary life science systems, process analysis systems, and analytical instruments based primarily on mass spectrometry technology.

F-31

BRUKER DALTONICS INC.

NOTES TO COMBINED FINANCIAL STATEMENTS (Continued)

7. Segment and Geographic Information (Continued)
GEOGRAPHIC AREAS

Information concerning principal geographic areas for 1997 are as follows:

                                                               Year Ended
                                                              December 31,
                                                              -------------
                                                                  1997
                                                              -------------
Net product revenues from external customers
  Germany...................................................   $36,019,815
  United States.............................................    13,226,894
                                                               -----------
  Combined..................................................   $49,246,709
                                                               ===========

Net product revenues are attributable to geographic areas based on the region of sale.

                                                              December 31,
                                                              ------------
                                                                  1997
                                                              ------------
Long-lived assets (excluding intangible assets)
  Germany...................................................  $26,026,746
  United States.............................................      146,559
                                                              -----------
  Combined..................................................  $26,173,305
                                                              ===========
Net assets
  Germany...................................................  $ 9,146,007
  United States.............................................      841,695
                                                              -----------
                                                                9,987,702
  Elimination entries.......................................     (117,916)
                                                              -----------
  Combined..................................................  $ 9,869,786
                                                              ===========

8. Discontinued Operations

The Company plans to complete the sale of its FT-IR business to Bruker Optik GmbH in the first half of 2000. The FT-IR business sells and services FT-IR instruments to a variety of markets, outside the Company's core technology platform of mass spectrometry.

Summary results for the discontinued operations for the year ended December 31, 1997 are as follows:

                                                               Year Ended
                                                              December 31,
                                                              ------------
                                                                  1997
                                                              ------------
Net product revenues........................................   $1,643,857
Total costs and expenses....................................    1,295,352
Provision for income taxes..................................      139,654
                                                               ----------
Income from discontinued operations.........................   $  208,851
                                                               ==========

F-32

BRUKER DALTONICS INC.

NOTES TO COMBINED FINANCIAL STATEMENTS (Continued)

8. Discontinued Operations (Continued) The assets and liabilities of the discontinued operations as of December 31, 1997 consisted of accounts payable of $385,869.

9. Related-Party Transactions

As of December 31, 1997, Bruker Daltonik GmbH has two demand loans outstanding aggregating $8,262,617 to Techneon AG, an affiliated company. The loans, which are unsecured, bear interest at 5.25% and 7.50%.

At December 31, 1997, the Group had a $50,000 demand note to the President of the Group. The note, which is unsecured, bears interest at prime (8.50% at December 31, 1997).

The Company recognized sales to affiliated entities of $14,256,695 and purchases from affiliated entities of $3,019,177 in 1997.

In 1997, Bruker Instruments, Inc., a related party, provided administrative and other services to the Company at a cost of $370,391 based on its assessment of the estimated fair market value of such services.

10. Employee Benefit Plans

The Company maintains or sponsors various defined contribution retirement plans that cover domestic and international employees. The Company may make contributions to these plans at its discretion. Retirement benefits earned are generally based on years of service and compensation during active employment. Eligibility is generally determined in accordance with local statutory requirements. However, the level of benefits and terms of vesting may vary among plans. The Company contributed $49,037 in 1997.

11. Commitments and Contingencies

LEASES

The Company leases office and production space from Bruker Instruments, Inc. under a renewable lease. The term of this lease, which was entered into on June 27, 1996, is for three years and four months with one year extensions thereafter. Total rent expense was $125,123 in 1997.

Future minimum rental payments under the Company's operating lease, excluding real estate taxes, insurance and operating costs paid by the Company, are $131,962, $213,782 and $184,350 for 1998, 1999 and 2000, respectively.

GRANTS

The Company has a grant from the National Institute of Standards and Technology (NIST) Advanced Technology Program, which commenced on March 1, 1995 and runs through February 28, 2000. This grant is for the development of a DNA sequencing time-of-flight mass spectrometer with a total project cost of $7.0 million, of which $3.5 million will be reimbursed from NIST. The Company's expenditures were $953,852 in 1997. Amounts reimbursed from NIST were $487,780, and are classified in other revenues.

F-33

BRUKER DALTONICS INC.

NOTES TO COMBINED FINANCIAL STATEMENTS (Continued)

11. Commitments and Contingencies (Continued) Bruker Daltonik GmbH and its subsidiary Bruker Saxonia Analytik GmbH, are the recipients of five grants from German government authorities. The grants were made in connection with the Company's development of specific spectrometers and components of spectrometers. Grants range from $1,203,382 to $6,183,027 and aggregate $16,483,699. The grants expire from December 31, 1997 through January 31, 2001. Aggregate expenditures during the year ended December 31, 1997 totaled $3,744,857. Amounts reimbursed in the aggregate during 1997 totaled $1,390,518 and are classified in other revenues. At December 31, 1997, the Company had no grants receivable.

LEGAL

Various lawsuits, claims and proceedings of a nature considered normal to its businesses are pending against the Company and its subsidiary. The most significant of these are described below.

The Company has a $6.7 million accrued liability at December 31, 1997 related to certain patent infringement litigation filed by a competitor. In 1997, the competitor initiated an action in the United States District Court of Massachusetts alleging patent infringement against the Company and Hewlett-Packard. The competitor has also filed a request for an investigation of its patent infringement claims with the United States International Trade Commission (ITC) and has filed suit against the Company in Germany, France and the United Kingdom. The Massachusetts patent action has been pending the final determination of the ITC action while the actions in Germany, France and the United Kingdom are on going.

Based on a review of the current facts and circumstances, management of the Company believe that the amount of the accrued liability is a reasonable estimate of the exposure to the loss associated with these matters, representing, principally, anticipated legal fees. While acknowledging the uncertainties of litigation, the Company believes that these matters will be resolved without a material effect on the Company's financial position or results of operations. However, an unfavorable outcome of these matters could result in a material adverse impact on the Company's financial statements.

F-34

You should rely only on the information contained in this prospectus. We have not authorized anyone to provide information different from that contained in this prospectus. We are offering to sell, and seeking offers to buy, shares of common stock only in jurisdictions where offers and sales are permitted. The information contained in this prospectus is accurate only as of the date of this prospectus, regardless of the time of delivery of this prospectus or of any sale of our common stock.

TABLE OF CONTENTS

                                     Page
                                   --------
Prospectus Summary...............      2
The Offering.....................      4
Summary Financial Data...........      5
Risk Factors.....................      6
Special Note Regarding
  Forward-Looking Statements.....     17
Use of Proceeds..................     18
Dividend Policy..................     18
Capitalization...................     19
Dilution.........................     20
Selected Financial Data..........     21
Management's Discussion and
  Analysis of Financial Condition
  and Results of Operations......     23
Business.........................     29
Management.......................     44
Principal Stockholders...........     40
Related Transactions.............     51
Description of Capital Stock.....     54
Shares Eligible for Future
  Sale...........................     57
Underwriting.....................     58
Tax Matters......................     61
Legal Matters....................     65
Experts..........................     65
Where You Can Find More
  Information....................     65
Index to Financial Statements....    F-1

Until , 2000 (25 days after the date of this prospectus), all dealers that buy, sell or trade in these securities, whether or not participating in this offering, may be required to deliver a prospectus. Dealers are also obligated to deliver a prospectus when acting as underwriters and with respect to their unsold allotments or subscriptions.

[LOGO]

Shares

Common Stock

Deutsche Banc Alex. Brown

Warburg Dillon Read LLC

Thomas Weisel Partners LLC

Prospectus

, 2000


PART II. INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 13. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

The estimated expenses (other than the underwriting discount) payable in connection with the sale of the common stock offered hereby are as follows, all of which will be paid by the Company:

                                                               AMOUNT
                                                              --------
SEC registration fee........................................  $33,000
NASD filing fee.............................................     *
Nasdaq National Market fee..................................     *
Printing expenses...........................................     *
Legal fees and expenses.....................................     *
Accounting fees and expenses................................     *
Transfer agent and registrar fees and expenses..............     *
Miscellaneous...............................................     *
                                                              -------
Total.......................................................  $  *
                                                              =======


* To be completed by amendment.

ITEM 14. INDEMNIFICATION OF DIRECTORS AND OFFICERS

Section 145 of the General Corporation Law of the State of Delaware provides as follows:

A corporation may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the corporation) by reason of the fact the he is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent or another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by him in connection with such action, suite or proceeding if he acted in good faith and in a manner he reasonably believed to be in or not opposed to the best interest of the corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe his conduct was unlawful. The termination of any action, suit or proceeding by judgment, order, settlement, conviction or upon a plea of nolo contendere or its equivalent, shall not, of itself, create a presumption that the person did not act in good faith and in a manner which he reasonably believed to be in or not opposed to the best interests of the corporation, and, with respect to any criminal action or proceeding, had reasonable cause to believe that his conduct was unlawful.

A corporation may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right of the corporation to procure a judgment in its favor by reason of the fact that he is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise against expenses (including attorney's fees) actually and reasonably incurred by him in connection with the defense or settlement of such action or suit if he acted in good faith and a manner he reasonably believed to in or not opposed to the best interest of the corporation and except that no indemnification shall be made in respect to any claim, issue or matter as to which such person shall have been adjudged to be

II-1


liable to the corporation unless and only to the extent that the Court of Chancery or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper.

In addition, pursuant to our certificate of incorporation and bylaws, we shall indemnify our directors and officers against expenses (including judgments or amounts paid in settlement) incurred in any action, civil or criminal, to which any such person is a party by reason of any alleged act or failure to act in his capacity as such, except as to a matter as to which such director or officer shall have been finally adjudged not to have acted in good faith in the reasonable belief that his action was in the best interest of the corporation.

The underwriting agreement between Bruker Daltonics and the underwriters of this offering provides that the underwriters are obligated, under certain circumstances, to indemnify our directors, officers and controlling persons against certain liabilities, including liabilities under the Securities Act. Reference is made to the form of Underwriting Agreement filed at Exhibit 1.1 hereto.

We maintain directors and officers liability insurance for the benefit of our directors and certain of our officers.

ITEM 15. RECENT SALES OF UNREGISTERED SECURITIES

During the three year period ending December 31, 1999, Bruker Daltonics has issued the following securities, none of which has been registered under the Securities Act:

1. On February 1, 1997, we sold 350,000 shares of common stock to Frank H. Laukien for a purchase price of $500 and a capital contribution of $49,500.

2. On June 30, 1997, we sold 1,750,000 shares of common stock to Isolde Laukien for a purchase price of $2,500 and a capital contribution of $247,500; 1,050,000 shares of common stock to Joerg C. Laukien for a purchase price of $1,500 and a capital contribution of $148,500; 1,050,000 shares of common stock to Marc M. Laukien for a purchase price of $1,500 and a capital contribution of $148,500; and 350,000 shares of common stock to Dirk D. Laukien for a purchase price of $500 and a capital contribution of $49,500.

3. On December 21, 1998, we sold 5,750,000 shares of common stock for $11,500 and a capital contribution of $1,138,500 to each of Frank H. Laukien, Isolde Laukien, Joerg C. Laukien, Marc M. Laukien and Dirk D. Laukien.

4. As of April 10, 2000, options to purchase 783,135 shares of common stock were outstanding under Bruker Daltonics' 2000 Stock Option Plan. None of the options are exercisable within 60 days. All of these options were granted in February 2000 to officers, directors, employees and advisors of Bruker Daltonics.

The sales of securities set forth in paragraphs one to three above were exempt from the registration requirements of the Securities Act in reliance on
Section 4(2) thereof, or Regulation D promulgated thereunder, as transactions by an issuer not involving a public offering. The sale of securities set forth in paragraph four above was exempt from the registration requirements of the Securities Act in reliance on Rule 701 promulgated under Section 3(b) of the Securities Act as transactions by an issuer pursuant to compensatory benefit plans and contracts relating to compensation as provided under such Rule 701. The

II-2


granting of stock options described in paragraph four above did not require registration under the Securities Act, or an exemption therefrom, insofar as such grants did not involve a "sale" of securities as such term is used in
Section 2(3) of the Securities Act.

II-3


ITEM 16. EXHIBITS

NO.                                 DESCRIPTION OF DOCUMENTS
---               ------------------------------------------------------------
        *1.1      Form of Underwriting Agreement
         2.1      Asset Purchase Agreement dated July 1, 1996 between the
                  Registrant and Spectrospin AG
         2.2      Share Purchase Agreement dated December 9, 1998 among the
                  Registrant, Bruker Physik AG and the estate of Dr.
                  Guenther R. Laukien
         2.3      Asset Purchase Agreement dated May 28, 1999 between the
                  Registrant and Viking Instruments Corp
         2.4      ProteiGene Share Purchase Agreement dated December 6, 1999
                  between the Registrant and Frank H. Laukien
         2.5      ProteiGene Share Purchase Agreement dated March 1, 2000
                  between the Registrant and Sidney R. Kaufman
         3.1      Amended and Restated Certificate of Incorporation of the
                  Registrant
         3.2      Amended and Restated Bylaws of the Registrant
        *4.1      Specimen stock certificate representing shares of common
                  stock of the Registrant
        *5.1      Opinion of Hutchins, Wheeler & Dittmar, A Professional
                  Corporation
        10.1      2000 Stock Option Plan
        10.2      Sharing Agreement dated as of February 28, 2000 among the
                  Registrant and 13 affiliates of the Registrant
       +10.3      Collaboration and OEM Agreement dated March 6, 2000 between
                  PerkinElmer Instruments LLC and its Affiliates and the
                  Registrant and its Affiliates
       +10.4      Cooperation Agreement dated November 15, 1999 between Bruker
                  Daltonik GmbH and MWG-Biotech AG
       +10.5      License Agreement dated August 10, 1998 between the
                  Registrant and Indiana University's Advanced Research &
                  Technology Institute
        10.6      Lease dated June 27, 1996 between the Registrant and Bruker
                  Instruments, Inc., as amended
       +10.7      ITMS Collaboration Agreement by and between Hewlett-Packard,
                  the Registrant and Bruker Daltonik GmbH, dated April 28,
                  1999
       +10.8      Collaboration Agreement dated December 4, 1997 between
                  Bruker-Franzen Analytik GmbH and Sequenom Instruments GmbH
       *10.9      Agreement by and between the Registrant and Bruker Optik
                  GmbH dated March 30, 2000
        21.1      Subsidiaries of the Registrant
        23.1      Consent of Ernst & Young LLP
        23.2      Consent of BDO
        23.3      Consent of Hutchins, Wheeler & Dittmar, A Professional
                  Corporation (included in Exhibit 5.1)
        24.1      Power of Attorney (included on page II-5)
        27.1      Financial Data Schedule


* To be filed by amendment

II-4


+ Confidential treatment requested as to certain portions, which portions have been omitted and filed separately with the Commission.

All other schedules for which provisions are made in the applicable accounting regulations of the Securities and Exchange Commission are not required under the related instructions or are inapplicable, and therefore have been omitted.

ITEM 17. UNDERTAKINGS

The undersigned registrant hereby undertakes to provide to the underwriters at the closing of this offering specified in the underwriting agreement certificates in such denomination and registered in such names as required by the underwriters to permit proper delivery to each purchaser.

The undersigned registrant hereby undertakes that: (1) for purposes of determining any liability under the Securities Act, the information omitted from the form of prospectus filed as part of this registration statement in reliance upon Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b)(1) or (4) or 497(h) under the Securities Act shall be deemed to be part of this registration statement as of the time it was declared effective; and (2) for the purpose of determining any liability under the Securities Act, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to provisions described in Item 14 above, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.

II-5


SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this amended registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Billerica, Massachusetts, on April 14, 2000.

BRUKER DALTONICS INC.

By:         /s/ FRANK H. LAUKIEN, PH.D.
     -----------------------------------------
              Frank H. Laukien, Ph.D.
       PRESIDENT, CHIEF EXECUTIVE OFFICER AND
                      CHAIRMAN

We, the undersigned officers and directors of Bruker Daltonics, hereby severally constitute and appoint each of Frank H. Laukien and David E. Plunkett to sign for us and in our names in the capacities indicated below, the Registration Statement on Form S-1 filed herewith and any and all pre-effective and post-effective amendments to said Registration Statement, and, in connection with any registration of additional securities pursuant to Rule 464(b) under the Securities Act of 1933, to sign any abbreviated registration statement and any and all amendments thereto, and to file the same, with all exhibits thereto and other documents in connection therewith, in each case, with the Securities and Exchange Commission, and generally do all such things in our names and on our behalf in our capacities consistent with the provisions of the Securities Act of 1933, as amended, and all requirements of the Securities and Exchange Commission.


Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

                 Signature                                     Title                    Date
                 ---------                                     -----                    ----
                                                  President and Chief Executive
        /s/ FRANK H. LAUKIEN, PH.D.               Officer and Chairman of the
-------------------------------------------       Board (Principal Executive       April 14, 2000
          Frank H. Laukien, Ph.D.                 Officer)

           /s/ DAVID E. PLUNKETT                  Chief Financial Officer
-------------------------------------------       (Principal Financial and         April 14, 2000
             David E. Plunkett                    Accounting Officer)

          /s/ DIETER KOCH, PH.D.
-------------------------------------------       Director                         April 14, 2000
            Dieter Koch, Ph.D.

           /s/ BERNHARD WANGLER
-------------------------------------------       Director                         April 14, 2000
             Bernhard Wangler

         /s/ TIMOTHY J. HANSBERRY
-------------------------------------------       Director                         April 14, 2000
           Timothy J. Hansberry

           /s/ WILLIAM A. LINTON
-------------------------------------------       Director                         April 14, 2000
             William A. Linton

            /s/ COLLIN D'SILVA
-------------------------------------------       Director                         April 14, 2000
              Collin D'Silva

           /s/ RICHARD M. STEIN
-------------------------------------------       Director                         April 14, 2000
             Richard M. Stein


EXHIBIT INDEX

NO.                                          DESCRIPTION OF DOCUMENTS
---                        ------------------------------------------------------------
         *1.1              Form of Underwriting Agreement

          2.1              Asset Purchase Agreement dated July 1, 1996 between the
                           Registrant and Spectrospin AG

          2.2              Share Purchase Agreement dated December 9, 1998 among the
                           Registrant, Bruker Physik AG and the estate of Dr.
                           Guenther R. Laukien

          2.3              Asset Purchase Agreement dated May 28, 1999 between the
                           Registrant and Viking Instruments Corp.

          2.4              ProteiGene Share Purchase Agreement dated December 6, 1999
                           between the Registrant and Frank H. Laukien

          2.5              ProteiGene Share Purchase Agreement dated March 1, 2000
                           between the Registrant and Sidney R. Kaufman

          3.1              Amended and Restated Certificate of Incorporation of the
                           Registrant

          3.2              Amended and Restated Bylaws of the Registrant

         *4.1              Specimen stock certificate representing shares of common
                           stock of the Registrant

         *5.1              Opinion of Hutchins, Wheeler & Dittmar, A Professional
                           Corporation

         10.1              2000 Stock Option Plan

         10.2              Sharing Agreement dated as of February 28, 2000 among the
                           Registrant and 13 affiliates of the Registrant

        +10.3              Collaboration and OEM Agreement dated March 6, 2000 between
                           PerkinElmer Instruments LLC and its Affiliates and the
                           Registrant and its Affiliates

        +10.4              Cooperation Agreement dated November 15, 1999 between Bruker
                           Daltonik GmbH and MWG-Biotech AG

        +10.5              License Agreement dated August 10, 1998 between the
                           Registrant and Indiana University's Advanced Research &
                           Technology Institute

         10.6              Lease dated June 27, 1996 between the Registrant and Bruker
                           Instruments, Inc., as amended

        +10.7              ITMS Collaboration Agreement by and between Hewlett-Packard,
                           the Registrant and Bruker Daltonik GmbH, dated April 28,
                           1999

        +10.8              Collaboration Agreement dated December 4, 1997 between
                           Bruker-Franzen Analytik GmbH and Sequenom Instruments GmbH

        *10.9              Agreement by and between the Registrant and Bruker Optik
                           GmbH dated March 30, 2000

         21.1              Subsidiaries of the Registrant

         23.1              Consent of Ernst & Young LLP

         23.2              Consent of BDO

         23.3              Consent of Hutchins, Wheeler & Dittmar, A Professional
                           Corporation (included in Exhibit 5.1)

         24.1              Power of Attorney (included on page II-5)

         27.1              Financial Data Schedule


* To be filed by amendment

+ Confidential treatment requested as to certain portions, which portions

have been omitted and filed separately with the Commission.


Exhibit 2.1

FTMS ASSET PURCHASE AGREEMENT

BETWEEN SPECTROSPIN AG, FALLANDEN,

SWITZERLAND ("SAG"), AND BRUKER ANALYTICAL

SYSTEMS, INC., BILLERICA, MA, USA ("BASI")

1. AS OF JULY 1ST, 1996, BASI HEREBY ASSUME SAG'S LIABILITY, VALUED AS A US $100,000 SAG LIABILITY, FOR PROVIDING SERVICE, INCLUDING WARRANTY SERVICE, SPARE PARTS, AND UPGRADES, TO THE CUSTOMERS LISTED IN ATTACHMENT A, TO WHICH SAG HAS SOLD FOURIER TRANSFORM MASS SPECTROMETRY ("FTMS") EQUIPMENT OVER THE YEARS.

2. SAG HAS TRANSFERRED ITS REMAINING SUBUNIT AND COMPONENT FTMS INVENTORY, UNDER BASI PURCHASE ORDER BE601441, DATED APRIL 11, 1996, WITH A NEGLIGIBLE SAG BOOK VALUE, TO BASI FOR A TOTAL AMOUNT OF $100,000. THIS AMOUNT OF US $100,000 WILL BE THE FINAL AND ONLY INVOICE TO BE ISSUED BY SAG TO BASI FOR BE601441, AND ALL OTHER INVOICES FOR THIS PURCHASE ORDER NO. WILL BE CREDITED OUT BY SAG.

3. AS OF JULY 1ST, 1996, SAG HEREBY TRANSFERS AND / OR EXCLUSIVELY LICENSES TO BASI ALL ITS WORLDWIDE FTMS INTELLECTUAL PROPERTY RIGHTS, INCLUDING BUT NOT LIMITED TO FTMS INVENTIONS, PATENTS, PATENT APPLICATIONS, COPYRIGHTS, TRADEMARKS AND TRADEMARK APPLICATIONS, AND ALL FTMS KNOW-HOW, TRADE-SECRETS, TECHNICAL AND BUSINESS INFORMATION RELATING TO FTMS, VALUED AT US $100,000.

4.       SAG MAKES NO WARRANTIES AND REPRESENTATIONS ABOUT USEABILITY OF
         INVENTORIES, UPPER LIMIT ON TRANSFERRED SERVICE LIABILITY, VALIDITY AND
         ENFORCEABILITY OF INTELLECTUAL PROPERTY, OR ANY OTHER WARRANTY, UNLESS
         EXPLICITLY STATED IN THIS AGREEMENT. BASI DOES NOT ASSUME ANY PRODUCT
         OR PATENT LIABILITY FOR SAG SALES, OR ANY OTHER SAG CONTRACTUAL OR
         OTHER LIABILITY, IF ANY, UNLESS EXPLICITLY AGREED UPON IN THIS
         AGREEMENT.

FOR SAG:                                             FOR BASI:

/s/  WERNER SCHITTENHELM                             /s/  JOHN WRONKA

---------------------------                          ------------------------
WERNER SCHITTENHELM, DIRECTOR                        DR. JOHN WRONKA, V.P.


ATTACHMENT A: LIST OF SAG FTMS CUSTOMERS


Institution and Address                     Installation    Spectrometer
-------------------------                   ------------    -------------
-------------------------                   ------------    -------------

Dr. Rick Willis                             11.95           BioAPEX 47E
Australian Institute of Marine Sciences                     ESI, MALDI, APCI
PMB No. 3                                                   NanoSPRAY
Townsville, M.C.                                            GC, EI/CI, SIMS
Q1d. 4810 AUSTRALIA                                         QEA, Pulsed Valves
Phone: 61 77 789 375
Fax: 61 66 625 752
EMAIL: R_WLLIS@AIMS.GOV.AU

Prof. Jon Amster                            1.96            BioAPEX 70e
University of Georgia                                       ESI and MALDI
Chemistry Department
Athens, GA 30602
Phone: 706 542-2001
Fax: 706-542-9454
EMAIL: amster@sunchem.chem.uga.edu

Prof. Terrance B. McMahon                   6.95            CMS to APEX Upgrade
Department of Chemistry
University of Waterloo
Waterloo, Ontario N2L 3G1 CANADA
Phone: 519 888 4591
Fax: 519 746 0435
EMAIL: mcmahon@watsci.uwaterloo.ca

Prof. Einar Uggerud                         6.95            BioAPEX 47e
University of Oslo                                          ESI and MALDI
Postboks 1033 Blindern                                      EI/CI
N-0315-Oslo                                                 Laser Vaporization Cluster
Norway                                                      Source
Phone: 47 22 85 55 37
Fax: 47 22 85 54 41
email: einar.uggerud@kjemi.uio.no

Prof. Roger Giese                           2.95            APEX 47e with GC/MS
Barnett Institute
Mugar Building
Northeastern University
Boston, MA 02115 USA
Phone: 617 373 3227
Fax: 617 373 8720


Chinese University of Hong Kong        10.94              BioAPEX 47e
Department of Chemistry                                   Electrospray Ionization
Dr. Dominic Chan                                          MALD Ionization
Shatin, New Territories
HONG KONG
Phone: 85 2 2 609 6344
Fax: 85 2 2 603 5057

University of Florida                   2.94              APEX 70e
Department of Chemistry                                   Infinity Cell
Professor John Eyler                                      EI/CI Source
Gainesville, Florida                                      Glow Discharge
USA                                                       Electrospray Ionization
Phone: 904 392-0532
Fax: 904 392-0872

Brigham Young University                1.94              APEX 47e
Department of Chemistry                                   Infinity Cell
Dr. Dave Dearden                                          EI/CI Source
Salt Lake City, Utah                                      Pulsed Valve
USA
Phone: 801 378 2355
Fax: 801 378 5474
EMAIL: deardend@chem.byu.edu

FOM-AMOLF                              11.93              APEX 70e
Atomic and Molecular Physics                              Infinity Cell
Professor Jaap Boon                                       EI/CI Source
Kruislaan 407                                             Pyrolysis Source
1098 SJ Amsterdam
THE NETHERLANDS
Phone: 31 20 608 1234
Fax: 31 20 668 4106
EMAIL: ron@kookaburra.amolf.nl

Prof. Luc VanVaeck                     92                 APEX 47e
Department of Chemistry                                   Laser MicroFocus
University of Antwerp
Universiteitsplein 1
B-2160 Wilrijk
BELGIUM
Phone:  32 3 820 2348
Fax:  32 3 820 2249


Agency for Defense Development              92             APEX 70e
Dept. ATRC-6-6                                             EI/CI Source
Dr. Hwang                                                  SIMS Ionization
Yuseong, Taejon                                            Excimer Laser Dissociation
THE REPUBLIC OF KOREA

University of Rome `La Sapienza'            92             APEX 47e
Institute of Pharmaceutical Chemistry                      Infinity Cell
Professor Fulvio Cacace                                    Nd:YAG Laser Desorption
Piazza Aldo Moro 5                                         EI/CI Source
00185 Rome
ITALY
Phone:  39 49 913 698
Fax:  39 49 913 888

Technical University of Berlin                             CMS 70X
Institute for Organic Chemistry                            EI/CI Source
Professor Helmut Schwarz                                   GC Interface
Strasse des 17 Juni 135                                    FAB Ionization
1000 Berlin                                                Two Pulsed Valves
GERMANY                                                    Laser Desorption
Phone:  49 30 314 23483
Fax:  49 30 314 21102

Technical University of Munich                             CMS 47X
Institute for Physical and Theoretical                     Laser Desorption
    Chemistry
Professor Vladimir Bondybey
Lichtenbergstrasse 4
8046 Garching
GERMANY
Phone:  49 89 3209 3426
Fax:  49 89 3209 3418
Email:  Dr. Gereon Niedner-
Scahttebourg, gereon@anionx.phys.
chemie.tu-muenchen.de


Miami University                               CMS 47X
Dr. Carolyn Cassady                            EI/CI Source
Dept. of Chemistry                             Pulsed Valve
112, Hughes Hall
Oxford, Ohio  45056
USA
Phone:  513 529 2494
Fax:  513 529 1667

University of Waterloo                         CMS 47X
Department of Chemistry                        Infinity Cell
Professor Terry McMahon                        Pulsed Valve
Waterloo, Ontario N2L 3G1
CANADA
Phone:  519 888 4591

University of Bielefeld                        CMS 47X
Faculty for Chemistry                          Infinity Cell
Professor H.-Fr. Gruetzmacher                  EI/CI Source
Universitaetstrasse 25                         Laser Desorption
4800 Bielefeld
GERMANY
Phone:  49 521 106 2072
Fax:  49 521 106 6146
email:  gruetzmacher@chema.uni-
            bielefeld

University of Bremen                           CMS 70
Natural Sciences II                            Laser Desorption
Prof. K.-P. Wanczek
Loebenerstrasse
2800 Bremen 33
GERMANY
Phone:  49 421 218 3402
Fax:  49 421 218 7215

University of Amsterdam                        CMS 47X
Institute for Mass Spectrometry                EI/CI Source
Professor Nico Nibbering                       FAB Ionization
Nieuwe Achtergacht 129
1018 Amsterdam
THE NETHERLANDS
Phone:  31 205 255 457
Fax:  31 205 256 971


Wiomi Pty. Ltd.                                  CMS 47X
Dr. D.M. Kemp                                    GC Interface
P.O. Box 3063                                    SIMS Ionization
0001 Pretoria
SOUTH AFRICA

Ecole Polytechnique                              CMS 47X
Chemistry Department                             EI/CI Source
Prof. Audier                                     Pulsed Valve
91128 Palaiseau
FRANCE
Phone:  33 1 693 34878
Fax:  33 1 693 33010

Academy of Internal Affairs                      CMS 47X
Institute of Criminalistics                      GC Interface
Mrs. Krystyna Zawalska                           FAB Ionization
Ksawerov 13                                      Laser Desorption
00-904 Warsaw
POLAND

SASOL Technology Ltd.                            CMS 47X
Instrumental Techniques                          EI/CI Source
Research & Development                           GC Interface
Dr. Abrie Augustyn                               Laser Desorption
9570 Sasolburg
SOUTH AFRICA

Technical University Darmstadt                   CMS 47
Institute for Physical Chemistry
Dr. Manfred Irion
Petersenstrasse 20
6100 Darmstadt
GERMANY
Phone:  49 61 511 65438
Fax:  49 6151 166015

Consejo Superior de Investigaciones              CMS 47
Cientificas                                      Pulsed Valve
Instituto Rocasolano
Dr. J.-L. Abboud
Serrano 119
28006 Madrid
SPAIN


Russian Academy of Sciences                    CMS 47
Institute of Chemical Physics
Professor V.L. Talrose
Ul. Kosygina 4
117987 Moscow GSP-1
RUSSIA

University of New South Wales                  CMS 47
School of Chemistry                            Solid Probe
Professor Gary Willett                         Nd:YAG Laser Desorption
Kensington 2033
NSW AUSTRALIA
Phone:  61 2 697 4723
Fax:  61 2 662 2835

University of Nice                             CMS 47
Laboratory for Physical Organic
    Chemistry
Dr. Jean-Francois Gal
Parc Valrose
06034 Nice Cedex
FRANCE
Phone:  33 93 529 852
Fax:  33 93 529 919

Institute of Chemical and Biological           CMS 47
   Physics
Professor E.T. Lipmaa
Lenini Priestee 10
2000001 Tallinn
ESTONIA

Institute for Catalysis                        CMS 47
Dr. S. Iwanow
Prospekt Nauki 7
630090 Novosibirsk 90
RUSSIA


EXHIBIT 2.2

CERTIFIED COPY

/crest/

Document

of

Dr. Stiegeler

Notary

Karlsruhe Notary's Offices

Helmholtzstrasse 9 - 76133 Karlsruhe
P. O. Box 46 08 - 76030 Karlsruhe
Telephone: 07 21/9 26-62 63

DOCUMENT REGISTER 2 UR 4682/98

Bruker Daltonics, Inc.,
44 Manning Road, Billerica, MA 01821
USA

Order No. 1115 document cover (VB 2.79)


2 UR 4682/98

PUBLIC DOCUMENT

of

Dr. Stiegeler

Notary

NOTARY'S OFFICE 2, KARLSRUHE

Helmholtzstrasse 9, 76133 Karlsruhe
Telephone: 0721/926-6263

concerning the

TRANSFER OF AN
INTEREST IN A GmbH

PLACE OF NOTARIAL RECORDING:
Helmholtzstrasse 9-11, Karlsruhe

DATE OF NOTARIAL RECORDING:
December ninth,
nineteen hundred ninety-eight

- December 9, 1998 -


Present:

1. Ms. Isolde Laukien nee Mahler, born January 4, 1940, residing at Silberstreifen 8, 76287 Rheinstetten

acting as sole executive of

BRUKER-PHYSIK AKTIENGESELLSCHAFT

located in Rheinstetten (Silberstreifen 4, 76287 Rheinstetten)

listed in the Commercial Register of the Karlsruhe Amtsgericht [District Court], HRB 84.

The notary has certified this power of representation based on inspection of the Commercial Register of the Karlsruhe District Court on December 4, 1998.

2. Mr. Jorg Laukien, born December 10, 1954, residing at Uhlandstrasse 10, 76275 Ettlingen,

acting on his own account, and for account of

the other heirs of the late Prof. Dr. Gunter Rudi Fritz Laukien

as listed in the joint certificate of inheritance dated July 21, 1997 (Notary's Office 2, Karlsruhe - Probate Court - 2 GRN 157/97), the original of which is present today, a photocopy of which is attached to this document, the conformity of which with the original is hereby certified,

based on the power of attorney dated May 15, 1998, submitted in the original, returned, and a photocopy of which is attached to this document, the conformity of which with the original is hereby certified.

3. Mr. Frank H. Laukien, born February 4, 1960, residing at 12 Smith Hill Road, Lincoln, MA 01773, USA,

acting as President and Authorized Representative for

BRUKER DALTONICS, INC., 44 MANNING ROAD, BILLERICA, MASSACHUSETTS 01821

who submitted the originals of the elements of proof adjoining this document.

After their identities were established by means of Federal identity cards/passports, the persons appearing before me made the following declaration:


-3-

AT THE REQUEST OF THE PERSONS APPEARING BEFORE ME, I HEREBY DOCUMENT THEIR DECLARATIONS, WHICH THEY MADE WHILE BEING PRESENT TOGETHER AT THE SAME TIME, AS FOLLOWS:

I.

PRELIMINARY REMARKS

1. The

BRUKER DALTONIK GmbH

company, with headquarters in Bremen, is listed in the Commercial Register of the Bremen District Court HRB 8150.

2. The nominal capital of the company is DM 5,000,000.00.

3. The nominal capital is held as follows:

a)   Bruker Physik AG
     Rheinstetten,
     A participating share in the amount of     DM 1,275,000.00

b)   Community of heirs of Prof. Dr. G. Laukien
     A participating share in the amount of     DM 3,725,000.00

4. According to information from the parties concerned, the nominal capital is fully paid in.


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II.

TRANSFER OF INTEREST

The appearing parties as defined in paragraph 1 above hereby transfer their interest in the amount of DM 1,275,000.00 in the above-mentioned GmbH, along with all rights and in rem components in exclusive rights, to the appearing parties as defined in paragraph 3 above.

The appearing parties as defined in paragraph 2 above hereby transfer their interest in the amount of DM 3,725,000.00 in the above-mentioned GmbH, along with all rights and in rem components in exclusive rights, to the appearing parties as defined in paragraph 3 above.

Agreement has been reached concerning this transfer of rights. The transferee accepts this transfer. Security of the trade relationship is not desired.

III.

TERMS/CONSIDERATION

1. The transfer made today is effective as of today's date.

2. The transferee is entitled to the claim on a pro rata share in annual net profits for previous years and the current year, unless already paid out to the shareholders.

3. The contract price for the transferred interests is DM 9,030,000.00 (in words: nine million thirty thousand). Of that amount, the community of heirs receives DM 6,727,350.00 and Bruker Physik AG receives DM 2,302,650.00.

4. The contract price must be paid by December 31, 1998.

- 5 -

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IV.

GUARANTEE

The transferor guarantees only the existence of the interest, the fact that it is paid up in the amount indicated, and the free and unfettered transfer of rights. More extensive liability, specifically for the quality of the business undertakings of the company, is ruled out.

V.

CONSENT

Pursuant to the partnership agreement, no consent of the company/shareholders is required for today's transfer of interest. By way of precaution, this consent is hereby given.

The manager here present, Mr. Frank Laukien, hereby accepts the application for transfer.

VI.

COSTS

All costs associated with this document and any inheritance taxes shall be paid by the appearing party as defined in paragraph 3 above. The bill of charges shall be sent to the Wangler Law Offices.

VII.

CONCLUSION

The notary informed those present of the Beurkundungsgesetz [Document Authentication Act], specifically section 16 GmbHG [Law on Limited Liability Companies], section 24 GmbHG, and the joint and several liability for costs of the interested parties. According to information provided by the interested parties, the company has real property in Bremen and Leipzig.


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The interested parties expressly waived verification by the notary of the information regarding the content of the partnership agreement.

The notary recommended that tax professionals be consulted for purposes of obtaining tax advice and information.

CONCLUSION:

1. The notary provided the requisite information. Specifically, he informed the parties of the liability of transferors and transferees with respect to shares not fully paid in, the risk of advance performance, as well as the need to document any collateral agreements.

The notary mentioned the duty of the general manager, pursuant to section 40 GmbHG, to file a revised shareholder list with the registration court.

2. The following are to be distributed:

- a certified photocopy to each of the interested parties;
- a certified photocopy to the Bremen Tax Office, pursuant to section 54 EStDV [Income Tax Implementing Regulation] - a certified photocopy for information to: Wangler Law Offices, Kriegsstrasse 133, 76135 Karlsruhe
- announcement of the transfer to the registration court, Bremen District Court

- 2 certified photocopies to the Bremen Tax Office - Real Property Transfer Tax Office -
- 2 certified photocopies to the Leipzig Tax Office
- Real Property Transfer Tax Office -.

The notary read the foregoing document aloud to the interested parties; it was approved by them, and signed by hand by them and by the notary, as follows:

/signatures/


ACKNOWLEDGMENT OF TRANSLATION

April 13, 2000

The undersigned officer of the Registrant hereby acknowledges on behalf of the Registrant that the foregoing translation of the Share Purchase Agreement dated December 9, 1998 among the Registrant, Bruker Physik AG and the estate of Dr. Guenther R. Laukien is a fair and accurate English translation from German of the original executed agreement.

BRUKER DALTONICS INC.

By: /s/ David E. Plunkett
   --------------------------------
Name: David E. Plunkett
Title: Treasurer


Exhibit 2.3

Thomas Kuehn, Ph.D., President
May 28, 1999

May 28, 1999

VIA TELECOPIER (301) 320-1690

Thomas Kuehn, Ph.D., President
Viking Instruments Corporation
c/o Woodmont Asset Management, Inc.
6403 Kirby Road
Bethesda, MD 20817

Dear Dr. Kuehn:

As you are aware, on May 25, 1999, the Bankruptcy Court extended the time to submit offers to purchase the business and assets of Viking Instruments Corporation ("Viking") until June 8, 1999. The following constitutes Bruker's final offer for it or its nominee to acquire from Viking the business and certain assets of Viking for One Hundred Fifty Thousand Dollars ($150,000.00) cash, including an initial advance in the amount of up to Thirty Thousand Dollars ($30,000.00) as post-petition debtor-in-possession financing to be credited to the purchase price (such initial advance being referred to herein as the "DIP Financing"), subject to the terms set forth in this letter. This offer replaces and supercedes all previous offers to Viking.

Bruker continues to believe that a prompt approval of a sale to it and closing of the transaction remain absolutely critical to the viability of this offer. Every day of delay runs the risk of further diminishing the goodwill of Viking and its value as an ongoing business. Bruker believes that this offer is in the best interests of all parties, including Viking's employees, creditors, vendors and customers, and urge that it be considered promptly. It is urgent that the steps referred to below proceed as expeditiously as possible if this transaction is to succeed.


Thomas Kuehn, Ph.D., President
May 28, 1999

I. Objectives

Bruker has certain key objectives which must be realized if this offer to purchase the business and certain assets of Viking is to be consummated.

First, it is critical that the goodwill of the business be preserved. Thus, Bruker would contemplate a closing as soon as practicable but not later than June 23, 1999. In the interim, it is important that satisfactory arrangements be made to preserve relationships with existing customers of Viking.

Second, a significant asset of Viking is its organization. All parties must act quickly if the Viking organization, with its many skills and talents, is to remain intact. As a condition to the closing of the transaction, Bruker would expect that the following Viking employees would become employees of, or consultants to, Bruker: Thomas Kuehn, Ph.D.; Mark Wilson, Ph.D.; Yuchi Huang, Ph.D., Brian Eckenrode, Ph.D.; Paul Groves; and Ken Cope (the "Employees"). As set forth below, Bruker contemplates that, between the time this offer is accepted and the close of business on June 7, 1999, it shall obtain from each of the Employees agreements (on terms acceptable to Bruker in its sole discretion) that the Employees will make themselves available to be employed by, or consultants to, Bruker.

Third, Bruker must be able to acquire the tangible and intangible assets described below free and clear of all liens, claims, interests and encumbrances of any kind. Bruker understands that, on October 29, 1998, Viking filed under Chapter 11 of the United States Bankruptcy Code (the "Bankruptcy Code"). Given Viking's present financial condition, Bruker believes that the transactions outlined in this letter will not be possible except under the umbrella of court supervision.

Fourth, it is contemplated that after the closing Viking's business will be integrated into Bruker as a focused business unit. Brian Abraham, Ph.D. of Bruker will oversee the transition of the assets and business acquired pursuant to this offer to Bruker's operations in Massachusetts.

To accomplish these objectives, Bruker is prepared to purchase certain assets of Viking, and pending consummation of this purchase (and subject to the limitations contained herein) to provide Viking, as additional consideration for the purchase, with the DIP Financing.

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Thomas Kuehn, Ph.D., President
May 28, 1999

II. The Acquisition

A. Assumption of Liabilities. Bruker will not assume any liabilities of Viking of any kind.

B. Included Assets. Bruker will acquire all of Viking's assets other than the Excluded Assets identified below (the "Included Assets"), including, without limitation the following:

a. Intangible Assets. The assets to be acquired include all intangible assets of Viking of every kind, including but not limited to (i) all Viking trademarks and associated goodwill, including registration and applications for registrations, renewals and extensions; (ii) all patents, patent applications, interest in inventions, know-how, trade secrets, confidential information, techniques, specifications, schematics, and logic diagrams including, without limitation, all patents for or related to the Transportable Gas Chromatograph Mass Spectometer; (iii) interest in customer lists, sales prospect lists including, without limitation, all files and records related to transactions with customers of all kinds; (iv) copyrights and interest in copyrightable subject matter, including, without limitation, all works of authorship, software, firmware, microcode, computer programs, documentation and designs, and unregistered trade names including SpectraTrak, SpectraScan, Viking GC/MS, and Viking Instrument; (v) all rights, including without limitation, all intellectual property rights, under Viking's contracts with its employees, contractors and consultants; (vi) all right, title and interest in SpectraScan(TM) Software Operating System for SpectraTrak 573 System including the object and source code and the copyrights thereto; and (vii) all right, title and interest in SpectraTrak(TM) Model 573 Transportable GC/MS Design Package including mechanical design drawings, electrical and wiring harness design drawings and bill of materials.

b. Machinery, Equipment, Furnishing, Fixtures, and Supplies. The transaction would include all machinery, equipment (including, without limitation, computers, printers and laboratory equipment), furniture, fixtures, and supplies of Viking.

c. Work in Process. In addition, the transaction includes an assignment of so much of Viking's present work in process as shall not have been filled as of the closing of this transaction and any additional work in process which may be developed by Viking during the period of the DIP Financing and not filled as of the closing of this transaction, subject to any required consents of third parties (collectively, the "Work In Process"), including but not limited to unfilled purchase orders and other contract rights related to the order from Viking customers for Viking products; provided, however, that Bruker reserves the right not to accept an assignment of those Work In Process orders which Bruker, upon further review and in its sole discretion, determines not to accept for credit or any other reason.

- 3 -

Thomas Kuehn, Ph.D., President
May 28, 1999

Bruker shall notify Viking in writing on or before June 22, 1999 whether it intends not to accept any Work In Process orders.

d. Certain Leases and Executory Contracts. In addition, the transaction would include the assumption and assignment of such leases and executory contracts of Viking as Bruker may deem appropriate, which leases and executory contracts shall be identified by Bruker at any time before closing or within 30 days thereafter. Viking shall take any and all steps, including obtaining any necessary orders from the Bankruptcy Court, and pay any and all cure and/or compensation amounts, necessary to effectuate the assumption and assignment of the identified leases and executory contracts.

e. Inventory. All inventory, including without limitation: all raw materials; all finished products; all manufacturing inventory including, without limitation, all SpectraTrak(TM) Model 573 GL sub-assemblies, SpectraTrak(TM) Model 572 chassis components and GL sub-assemblies and all mechanical, electronic, and vacuum components and parts; all open stock; all service parts inventory including, without limitation, all new and used parts for SpectraTrak(TM) Models 600, 620, SpectraTrak(TM) Model 572 Transportable GC/MS and SpectraTrak(TM) Model 772 Process GC/MS, SpectraScan operating system software master duplication disks for SpectraTrak(TM) Models 620, 672, 572 and 772 and operating, maintenance, specifications, and design documents and manuals for out-of-production ST600, 620, 672, 572, 772 and other prototype products.

f. Listed Assets. Without limiting any of the foregoing, the Included Assets includes the assets listed on the attached Exhibit A.

C. Excluded Assets. The transaction would exclude (1) all causes of action pursuant to Section 544, 547, 548, 549 and 550 of the Bankruptcy Code (11 U.S.C. ss.ss.101 et seq.) ("Avoidance Actions"), (2) any cash of Viking on hand as of the closing of the sale, (3) any accounts receivable and (4) any executory contracts not specifically assumed and assigned to Bruker in accordance with the terms of this Letter Agreement.

D. Purchase Price. In consideration for the Included Assets, Bruker shall pay Viking One Hundred Fifty Thousand Dollars ($150,000.00) (the "Purchase Price") in immediately available funds at the closing of the sale the Assets subject to the satisfaction of the conditions set forth below.

E. Conditions This offer is subject to the following conditions, all of which must be satisfied by the date indicated, or if no date is indicated, prior to the closing, unless waived in writing by Bruker:

- 4 -

Thomas Kuehn, Ph.D., President
May 28, 1999

1. It shall have been accepted in writing by Viking or Viking's successor in interest entitled to so accept by signing and returning to the undersigned a copy of this letter no later than 5:00 p.m. (Boston time) on June 2, 1999.

2. The sale of the Assets shall have been authorized and confirmed by order of a Bankruptcy Court Judge having authority to do so (the "Sale Order") on or before June 8, 1999, upon proper notice to all creditors of Viking's bankruptcy estate and other parties entitled to such notice by the Federal Rules of Bankruptcy Procedure or by the Local Bankruptcy Rules of the United States Bankruptcy Court for the Eastern District of Virginia, or otherwise by operation of law, with the appeal period from such order having finally passed without a notice of appeal having been filed, or each appeal having been dismissed or withdrawn within thirty (30) days after such notice was filed. At Bruker's option, the closing may take place if an appeal is filed, but no stay pending appeal has been issued.

3. The Sale Order referenced above shall have authorized the transfer of title to the Included Assets free and clear of liens, encumbrances, interests, security interests, taxes and adverse claims of every nature and character. To the extent a complaint must be filed in the Bankruptcy Court to accomplish the foregoing, a judgment shall have entered thereon in the Plaintiffs favor and proof of service on all Defendants shall have been filed of record with the Bankruptcy Court. In addition, the Sale Order shall contain a specific finding that Bruker is purchasing the Assets in good faith; (b) be substantially similar to the form of order attached hereto as Exhibit B, and (c) otherwise be satisfactory to Bruker.

4. The DIP Financing shall have been authorized and confirmed by an interim and final order of a Bankruptcy Court Judge having authority to do so (the "DIP Financing Order") entered contemporaneously with the entry of the Sale Order, upon proper notice to all creditors of Viking's bankruptcy estate and other parties entitled to such notice by the Federal Rules of Bankruptcy Procedure or by the Local Bankruptcy Rules of the United States Bankruptcy Court for the Eastern District of Virginia, or otherwise by operation of law, with the appeal period from such order having finally passed without a notice of appeal having been filed, or each appeal having been dismissed or withdrawn within thirty (30) days after such notice was filed. At Bruker's option, funding under the DIP Financing may take place if an appeal is filed, but no stay pending appeal has been issued.

5. The DIP Financing Order shall have authorized the DIP Financing on the terms and conditions set forth below. In addition, the DIP Financing Order shall contain a specific finding that Bruker is furnishing the DIP Financing in good faith; (b) be substantially similar to the form of order attached hereto as Exhibits C, and (c) otherwise be satisfactory to Bruker.

6. A Bankruptcy Court having jurisdiction over Viking's Chapter 11 case and authority to do so shall have entered the Procedure Order (as hereinafter defined).

- 5 -

Thomas Kuehn, Ph.D., President
May 28, 1999

7. After the acceptance of this offer, Bruker shall have met with the Employees and, no later than June 7, 1999, shall have received from each of the Employees agreements that the Employees will make themselves available to be employed by, or consultants to, Bruker on terms acceptable to Bruker.

8. Bruker shall have the right to rescind this Offer if between the date hereof and the Closing there shall be a material adverse change in the condition of the Included Assets, irrespective of whether or not they shall have been insured; provided, however, that Bruker, with respect to each of the Included Assets not in the same condition, shall have the right at its election to complete the purchase contemplated hereby and either (a) become entitled to all insurance proceeds collected or to be collected by reason of damage to or loss of the respective Asset or (b) receive a credit against the Purchase Price for the diminution in the fair market value of the respective Asset by reason of damage to or loss of such Asset. So long as the value of the Assets shall not have been diminished by more than Twenty-Five Thousand Dollars ($25,000.00) in the aggregate as a result of changes in their condition, Bruker shall not exercise its right to rescind this Offer and, thereby terminate this Agreement, but rather will complete the purchase and exercise one of the options above.

9. There shall be no injunction, restraining order, or order of any nature issued by a court of competent jurisdiction, restraining or preventing the carrying out of the transactions contemplated hereby, and no proceeding challenging this transaction shall have been instituted or threatened.

10. Execution of security documentation for the DIP Financing referred to below, in form and substance satisfactory to Bruker.

11. Unless extended by Bruker, as provided below, closing not later than June 23, 1999 (the "Closing Date").

12. By June 7, 1999, Bruker shall have received (a) the certified year-end financials of Viking for fiscal year 1998, and (b) the financials of Viking for January, February and March, 1999 (collectively, the "Financials"); and further said Financials shall not vary from the representations made to Bruker regarding the condition of Viking.

13. Bruker being satisfied (in its absolute discretion) with the results of a due diligence investigation to be completed by Bruker and/or its representative by 6:00 p.m. (Boston time) June 22, 1999 (the "Diligence Deadline") including but not limited to satisfaction that Bruker will have available to it all resources necessary for the continued operation of Viking's business on acceptable terms. If Bruker is not satisfied with its due diligence, it shall so notify Viking in writing by the Diligence Deadline and upon such notice this offer and the Sale Order shall be of no further force or effect, and neither Viking nor Bruker shall have any liability or obligation to the other arising from or related to this offer and the Sale

- 6 -

Thomas Kuehn, Ph.D., President
May 28, 1999

Order and the transaction contemplated hereby, other than in respect of the DIP Financing. In addition, Bruker shall have the right in its sole discretion on or before the Diligence Deadline not to accept any Work In Process order. Bruker shall have no liability for or any obligation under any Work In Process not accepted.

14. On or before the Closing Date, Viking shall obtain authority from the Bankruptcy Court or from its landlord that authorizes Bruker to enter and occupy the premises located at 44901 Falcon Place, Suite 116, Dulles, Virginia (the "Premises") from the Closing Date up to and including August 31, 1999, to operate Viking's business and/or to remove the Included Assets on terms where Bruker's only obligation is to pay on Viking's behalf, in accordance with the terms of its lease for the Premises, the current rent due under that lease for the period from the Closing Date through and including August 31, 1999.

15. Promptly upon Viking's acceptance of this offer, Viking will proceed to seek authority from the Bankruptcy Court (a) to sell the Included Assets and obtain the DIP Financing and otherwise to perform in accordance with this offer and (b) use its best efforts to obtain a Bankruptcy Court order approving the sales procedures described in Article IV of this offer (the "Procedure Order").

F. Closing of Acquisition. There shall be a closing of the acquisition within thirty (30) business days following the entry of the Sale Order of the Bankruptcy Court as contemplated under the Conditions sections of this offer; provided that the closing shall occur no later than June 23, 1999 except as provided below. If the closing shall not have occurred by such date, Bruker shall have the right, at its sole election and from time to time, to extend such period for one or more additional periods of not more than 10 days each by giving written notice thereof to Viking prior to the expiration of the then current period, except that Bruker may not, without the written consent of Viking, extend such period for more than 90 days from the date of this letter. At the closing, Viking shall execute and deliver to Bruker such bills of sale, assignments and other instruments of transfer and documentation as Bruker may request, in form and substance acceptance to Bruker.

III. The DIP Financing

As additional consideration for the purchase contemplated hereby, Bruker would provide to Viking, from and after the entry of the Sale Order through the date of the acquisition, but in any event, no longer than through June 23, 1999, financing for its post-petition operations in an amount not to exceed Thirty Thousand Dollars ($30,000.00), subject to the following terms and conditions:

1. All DIP Financing extended by Bruker to Viking shall bear interest at a rate per annum of 12% (such interest rate being referred to herein as the "Interest Rate"); provided, however, that such interest shall be waived and shall not be payable by Viking except if the closing of the sale of the Included Assets to Bruker shall not

- 7 -

Thomas Kuehn, Ph.D., President
May 28, 1999

have occurred by June 23, 1999, the DIP Financing and all accumulated interest thereon shall be immediately due and payable.

2. No DIP Financing shall be used to pay any pre-petition liabilities, except as otherwise agreed to in writing by Bruker and approved by the Bankruptcy Court.

3. Before the DIP Financing is extended, Bruker must be granted by order of the Bankruptcy Court the following security interests and protections to secure such DIP Financing (including any interest payable pursuant to the provisions of this agreement and reasonable costs of collection, including reasonable attorneys' fees) on such terms and subject to such documentation as shall be acceptable to Bruker:

a. The DIP Financing shall be secured by a first priority security interest and lien in favor of Bruker on all assets of Viking whether now owned or hereinafter acquired, pursuant to ss.364(c)(2) of the Bankruptcy Code, which security interest and lien shall be valid, fully perfected and enforceable by action of law, provided, however, that this security interest and lien shall not extend to Avoidance Actions and shall be subordinate only to Hewlett-Packard Company's security interest on certain Viking assets and securing a claim of not more than $24,000.00;

b. The DIP Financing shall be an obligation of Viking with priority over all administrative expenses of the kind specified in ss.ss.503(b) or 507(b) of the Bankruptcy Code, pursuant to ss.364(c)(1) of the Bankruptcy Code; and

c. Bruker shall be deemed to be a good faith lender, pursuant to ss.364(e) of the Bankruptcy Code.

4. As a condition to such DIP Financing, the Bankruptcy Court must have entered the DIP Financing Order in the form attached as Exhibit C, which among other things, prescribes various events of default and authorizes the borrowing by Viking and granting to Bruker the security interests and protections described above, and Bruker must be provided a certified copy of such orders.

5. During the period any DIP Financing is outstanding, and as a condition to the extension of such DIP Financing by Bruker, Viking shall provide Bruker with copies of Viking's monthly reports of cash flow and expenditures filed with the United States Trustee's office, such copies to be provided to Bruker when and as filed with such office; and, by the third business day of each week, a report substantially the same as such reports filed with the United States Trustee, containing substantially the same information with respect to the preceding week.

6. The proceeds of any DIP Financing provided by Bruker to Viking shall be used and applied only in accordance with a weekly budget of cash receipts and disbursements for the period June 9, 1999 through and including June 23, 1999,

- 8 -

Thomas Kuehn, Ph.D., President
May 28, 1999

prepared by Viking and submitted to Bruker for approval at least twenty-four (24) hours earlier than the earliest to occur of (a) the first date scheduled for a hearing on the DIP Financing and (b) June 8, 1999. Bruker's advances under the DIP Financing shall be made weekly in accordance with the expected needs under such an approved budget. It shall be an event of the default and the full amount of all DIP Financing together with accrued interest at the Interest Rate shall immediately become due if for any individual week, without Bruker's written consent, (1) Viking's actual cash receipts are less than ninety percent (90%) of budgeted cash receipts in any one week or less than eighty-five percent (85%) of budgeted cash receipts from the beginning of the budget through any given date; or
(2) Viking's actual disbursements for any budgeted line item in any one week exceed budgeted amounts for that line item in that week by more than 10%, or (3) Viking's actual disbursements for all budgeted line items on a cumulative basis at any given time during the budget period exceed all budgeted disbursements as of that time by 25%. By Wednesday of each week, Viking shall provide Bruker with a report showing any variance between its actual performance and its budget performance through the prior Friday on a weekly and cumulative basis.

7. Notwithstanding anything to the contrary contained elsewhere herein, all outstanding DIP Financing plus interest at the Interest Rate shall become immediately due and payable upon the sale of all or any material portion of the Included Assets, individually or collectively, to one or more persons or entities other than Bruker or its nominee, or the termination of this offer pursuant to Article II, ss.ss.8 and 13.

8. Any DIP Financing which does not otherwise become due and payable by Viking in accordance with the foregoing provisions shall be repaid by Viking on the sale or other disposition of any assets in which Bruker is granted a security interest hereunder.

9. In addition to any other rights granted to it hereunder, Bruker shall have the right to obtain and make copies of all files and records of Viking related to any assets in which Bruker is granted a security interest hereunder for the purpose of collecting any monies owed to Bruker under the DIP Financing; and, if Viking sells or otherwise disposes of any such assets, it shall make reasonable arrangements to allow Bruker continued access to such files and records for such purposes.

10. As a condition to the DIP Financing, the Bankruptcy Court shall have entered the Sale Order authorizing the sale of the Included Assets to Bruker.

11. At a closing of the sale of the Included Assets to Bruker in accordance with the terms of this offer, the DIP Financing (without interest) shall be credited against the Purchase Price.

IV. Sale of the Assets to a Third Party

- 9 -

Thomas Kuehn, Ph.D., President
May 28, 1999

1. Bruker understands that its offer in this letter will be subject to higher and better counteroffers before the Bankruptcy Court. Notwithstanding this, Bruker, by this offer, has evidenced its strong desire to assist Viking in resolving its immediate financial problems and, in doing so, has incurred, and may in the future incur, material risks and costs, including but not limited to the risks and costs of the DIP Financing, due diligence and negotiations with the Employees which Bruker would not have offered or incurred except as part of its integrated purchase offer set forth herein. Accordingly, in the event that a third party submits a higher and better counteroffer, which is accepted by Viking and approved by the Bankruptcy Court, Viking shall, concurrently with the closing of such third party acquisition, pay or cause to be paid to Bruker: (i) the full amount of all DIP Financing outstanding at the date of such third party closing together with accrued interest at the Interest Rate from the date such DIP Financing was provided plus (ii) the sum of Fifteen Thousand Dollars ($15,000.00), such amount representing an agreed amount to compensate Bruker for its risks, costs and expenses associated with this transaction, including but not limited to attorneys' fees. Furthermore, for a counteroffer to qualify as a higher and better counteroffer, it must be at least five percent (5%) greater than the Purchase Price.

2. Bruker also understands that Viking's acceptance of this offer is subject to the condition that if there are any qualified counter-offers for the Included Assets that the highest and best final offer for the Included Assets shall be determined by traditional auction procedures rather than by the use of sealed bids and hereby consents to such sale procedures.

3. As a condition to this transaction, the Bankruptcy Court must enter the Procedure Order approving the provisions of this Article IV and the time line for this transaction as set forth above such that the Sale Order is entered by June 8, 1999.

- 10 -

Thomas Kuehn, Ph.D., President
May 28, 1999

V. General

1. This agreement shall be governed by the laws of the Commonwealth of Massachusetts, without giving effect to principles of conflicts of laws.

2. This agreement may be executed in multiple counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

3. This agreement may not be amended or modified without the prior written agreement of the parties. No waiver of any provision contained herein shall be effective unless in writing and signed by the party against which such waiver is sought to be enforced, nor shall a waiver in any instance operate as a general waiver unless expressly stated in such signed writing.

4. This agreement shall be binding upon the parties hereto and their respective successors and assigns; provided, however, that Viking may not assign any of its interests hereunder without the prior written consent of Bruker.

5. Neither party shall be liable to the other for any consequential damages arising out of or in connection with this agreement.

6. The provisions of this agreement and any rights, duties and obligations pursuant hereto shall survive (a) the closing contemplated hereby, (b) any sale to a third party, and/or (c) the entry of any order which may be entered (i) confirming any plan of reorganization, (ii) converting this case from Chapter 11 to Chapter 7, or (iii) dismissing this case; and the terms and provisions of this agreement as well as the rights, duties and obligations pursuant hereto shall continue in full force and effect notwithstanding any such sale or the entry of any such order.

7. All notices, requests, demands or other communications required or permitted hereunder shall be in writing and shall be deemed to have been duly given when delivered by hand or mailed, first class certified mail with postage prepaid or by overnight receipted courier service, or when sent by confirmed telefax, to the intended recipient at the address for notices specified below or, as to either party, at such other address as shall be designated by such party in any notice to the other party:

- 11 -

Thomas Kuehn, Ph.D., President
May 28, 1999

If to Bruker:

Frank H. Laukien, Ph.D., President

Bruker Daltonics, Inc.
44 Manning Road
Billerica, MA 01821

with a copy to:

Andrew M. Troop, Esq.

Hutchins, Wheeler & Dittmar

A Professional Corporation
101 Federal Street
Boston, Massachusetts 02110
Fax: (617) 951-1295

If to Viking:

Viking Instruments Corporation
44901 Falcon Place, Suite 116
Dulles, Virginia 20166

Attention: Thomas Kuehn, Ph.D., President Fax:

with a copy to:

John E. Carter, P.C.

10560 Main Street, Suite 311
P.O. Box 890
Fairfax, VA 22030

Fax:

- 12 -

Thomas Kuehn, Ph.D., President
May 28, 1999

VI. Conclusion

Again, if this offer is acceptable, please so indicate by executing a copy of this letter and returning it to Bruker no later than 5:00 p.m. (Boston time) on June 2, 1999. If this offer is not accepted in writing by that time, the offer shall be of no further force or effect.

Very truly yours,

BRUKER DALTONICS, INC.

By:       /s/ Frank H. Laukien
   ------------------------------
          Frank H. Laukien, Ph.D.
          Its President, Duly Authorized

Agreed and Accepted:

By:  /s/ Thomas J. Kuehn
   -------------------------
     Thomas Kuehn, Ph.D.
     Its President, Duly Authorized

Date: June 2, 1999
     --------------

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List of Assets for Sale by Viking Instruments Corporation

1. Transportable Gas Chromatograph Mass Spectrometer Patent
a. International publication #WO 90/15658, "Miniaturized Mass Spectrometer System" Awarded 12/27/90
b. US Patent #5,313,061, "Miniaturized Mass Spectrometer System" Awarded 5/17/94
c. European Patent #0476062, "Miniaturized Mass Spectrometer System" Dated 6/6/90
d. German Patent #690283041.0, "Miniaturized Mass Spectrometer System" Dated 6/6/90
e. UK Patent #2249662, "Miniaturized Mass Spectrometer System" Dated 6/6/90
f. Canada Patent #2,058,763-6, "Miniaturized Mass Spectrometer System" Awarded 4/21/98
g. Japan Patent #Hei-2-509224, "Miniaturized Mass Spectrometer System",
(Pending)

2. SpectraTrak(TM) Model 573 Transportable GC/MS Design Package (Incomplete)
a. Mechanical design drawings
b. Electrical and wiring harness design drawings
c. Bill of materials
d. Operating and maintenance manual not available
e. Assembly drawings or schematics not available
f. Requires HP5973 mass selective detector OEM component kit for manufacture and operation

3. SpectraScan(TM) Software Operating System for SpectraTrak 573 System
(Incomplete)
a. Copyright of user interface and code
b. Master duplication disk
c. Undocumented assembly code
d. Software manual not available
e. Requires OEM version of HP Chemstation 3.x license for operation
f. Requires OEM version of NIST mass spectral library license for operation
g. Requires Windows 95 and other software utility licenses for operation

4. Manufacturing Inventory and Open Stock
a. Miscellaneous SpectraTrak(TM) Model 573 GC subassemblies (2 sets)
b. Miscellaneous SpectraTrak(TM) Model 572 chassis components and GC subassemblies (2 sets)
c. Miscellaneous mechanical, electronic, and vacuum components and parts
d. Inventory excludes any components, parts, and instruments manufactured by Hewlett Packard

5. Service Parts Inventory, Documentation, and Service Contracts
a. Miscellaneous new and used parts for SpectraTrak(TM) Models 600, 620, and 672 Transportable GC/MS (1989-1997) with rack-mounted transport case design
b. Miscellaneous new and used parts for SpectraTrak(TM) Model 572 Transportable GC/MS (1997-1998)
c. Miscellaneous new and used parts for SpectraTrak(TM) Model 772 Process GC/MS (1995-1998)
d. SpectraScan operating system software master duplication disks for SpectraTrak models 620, 672, 572, and 772 (requires HP Chemstation 2.x, Windows 3.1, and other software utility licenses for operation)
e. Operating, maintenance, specifications, and design documents and manuals for out-of-production and obsolete ST600, 620, 672, 572, 772 and other prototype products
f. Service inventory excludes components, parts, and instruments manufactured by Hewlett Packard
g. Current and on-going service contracts and warranty obligations

6. Marketing and Sales Assets
a. Customer list
b. Sales prospect list
c. Product literature and brochure copyrights
d. Unregistered software copyrights
e. Unregistered tradenames: "SpectraTrak", "SpectraScan", "Viking GC/MS",

"Viking Instruments"


Exhibit 2.4

AGREEMENT

This Agreement, dated as of December 6th, 1999, is concluded by and among Frank H. Laukien, with an address at 12 Smith Hill Road, Lincoln, MA 01773 (the "Seller"), and Bruker Daltonics, Inc., a Massachusetts Corporation with its principal place of business at 15 Fortune Drive, Manning Park, Billerica, MA 01821 (the "Buyer").

WHEREAS, the Seller owns fifty thousand (50,000) shares (the "Shares") of the Common Stock, $.01 par value per share, of ProteiGene, Inc., a Delaware corporation (the "Company"); and

WHEREAS, the Buyer desires to purchase from the Seller the Shares,

NOW THEREFORE, in consideration of mutual covenants, promises and agreements contained herein, as well as other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged by each of the parties hereto, and intending to be legally bound hereby, the parties hereto agree as follows:

1.0 PURCHASE AND SALE OF SHARES

No later than December 6th, 1999 (the "Closing"), the Seller will sell to the Buyer the Shares for an aggregate purchase price of fifty thousand dollars ($50,000). At or before the Closing, the Buyer shall make payment of the aggregate purchase price to the Seller and the Seller shall deliver to each Buyer a certificate representing the Shares purchased by the Buyer. The parties shall also exchange such other documents and instruments as may be reasonably requested by any of them.

2.0 REPRESENTATIONS AND WARRANTIES OF THE SELLER

The Seller hereby represents and warrants to the Buyers as follows:

2.1 ORGANIZATION AND CORPORATE POWER. The Company and the Buyer are each duly organized, validly existing and in good standing under the laws of the jurisdictions of their organization and have all requisite power and authority to own their properties and to carry on their businesses as presently conducted. The Company and the Buyer are duly licensed or qualified to do business as a foreign entity in each jurisdiction wherein the character of their property, or the nature of the activities presently conducted by them, makes such qualification necessary.

2.2 AUTHORIZATION. The Seller has all necessary power and has taken, or will take before the Closing, all necessary action required for the due authorization, execution, delivery and performance by the Seller of this Agreement and any other agreements or instruments executed by the Seller in connection herewith or therewith (collectively the "Related Agreements"), the consummation of the transactions contemplated herein or therein, and for the due authorization, issuance and delivery of the Shares. This


Agreement and the Related Agreements will each be a valid and binding obligation of the Seller enforceable in accordance with its respective terms.

2.3 GOVERNMENT APPROVALS. No consent, approval, license or authorization of, or designation, declaration or filing with, any court or governmental authority is or will be required on the part of the Seller in connection with the execution, delivery and performance by the Seller of this Agreement and any of the Related Agreements.

2.4 COMPLIANCE WITH LAWS AND OTHER INSTRUMENTS. The Seller is in compliance with all of the provisions of this Agreement, and in all material respects with the provisions of each mortgage, indenture, lease, license, other agreement or instrument, judgment, decree, judicial order, statute, and regulation by which it is bound or to which any of its properties are subject. The execution, delivery or performance of this Agreement and the Related Agreements with or without the giving of notice or passage of time, or both, will not violate, or result in any breach of, or constitute a default under, or result in the imposition of any encumbrance upon any asset of the Seller or the Company pursuant to any provision of the charter or by-laws of the Seller or the Company, or any statute, rule or regulation, contract, lease, judgment, decree or other document or instrument by which the Seller or the Company is bound or to which any of their respective properties are subject.

2.5 DISCLOSURES. Neither this Agreement, the Related Agreements, nor any other agreement, document or written statement made by the Seller and furnished by the Seller to the Buyer in connection with the transactions contemplated hereby, contains any untrue statement of material fact or omits to state any material fact necessary to make the statements contained herein or therein not misleading.

2.6 SHARES. The Seller owns the entire right, title and interest in and to the Shares, free and clear of any liens and encumbrances of any nature whatsoever. The Shares are validly issued, fully paid and non-assessable.

3.0 REPRESENTATIONS AND WARRANTIES OF THE BUYERS

The Buyer hereby warrants to the Seller the following:

3.1 AUTHORIZATION. The Buyer has all requisite corporate power and authority and has taken all necessary corporate action required for the due authorization, execution, delivery and performance of this Agreement and the Related Agreements and the consummation of the transactions contemplated herein or therein. This Agreement and the Related Agreements to which the Buyer is a party constitute legal, valid and binding obligations of such Buyer, enforceable against such Buyer in accordance with their respective terms.

3.2 GOVERNMENT APPROVALS. No consent, approval, license or authorization of, or designation, declaration or filing with, any court or governmental authority is or


will be required on the part of the Buyer in connection with the execution, delivery and performance by the Buyer of this Agreement and the Related Agreements.

3.3 INVESTMENT REPRESENTATIONS. The Buyer is acquiring the Shares solely for its own account as an investment and not with a view to any distribution or resale thereof in violation of the Securities Act of 1933, as amended (the "Act"). The Buyer has been advised that the Shares have not been registered under the Act or under the provisions of any state securities or "blue sky" law. The Buyer, by accepting the Shares, agrees and acknowledges that it will not transfer such Shares unless such transfer is made (i) pursuant to an effective registration statement under the Act and in compliance with all applicable state securities or "blue sky" laws, or (ii) pursuant to an available exemption from registration under, or otherwise in compliance with the Act and all applicable state securities or "blue sky" laws. The Buyer has been further advised and understands that no public market now exists for any of the securities issued by the Company and that a public market may never exist for the Shares. The Buyer is an accredited investor for purpose of the Act.

4.0 CONDITIONS OF BUYER'S OBLIGATION

4.1 EFFECT OF CONDITIONS. The obligation of the Buyer to purchase and pay for the Shares at or before the Closing shall be subject to the satisfaction of each of the conditions stated in the following Sections of this Article.

4.2 REPRESENTATIONS AND WARRANTIES. The representations and warranties of the Seller contained in this Agreement shall be true and correct on the date of the Closing, with the same effect as though made on and as of that date.

4.3 PERFORMANCE. The Seller shall have performed and complied with all of the agreements, covenants and conditions contained in this Agreement required to be performed at or prior to the Closing.

4.4 NO MATERIAL ADVERSE CHANGE. The business, properties, assets and condition (financial or otherwise) of the Seller and the Company shall not have been materially adversely affected since the date of this Agreement whether by fire, casualty, act of God or otherwise, and there shall have been no other changes in the business, properties, assets, condition (financial or otherwise), management or prospects of the Seller and the Company that would have a material adverse effect on their respective businesses or assets.

5.0 CONDITIONS OF SELLER'S OBLIGATION

5.1 EFFECT OF CONDITIONS. The obligation of the Seller to sell the Shares at the Closing shall be subject at its election to the satisfaction of each of the conditions stated in the following Section of this Article.


5.2 REPRESENTATIONS AND WARRANTIES; PERFORMANCE. The representations and warranties of the Buyer contained in this Agreement shall be true and correct on the date of such Closing with the same effect as though made on and as of that date.

6.0 TERMINATION

This Agreement may be terminated, and the transactions contemplated hereby abandoned, at any time prior to the Closing by the written agreement of the Seller and the Buyer.

7.0 MISCELLANEOUS

7.1 SURVIVAL OF REPRESENTATIONS. The representations, warranties, covenants and agreements made herein or in any certificates or documents executed in connection herewith shall survive for three (3) months after Closing.

7.2 AMENDMENTS AND WAIVERS. Amendments or additions to this Agreement may be made and compliance with any term, covenant, agreement, condition or provision set forth herein may be omitted or waived (either generally or in a particular instance and either retroactively or prospectively) upon the written consent of the Seller and the Buyer.

7.3 NOTICES. All notices, requests, consents, reports and demands shall be in writing and shall be hand delivered, sent by facsimile or other electronic medium, or mailed, postage prepaid, to the Seller or the Buyer at the address set forth below or to such other address as may be furnished in writing to the other parties hereto. All such notices and communications shall be deemed to have been duly given three (3) business days after being deposited in the mail, postage prepaid, if mailed, one (1) business day after being sent by overnight courier, delivery charges prepaid; when receipt acknowledged, if telecopied or sent by electronic medium; and upon delivery, if delivered by hand.

The Seller:              Frank H. Laukien, Ph.D.
                         12 Smith Hill Road
                         Lincoln, MA 01773
                         Fax: 781-259-1235

The Buyers:              Bruker Daltonics, Inc.
                         15 Fortune Drive
                         Billerica, MA 01821
                         Fax: 978-667-0985
                         Attn: President or Treasurer

7.4 EXPENSES. Each party hereto will pay its own expenses in connection with the transactions contemplated hereby.


7.5 COUNTERPARTS. This Agreement may be executed in multiple counterparts, each of which shall constitute an original but all of which shall constitute but one and the same instrument. One or more counterparts of this Agreement or any exhibit hereto may be delivered via telecopier, with the intention that they shall have the same effect as an original counterpart hereof.

7.6 EFFECT OF HEADINGS. The article and section headings herein are for convenience only and shall not affect the construction hereof.

7.7 GOVERNING LAW. This Agreement shall be governed by, and construed and enforced in accordance with, the internal laws of the Commonwealth of Massachusetts without giving effect to the conflicts of laws principles thereof.

IN WITNESS WHEREOF, the parties have executed hereto this Agreement as of the date first written above.

SELLER:

FRANK H. LAUKIEN

By: /s/  Frank H. Laukien
   ---------------------------
BUYER:

BRUKER DALTONICS, INC.

By: /s/  David E. Plunkett
   ---------------------------
   David E. Plunkett


Title:  TREASURER

      ------------------------


Exhibit 2.5

AGREEMENT

This Agreement, dated as of March 1, 2000 by and between Sidney R. Kaufman of Natick, Massachusetts (the "Seller") and Bruker Daltonics Inc., a Delaware corporation with its principal place of business in Billerica, Massachusetts (the "Buyer").

WHEREAS, the Seller owns twenty-six thousand (26,000) shares (the "Shares") of the Common Stock, $.01 par value per share, of the Buyer; and

WHEREAS, the Buyer desires to purchase from the Seller the Shares;

NOW, THEREFORE, in consideration of mutual covenants, promises and agreements contained herein, as well as other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged by each of the parties hereto, and intending to be legally bound hereby, the parties hereto agree as follows:

1.0 PURCHASE AND SALE OF SHARES

No later than March 1, 2000 (the "Closing"), the Seller will sell to the Buyer the Shares for an aggregate purchase price of Twenty-Six Thousand Dollars ($26,000). At or before the Closing, the Buyer shall make payment of the aggregate purchase price to the Seller and the Seller shall deliver to Buyer a certificate representing the Shares purchased by the Buyer. The parties shall also exchange such other documents and instruments as may be reasonably requested by any of them.

2.0 REPRESENTATIONS AND WARRANTIES OF THE SELLER

The Seller hereby represents and warrants to the Buyer as follows:

2.1 GOVERNMENT APPROVALS. No consent, approval, license or authorization of, or designation, declaration or filing with any court or governmental authority is or will be required on the part of the Seller in connection with the execution, delivery and performance by the Seller of this Agreement.

2.2 COMPLIANCE WITH LAWS AND OTHER INSTRUMENTS. The Seller is in compliance with all of the provisions of this Agreement, and in all material respects with the provisions of each mortgage, indenture, lease, license, other agreement or instrument, judgment, decree, judicial order, statute, and regulation by which he is bound or to which any of his properties are subject. The execution, delivery or performance of this Agreement with or without the giving of notice or passage of time, or both, will not violate, or result in any breach of or constitute a default under, or result in the imposition of any encumbrance upon any asset of the Seller pursuant to any statute, rule or regulation, contract, lease, judgment, decree or other document or instrument by which the Seller is bound or to which any of his properties are subject.

2.3 DISCLOSURES. Neither this Agreement nor any other agreement, document or written statement made by the Seller is furnished by the Seller to the Buyer in connection with the transactions contemplated hereby, contains any untrue statement of material fact


or omits to state any material fact necessary to make the statements contained herein or therein not misleading.

2.4 SHARES. The Seller owns the entire right, title and interest in and to the Shares, free and clear of any liens and encumbrances of any nature whatsoever. The Shares are validly issued, fully paid and non-assessable.

3.0 REPRESENTATIONS AND WARRANTIES OF THE BUYERS

The Buyer hereby warrants to the Seller the following:

3.1 AUTHORIZATION. The Buyer has all requisite corporate power and authority and has taken all necessary corporate action required for the due authorization, execution, delivery and performance of this Agreement and the consummation of the transactions contemplated herein. This Agreement constitutes the legal, valid and binding obligations of the Buyer enforceable against Buyer in accordance with its terms.

3.2 GOVERNMENTAL APPROVALS. No consent, approval, license or authorization of, or designation, declaration or filing with, any court or governmental authority is or will be required on the part of the Buyer in connection with the execution, delivery and performance by the Buyer of this Agreement.

4.0 MISCELLANEOUS

4.1 SURVIVAL OF REPRESENTATIONS. The representations, warranties, covenants and agreements made herein or in any certificates or documents executed in connection herewith shall survive for three (3) months after Closing.

4.2 AMENDMENTS AND WAIVERS. Amendments or additions to this Agreement may be made and compliance with any term, covenant, agreement, condition or provision set forth herein may be omitted or waived (either generally or in a particular instance and either retroactively or prospectively) upon the written consent of the Seller and the Buyer.

4.3 EXPENSES. Each party hereto will pay its own expenses in connection with the transactions contemplated hereby.

4.4 COUNTERPARTS. This Agreement may be executed in multiple counterparts, each of which shall constitute an original but all of which shall constitute but one and the same instrument. One or more counterparts of this Agreement or any exhibit hereto may be delivered via telecopier, with the intention that they shall have the same effect as an original counterpart hereof.

4.5. EFFECT OF HEADINGS. The article and section headings herein are for convenience only and shall not affect the construction hereof.

4.6 GOVERNING LAW. This Agreement shall be governed by, and construed and enforced in accordance with, the internal laws of the Commonwealth of Massachusetts without giving effect to the conflicts of laws principles thereof.

-2-

IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written above.

BRUKER DALTONICS INC.

By: /s/ DAVID E. PLUNKETT             /s/ SIDNEY R. KAUFMAN
   ----------------------------       --------------------------------
David E. Plunkett                        Sidney R. Kaufman
Treasurer

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Exhibit 3.1

CERTIFICATE OF INCORPORATION
OF
BRUKER DALTONICS INC.


FIRST: The name of this corporation shall be:

Bruker Daltonics Inc.

SECOND: Its registered office in the State of Delaware is to be located at 1209 Orange Street, in the City of Wilmington, County of New Castle, 19801, and its registered agent at such address is: THE CORPORATION TRUST COMPANY.

THIRD: The purpose or purposes of the corporation shall be:

To carry on any and all business and to engage in any lawful act or activity for which corporations may be organized under the General Corporation Law of Delaware.

FOURTH: The total number of shares of stock which the Corporation shall have authority to issue is 105,000,000 shares, which shares shall be divided into two classes consisting of: (i) 100,000,000 shares of Common Stock (with $.01 par value per share) ("Common Stock") and (ii) 5,000,000 shares of Preferred Stock (with $.01 par value per share) ("Blank Check Preferred Stock").

The designations and the powers, preferences and rights, and the qualifications, limitations or restrictions of the Common Stock and the Preferred Stock shall be as follows:

A. COMMON STOCK

1. VOTING RIGHTS. Except as otherwise required by law or this Certificate of Incorporation, each holder of Common Stock shall have one vote in respect of each share of Common Stock held by him of record on the books of the Corporation for the election of directors and on all matters submitted to a vote of stockholders of the Corporation.

2. DIVIDENDS. The holders of shares of Common Stock shall be entitled to receive, when and if declared by the Board of Directors, out of the assets of the Corporation which are by law available therefor, dividends payable either in cash, in property or in shares of capital stock, subject, however, to the limitations contained in Part B below.

3. DISSOLUTION, LIQUIDATION OR WINDING UP. After distribution in full of the preferential amount, if any, to be distributed to the holders of series of the Blank Check Preferred Stock (in accordance with the relative preferences among such series) in the event of involuntary liquidation, distribution, dissolution or winding-up, of the Corporation, the holders of the Common Stock shall be entitled to receive all of the remaining assets of the Corporation, tangible and intangible, or whatever kind available for distribution to stockholders, ratably in proportion to the number of shares of Common Stock held by them respectively.


B. BLANK CHECK PREFERRED STOCK

1. ISSUANCE. Shares of Blank Check Preferred Stock may be issued from time to time in one or more series as designated by the Board of Directors, each of said series to be distinctly designated. Shares of Blank Check Preferred Stock may be issued when deemed by the Board of Directors to be necessary to protect the Corporation from an actual, threatened or potential hostile or undesired takeover or takeover attempt. All shares of any one series of the Blank Check Preferred Stock shall be alike in every particular, except that there may be different dates from which dividends, if any, thereon shall be cumulative, if made cumulative. The voting powers, if any, and the designations, relative preferences, participating, optional or other special rights or privileges of each such series, and the qualifications, limitations or restrictions thereof, if any, may differ from those of any and all other series at any time outstanding.

2. AUTHORITY OF THE BOARD OF DIRECTORS. The Board of Directors is authorized, subject to limitations prescribed by law and the provisions of this Article FOURTH, to provide for the issuance of the shares of the Blank Check Preferred Stock in series, and by filing a certificate pursuant to the applicable law of the State of Delaware, to establish from time to time the number of shares to be included in each such series, and to fix in the resolution or resolutions providing for the issue of such stock adopted by the Board of Directors of the Corporation the voting powers, if any, and the designations, relative preferences, participating, optional or other special rights or privileges, and the qualifications, limitations or restrictions of such series, including, but without limiting the generality of the foregoing, the following:

(a) The distinctive designation of, and the number of shares of the Blank Check Preferred Stock which shall constitute such series. The designation of a series of preferred stock need not include the words "preferred" or "preference" and may be designated "special" or other distinctive term. Unless otherwise provided in the resolution issuing such series, the number of shares of any series of the Blank Check Preferred Stock may be increased or decreased (but not below the number of shares thereof then outstanding) by the Board of Directors in the manner prescribed by law;

(b) The rate and times at which, and the terms and conditions upon which, dividends, if any, on the Blank Check Preferred Stock of such series shall be paid, the extent of the preference or relation, if any, of such dividends to the dividends payable on any other class or classes, or series of the same or other classes of stock and whether such dividends shall be cumulative or non-cumulative and, if cumulative, the date from which such dividends shall be cumulative;

(c) Whether the series shall be convertible into, or exchangeable for, at the option of the holders of the Blank Check Preferred Stock of such series or the Corporation or upon the happening of a specified event, shares of any other class or classes or any other series of the same or any other class or classes of stock of the Corporation, and the terms and conditions of such conversion or exchange, including provisions for the adjustment of any such conversion rate in such events as the Board of Directors shall determine;

-2-

(d) Whether or not the Blank Check Preferred Stock of such series shall be subject to redemption at the option of the Corporation or the holders of such series or upon the happening of a specified event, and the redemption price or prices and the time or times at which, and the terms and conditions upon which, the Blank Check Preferred Stock of such series may be redeemed;

(e) The rights, if any, of the holders of the Blank Check Preferred Stock of such series upon the voluntary or involuntary liquidation, merger, consolidation, distribution or sale of assets, dissolution or winding-up, of the Corporation;

(f) The terms of the sinking fund or redemption or purchase account, if any, to be provided for the Blank Check Preferred Stock of such series; and

(g) Subject to subparagraph 5 of Paragraph C hereof, whether such series of the Blank Check Preferred Stock shall have full, limited or no voting powers including, without limiting the generality of the foregoing, whether such series shall have the right, voting as a series by itself or together with other series of the Blank Check Preferred Stock or all series of the Blank Check Preferred Stock as a class, to elect one or more directors of the Corporation if there shall have been a default in the payment of dividends on any one or more series of the Blank Check Preferred Stock or under such other circumstances and on such conditions as the Board of Directors may determine.

C. OTHER PROVISIONS.

1. No holder of any of the shares of any class or series of stock or of options, warrants or other rights to purchase shares of any class or series of stock or of other securities of the Corporation shall have any preemptive right to purchase or subscribe for any unissued stock of any class or series or any additional shares of any class or series to be issued by reason of any increase of the authorized capital stock of the Corporation of any class or series, or bonds, certificates of indebtedness, debentures or other securities convertible into or exchangeable for stock of the Corporation of any class or series, or carrying any right to purchase stock of any class or series, but any such unissued stock, additional authorized issue of shares of any class or series of stock or securities convertible into or exchangeable for stock, or carrying any right to purchase stock, may be issued and disposed of pursuant to resolution of the Board of Directors to such persons, firms, corporations or associations (including such holders or others) and upon such terms as may be deemed advisable by the Board of Directors in the exercise of its sole discretion.

2. The relative powers, preferences and rights of each series of the Blank Check Preferred Stock in relation to the powers, preferences and rights of each other series of the Blank Check Preferred Stock shall, in each case, be as fixed from time to time by the Board of Directors in the resolution or resolutions adopted pursuant to authority granted in Paragraph B hereof. The consent, by class or series vote or otherwise, of the holders of such of the series of the Blank Check Preferred Stock as are from time to time outstanding shall not be required for the issuance by the Board of Directors of any other series of the Blank Check Preferred Stock whether or not the powers, preferences and rights of such other series shall be fixed by the Board

-3-

of Directors as senior to, or on a parity with, the powers, preferences and rights of such outstanding series, or any of them; provided, however, that the Board of Directors may provide in the resolution or resolutions as to any series of the Blank Check Preferred Stock adopted pursuant to Paragraph B hereof, the conditions, if any, under which the consent of the holders of a majority (or such greater proportion as shall be fixed therein) of the outstanding shares of such series shall be required for the issuance of any or all other series of the Blank Check Preferred Stock.

3. Subject to the provisions of subparagraph 2 of this Paragraph C, shares of any series of the Blank Check Preferred Stock may be issued from time to time as the Board of Directors of the Corporation shall determine and on such terms and for such consideration as shall be fixed by the Board of Directors.

4. Shares of authorized Common Stock may be issued from time to time as the Board of Directors of the Corporation shall determine and on such terms and for such consideration as shall be fixed by the Board of Directors.

5. The number of authorized shares of Common Stock and of the Blank Check Preferred Stock, without a class or series vote, may be increased or decreased from time to time (but not below the number of shares thereof then outstanding) by the affirmative vote of the holders of a majority of the stock of the Corporation entitled to vote thereon.

FIFTH: The name and mailing address of the sole incorporator is as follows:

  NAME                            MAILING ADDRESS
  ----                            ---------------
Nancy A. Valente                  c/o Hutchins, Wheeler & Dittmar
                                  A Professional Corporation
                                  101 Federal Street
                                  Boston, Massachusetts  02110

The names and mailing addresses of the persons who are to serve as the Directors until the first annual meeting of the stockholders or until successors are elected and qualified are as follows:

  NAME                            MAILING ADDRESS
  ----                            ---------------
Frank H. Laukien                  44 Manning Road
                                  Billerica, MA  01821

Richard M. Stein                  74 Kirkstall Road
                                  Newtonville, MA  02460

Timothy J. Hansberry              97 Adams Street
                                  Lexington, MA  02420

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Bernhard Wangler                  Kriegsstr. 133
                                  76135 Karlsruhe, Germany

Dr. Dieter Koch                   Fahrenheitstrasse 4, D-28359
                                  Bremen, Germany

Collin D'Silva                    2032 Concourse Drive
                                  San Jose, California  95131

William Linton                    2800 Woods Hollow Road
                                  Madison, Wisconsin  53711

The number of Directors shall be fixed from time to time exclusively by the Board of Directors pursuant to a resolution adopted by the Board of Directors. The Directors of the Corporation shall be divided into three classes:
Class I, Class II and Class III. Each class shall consist, as nearly as may be possible, of one-third of the whole number of the Board of Directors. If the Board of Directors is not evenly divisible by three, the Board of Directors shall determine the number of Directors to be elected to each class. The initial members of Class I shall hold office for a term to expire at the Annual Meeting of the Stockholders to be held in 2001; the initial members of Class II shall hold office for a term to expire at the Annual Meeting of the Stockholders to be held in 2002, the initial members of Class III shall hold office for a term to expire at the Annual Meeting of the Stockholders to be held in 2003, and in the case of each class, until their respective successors are duly elected and qualified. At each annual election held commencing with the annual election in 2001, the Directors elected to succeed those whose terms expire shall be identified as being of the same class as the Directors they succeed and shall be elected to hold office for a term to expire at the third Annual Meeting of the Stockholders after their election, and until their respective successors are duly elected and qualified. If the number of Directors changes, any increase or decrease in Directors shall be apportioned among the classes so as to maintain all classes as equal in number as possible, and any additional Director elected to any class shall hold office for a term which shall coincide with the terms of the other Directors in such class and until his successor is duly elected and qualified.

SIXTH: In furtherance and not in limitation of the powers conferred by the laws of the State of Delaware:

A. The Board of Directors of the corporation is expressly authorized to adopt, amend, or repeal the by-laws of the Corporation.

B. Elections of Directors need not be by written ballot unless the by-laws of the corporation shall so provide.

C. The books of the Corporation may be kept at such place within or without the State of Delaware as the by-laws of the Corporation may provide or as may be designated from time to time by the Board of Directors of the Corporation.

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SEVENTH: Whenever a compromise or arrangement is proposed between this corporation and its creditors or any class of them and/or between this corporation and its stockholders or any class of them, any court of equitable jurisdiction within the State of Delaware may, on the application in a summary way of this corporation or of any creditor or stockholder thereof or on the application of any receiver or receivers appointed for this corporation under the provisions of section 291 of Title 8 of the Delaware Code or on the application of trustees in dissolution or of any receiver or receivers appointed for this corporation under the provisions of section 279 of Title 8 of the Delaware Code, order a meeting of the creditors or class of creditors, and/or of the stockholders or class of stockholders of this corporation, as the case may be, to be summoned in such manner as the said court directs. If a majority in number representing three-fourths in value of the creditors or class of creditors, and/or of the stockholders or class of stockholders of this corporation, as the case may be, agree to any compromise or arrangement and to any reorganization of this corporation as a consequence of such compromise or arrangement, the said compromise or arrangement and the said reorganization shall, if sanctioned by the court to which the said application has been made, be binding on all the creditors or class of creditors, and/or on all the stockholders or class of stockholders, of this corporation, as the case may be, and also on this corporation.

EIGHTH: The Corporation hereby elects in this original certificate of incorporation not to be governed by Section 203 of the General Corporation Law of Delaware.

NINTH: Except as stated in Article Tenth of this certificate of incorporation, the corporation reserves the right to amend or repeal any provision contained in this certificate of incorporation, in the manner now or hereafter prescribed by statute, and all rights conferred upon a stockholder herein are granted subject to this reservation.

TENTH: No director shall be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director notwithstanding any provision of law imposing such liability; provided, however, that, to the extent required by applicable law, this provision shall not eliminate the liability of a director (i) for any breach of the director's duty of loyalty to the corporation or its stockholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii) under Section 174 of the General Corporation Law of Delaware, or
(iv) for any transaction from which the director derived an improper personal benefit. No amendment to or repeal of this provision shall apply to or have any effect on the liability or alleged liability of any director for or with respect to any acts or omissions of such director occurring prior to such amendment or repeal.

ELEVENTH: The Corporation is to have perpetual existence.

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IN WITNESS WHEREOF, the undersigned, being the incorporator hereinbefore named, has executed, signed, and acknowledged this certificate of incorporation this 4th day of February, 2000.

/s/  Nancy A. Valente
----------------------------
     Nancy A. Valente
     Sole Incorporator

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Exhibit 3.2

BY-LAWS

OF

BRUKER DALTONICS INC.

(A Delaware Corporation)


BY-LAWS

OF

BRUKER DALTONICS INC.

(A Delaware Corporation)

ARTICLE 1........................................................................4
   Section 1.1  Contents.........................................................4
   Section 1.2  Certificate in Effect............................................4

ARTICLE 2........................................................................4
   Section 2.1  Place............................................................4
   Section 2.2  Annual Meeting...................................................5
   Section 2.3  Notice of Stockholder Business...................................5
   Section 2.4  Special Meetings.................................................6
   Section 2.5  Notice of Meetings...............................................7
   Section 2.6  Affidavit of Notice..............................................7
   Section 2.7  Quorum...........................................................7
   Section 2.8  Voting Requirements..............................................8
   Section 2.9  Proxies and Voting...............................................8
   Section 2.10  Action Without Meeting..........................................8
   Section 2.11  Stockholder List................................................9
   Section 2.12  Record Date....................................................10

ARTICLE 3.......................................................................11
   Section 3.1  Number; Election and Term of Office.............................11
   Section 3.2  Duties..........................................................11
   Section 3.3  Compensation....................................................12
   Section 3.4  Reliance on Books...............................................12

ARTICLE 4.......................................................................12
   Section 4.1  Place...........................................................12
   Section 4.2  Annual Meeting..................................................12
   Section 4.3  Regular Meetings................................................13
   Section 4.4  Special Meetings................................................13
   Section 4.5  Quorum..........................................................13
   Section 4.6  Action Without Meeting..........................................13
   Section 4.7  Telephone Meetings..............................................14

ARTICLE 5.......................................................................15
   Section 5.1  Designation.....................................................15
   Section 5.2  Records of Meetings.............................................16

ARTICLE 6.......................................................................16
   Section 6.1  Method of Giving Notice.........................................16
   Section 6.2  Waiver..........................................................16

ARTICLE 7.......................................................................17
   Section 7.1  In General......................................................17

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   Section 7.2  Election of President, Secretary and Treasurer..................17
   Section 7.3  Election of Other Officers......................................17
   Section 7.4  Salaries........................................................17
   Section 7.5  Term of Office..................................................17
   Section 7.6  Duties of President and Chairman of the Board...................18
   Section 7.7  Duties of Vice President........................................18
   Section 7.8  Duties of Secretary.............................................19
   Section 7.9  Duties of Assistant Secretary...................................19
   Section 7.10  Duties of Treasurer............................................20
   Section 7.11  Duties of Assistant Treasurer..................................20

ARTICLE 8.......................................................................20
   Section 8.1  Directors.......................................................21
   Section 8.2  Officers........................................................22

ARTICLE 9.......................................................................22
   Section 9.1  Issuance of Stock...............................................22
   Section 9.2  Right to Certificate; Form......................................22
   Section 9.3  Facsimile Signature.............................................23
   Section 9.4  Lost Certificates...............................................23
   Section 9.5  Transfer of Stock...............................................24
   Section 9.6  Registered Stockholders.........................................24

ARTICLE 10......................................................................24
   Section 10.1  Third Party Actions............................................24
   Section 10.2  Derivative Actions.............................................25
   Section 10.3  Expenses.......................................................26
   Section 10.4  Authorization..................................................26
   Section 10.5  Advance Payment of Expenses....................................26
   Section 10.6  Non-Exclusiveness..............................................27
   Section 10.7  Insurance......................................................27
   Section 10.8  Constituent Corporations.......................................27
   Section 10.9  Additional Indemnification.....................................28

ARTICLE 11......................................................................28
ARTICLE 12......................................................................28
ARTICLE 13......................................................................29
ARTICLE 14......................................................................29
ARTICLE 15......................................................................29

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BRUKER DALTONICS INC.

BY-LAWS

ARTICLE 1

CERTIFICATE OF INCORPORATION

SECTION 1.1 CONTENTS. The name, location of principal office and purposes of the Corporation shall be as set forth in its Certificate of Incorporation. These By-laws, the powers of the Corporation and of its Directors and stockholders, and all matters concerning the conduct and regulation of the business of the Corporation shall be subject to such provisions in regard thereto, if any, as are set forth in said Certificate of Incorporation. The Certificate of Incorporation is hereby made a part of these By-laws.

SECTION 1.2 CERTIFICATE IN EFFECT. All references in these By-laws to the Certificate of Incorporation shall be construed to mean the Certificate of Incorporation of the Corporation as from time to time amended, including (unless the context shall otherwise require) all certificates and any agreement of consolidation or merger filed pursuant to the Delaware General Corporation Law, as amended.

ARTICLE 2

MEETINGS OF STOCKHOLDERS

SECTION 2.1 PLACE. All meetings of the stockholders may be held at such place either within or without the State of Delaware as shall be designated from time to time by the Board of Directors, the Chairman of the Board of Directors or the President and stated in the notice of the meeting or in any duly executed waiver of notice thereof.

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SECTION 2.2 ANNUAL MEETING. Annual meetings of stockholders, shall be held on the 2nd Tuesday of April in each year, if not a legal holiday, and if a legal holiday, then on the next secular day following, at 10:00 A.M., or at such other date and time as shall be designated from time to time by the Board of Directors, the Chairman of the Board of Directors or the President and stated in the notice of the meeting. If such annual meeting has not been held on the day herein provided therefor, a special meeting of the stockholders in lieu of the annual meeting may be held, and any business transacted or elections held at such special meeting shall have the same effect as if transacted or held at the annual meeting, and in such case all references in these By-laws, except in this
Section 2.2, to the annual meeting of the stockholders shall be deemed to refer to such special meeting.

SECTION 2.3 NOTICE OF STOCKHOLDER BUSINESS. To be properly brought before the meeting, business must be of a nature that is appropriate for consideration at an Annual Meeting and must be (i) specified in the notice of meeting (or any supplement thereto) given by or at the direction of the Board of Directors, or
(ii) otherwise properly brought before the meeting by or at the direction of the Board of Directors, or (iii) otherwise properly brought before the meeting by a stockholder. In addition to any other applicable requirements, for business to be properly brought before the Annual Meeting by a stockholder, the stockholder must have given timely notice thereof in writing to the Secretary of the Corporation. To be timely, each such notice must be given either by personal delivery or by United States mail, postage prepaid, to the Secretary of the Corporation not later than (1) with respect to a matter to be brought before an Annual Meeting of Stockholders or a Special Meeting in Lieu of an Annual Meeting, not later than the close of business on the 90th day nor earlier than the close of business on the 120th day

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prior to the date set forth in the By-laws for the Annual Meeting and (2) with respect to a matter to be brought before a Special Meeting of the Stockholders not in lieu of an Annual Meeting, the close of business on the tenth day following the date on which notice of such meeting is first given to stockholders. The notice shall set forth (i) information concerning the stockholder, including his or her name and address, (ii) a representation that the stockholder is entitled to vote at such meeting and intends to appear in person or by proxy at the meeting to present the matter specified in the notice, and (iii) such other information as would be required to be included in a proxy statement soliciting proxies for the presentation of such matter to the meeting.

Notwithstanding anything in these By-laws to the contrary, no business shall be transacted at the Annual Meeting except in accordance with the procedures set forth in this section; provided, however, that nothing in this section shall be deemed to preclude discussion by any stockholder of any business properly brought before the Annual Meeting in accordance with these By-laws.

SECTION 2.4 SPECIAL MEETINGS. Special meetings of the stockholders, for any purpose or purposes, unless otherwise prescribed by statute or by the Certificate of Incorporation, may be called by the President, the Chairman of the Board, or by the Board of Directors and shall be called by the President or Secretary at the request in writing of a majority of the Directors then in office. Such request shall state the purpose or purposes of the proposed meeting, which need not be the exclusive purposes for which the meeting is called. The stockholder shall not have the right, in their capacity as stockholders, to call a special meeting of the stockholders.

SECTION 2.5 NOTICE OF MEETINGS. A written notice of all meetings of stockholders stating the place, date and hour of the meeting and, in the case of a special meeting, the purpose or

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purposes for which the special meeting is called, shall be given to each stockholder entitled to vote at such meeting. Except as otherwise provided by law, such notice shall be given not less than ten nor more than sixty days before the date of the meeting. Business transacted at any special meeting of stockholders shall be limited to the purposes stated in the notice.

SECTION 2.6 AFFIDAVIT OF NOTICE. An affidavit of the Secretary or an Assistant Secretary or the transfer agent of the Corporation that notice of a stockholders meeting has been given shall, in the absence of fraud, be prima facie evidence of the facts stated therein.

SECTION 2.7 QUORUM. The holders of a majority of the stock issued and outstanding and entitled to vote thereat, present in person or represented by proxy, shall constitute a quorum at all meetings of the stockholders for the transaction of business except as otherwise provided by statute or by the Certificate of Incorporation. If, however, such quorum shall not be present or represented by proxy at any meeting of the stockholders, the stockholders entitled to vote thereat, present in person or represented by proxy, shall have power to adjourn the meeting from time to time, without notice other than announcement at the meeting, except as hereinafter provided, until a quorum shall be present or represented. At such adjourned meeting at which a quorum shall be present or represented any business may be transacted which might have been transacted at the original meeting. If the adjournment is for more than thirty days, or if after the adjournment a new record date is fixed for the adjourned meeting, a notice of the adjourned meeting shall be given to each stockholder of record entitled to vote at the meeting.

SECTION 2.8 VOTING REQUIREMENTS. When a quorum is present at any meeting, the vote of the holders of a majority of the stock having voting power present in person or represented by proxy shall decide any question brought before such meeting, unless the question is one upon

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which by express provision of any applicable statute or of the Certificate of Incorporation, a different vote is required in which case such express provision shall govern and control the decision of such question.

SECTION 2.9 PROXIES AND VOTING. Unless otherwise provided in the Certificate of Incorporation, each stockholder shall at every meeting of the stockholders be entitled to one vote in person or by proxy for each share of the capital stock having voting power held by such stockholder, but no proxy shall be voted on after three years from its date, unless the proxy provides for a longer period. Persons holding stock in a fiduciary capacity shall be entitled to vote the shares so held, and persons whose stock is pledged shall be entitled to vote the pledged shares, unless in the transfer by the pledgor on the books of the Corporation he shall have expressly empowered the Pledgee to vote said shares, in which case only the pledgee, or his proxy, may represent and vote such shares. Shares of the capital stock of the Corporation owned by the Corporation shall not be voted, directly or indirectly.

SECTION 2.10 ACTION WITHOUT MEETING. Unless otherwise provided in the Certificate of Incorporation, until the closing of an underwritten public offering of the Corporation's Common Stock (a "Public Offering") any action referred or permitted to be taken at any annual or special meeting of stockholders may be taken without a meeting, without prior notice and without vote, if a consent in writing, setting forth the action so taken, is signed by the holders of outstanding stock having not less than the minimum number of votes that would be necessary to authorize or take such action at a meeting at which all shares entitled to vote on such action were present and voted. Prompt notice of the taking of corporate action without a meeting by less than unanimous written consent shall be given to those stockholders who have not consented in writing.

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Effective upon the closing of a Public Offering, any action required or permitted to be taken at any annual or special meeting of stockholders may be taken without a meeting, without prior notice and without vote, only if all stockholders entitled to vote on the matter consent to the action in writing and written consents are filed with the records of the meetings of the stockholders. Such consents shall be treated for all purposes as a vote at a meeting.

SECTION 2.11 STOCKHOLDER LIST. The officer who has charge of the stock ledger of the Corporation shall prepare and make, at least ten days before every meeting of stockholders, a complete list of the stockholders entitled to vote at the meeting, arranged in alphabetical order, and showing the address of each stockholder and the number of shares registered in the name of each stockholder. Such list shall be open to the examination of any stockholder, for any purpose germane to the meeting, during ordinary business hours, for a period of at least ten days prior to the meeting either at a place within the city where the meeting is to be held, which place shall be specified in the notice of the meeting, or, if not so specified, at the place where the meeting is to be held. The list shall also be produced and kept at the time and place of the meeting during the whole time thereof, and may be inspected by any stockholder who is present. The original or duplicate stock ledger shall be the only evidence as to who are the stockholders entitled to examine such list, the stock ledger or the books of the Corporation, or to vote in person or by proxy at any meeting of stockholders.

SECTION 2.12 RECORD DATE. In order that the Corporation may determine the stockholders entitled to notice of or to vote at any meeting of stockholders or any adjournment thereof, or to express consent to corporate action in writing without a meeting, or entitled to receive payment of any dividend or other distribution or allotment of any rights, or entitled to exercise any rights

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in respect of any change, conversion or exchange of stock or for the purpose of any other lawful action, the Board of Directors may fix, in advance, a record date, which shall not be more than sixty nor less than ten days before the date of such meeting, nor more than sixty days prior to any other action. A determination of stockholders of record entitled to notice of or to vote at a meeting of stockholders shall apply to any adjournment of the meeting; provided, however, that the Board of Directors may fix a new record date for the adjourned meeting.

If no record date is fixed by the Board of Directors:

(a) The record date for determining stockholders entitled to notice of or to vote at a meeting of stockholders shall be at the close of business on the day next preceding the day on which notice is given, or, if notice is waived, at the close of business on the day next preceding the day on which the meeting is held.

(b) The record date for determining stockholders entitled to express consent to corporate action in writing without a meeting, when no prior action by the Board of Directors is necessary, shall be the day on which the first written consent is expressed.

(c) The record date for determining stockholders for any other purpose shall be at the close of business on the day on which the Board of Directors adopts the resolution relating thereto.

ARTICLE 3

DIRECTORS

SECTION 3.1 NUMBER; ELECTION AND TERM OF OFFICE. There shall be a Board of Directors of the Corporation consisting of not less than one member, the number of members to be determined by resolution of the Board of Directors, unless the Certificate of Incorporation fixes

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the number of Directors, in which case a change in the number of Directors shall be made only by amendment of the Certificate. The Board of Directors shall be divided into such classes for such terms as are provided for in the Certificate of Incorporation. Subject to any limitation which may be contained within the Certificate of Incorporation, the number of the Board of Directors may be increased at any time by vote of a majority of the Directors then in office. The Directors shall be elected at the annual meeting of the stockholders at which the term of office of the class to which they have been elected expires, except as provided in paragraph (c) of Section 8.1, and each Director elected shall hold office until his successor is elected and qualified or until his earlier resignation or removal. Directors need not be stockholders.

SECTION 3.2 DUTIES. The business of the Corporation shall be managed by or under the direction of its Board of Directors which may exercise all such powers of the Corporation and do all such lawful acts and things as are not by statute or by the Certificate of Incorporation or by these By-laws directed or required to be exercised or done by the stockholders.

SECTION 3.3 COMPENSATION. Unless otherwise restricted by the Certificate of Incorporation or these By-laws, the Board of Directors shall have the authority to fix the compensation of Directors. The Directors may be paid their expenses, if any, of attendance at each meeting of the Board of Directors and may be paid a fixed sum for attendance at each meeting of the Board of Directors or a stated salary as Directors. No such payment shall preclude any Director from serving the Corporation in any other capacity and receiving compensation therefor. Members of special or standing committees may be allowed like compensation for attending committee meetings.

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SECTION 3.4 RELIANCE ON BOOKS. A member of the Board of Directors or a member of any committee designated by the Board of Directors shall, in the performance of his duties, be fully protected in relying in good faith upon the books of account or reports made to the Corporation by any of its officers, or by an independent certified public accountant, or by an appraiser selected with reasonable care by the Board of Directors or by any committee, or in relying in good faith upon other records of the Corporation.

ARTICLE 4

MEETINGS OF THE BOARD OF DIRECTORS

SECTION 4.1 PLACE. The Board of Directors of the Corporation may hold meetings, both regular and special, either within or without the State of Delaware.

SECTION 4.2 ANNUAL MEETING. The first meeting of each newly elected Board of Directors shall be held immediately following the annual meeting of stockholders or any special meeting held in lieu thereof, and no notice of such meeting shall be necessary to the newly elected Directors in order legally to constitute the meeting.

SECTION 4.3 REGULAR MEETINGS. Regular meetings of the Board of Directors may be held without notice at such time and at such place as shall from time to time be determined by the Board.

SECTION 4.4 SPECIAL MEETINGS. Special meetings of the Board may be called by the President on two days' notice to each Director either personally or by mail or by email; special meetings shall be called by the President or Secretary in like manner and on like notice on the written request of two Directors unless the Board consists of only one Director, in which case

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special meetings shall be called by the President or Secretary in like manner and on like notice on the written request of the sole Director.

SECTION 4.5 QUORUM. At all meetings of the Board a majority of the Directors then in office shall constitute a quorum for the transaction of business and the act of a majority of the Directors present at any meeting at which there is a quorum shall be the act of the Board of Directors, except as may be otherwise specifically provided by statute or by the Certificate of Incorporation. If a quorum shall not be Present at any meeting of the Board of Directors, the Directors present thereat may adjourn the meeting from time to time, without notice other than announcement at the meeting, until a quorum shall be present.

SECTION 4.6 ACTION WITHOUT MEETING. Unless otherwise restricted by the Certificate of Incorporation or these By-laws, any action required or permitted to be taken at any meeting of the Board of Directors or of any committee thereof may be taken without a meeting, if all members of the Board or committee, as the case may be, consent thereto in writing, and the writing or writings are filed with the minutes of proceedings of the Board or committee.

SECTION 4.7 TELEPHONE MEETINGS. Unless otherwise restricted by the Certificate of Incorporation or these By-laws, members of the Board of Directors, or any committee designated by the Board of Directors, may participate in a meeting of the Board of Directors, or any committee, by means of conference telephone or similar communications equipment by means of which all persons participating in the meeting can hear each other, and such participation in a meeting shall constitute presence in person at the meeting.

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ARTICLE 5

COMMITTEES OF DIRECTORS

SECTION 5.1 DESIGNATION.

(a) The Board of Directors may, by resolution passed by a majority of the whole Board, designate one or more committees, including, if the Board of Directors deems appropriate, an audit committee and a compensation committee, each committee to consist of one or more of the Directors of the Corporation. The Board may designate one or more Directors as alternate members of any committee, who may replace any absent or disqualified member at any meeting of the committee.

(b) In the absence or disqualification of a member of a committee, the member or members thereof present at any meeting and not disqualified from voting, whether or not he or they constitute a quorum, may unanimously appoint another member of the Board of Directors to act at the meeting in the place of any such absent or disqualified member.

(c) Any such committee, to the extent provided in the resolution of the Board of Directors designating the committee, shall have and may exercise all the powers and authority of the Board of Directors in the management of the business and affairs of the corporation, and may authorize the seal of the Corporation to be affixed to all papers which may require it; but no such committee shall have the power or authority in reference to amending the Certificate of Incorporation, adopting an agreement of merger or consolidation, recommending to the stockholders the sale, lease or exchange of all or substantially all of the Corporation's property and assets, recommending to the stockholders a dissolution of the Corporation or a revocation of a dissolution, or amending the By-laws of the Corporation; and, unless the resolution or the

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Certificate of Incorporation expressly so provide, no such committee shall have the power or authority to declare a dividend or to authorize the issuance of stock. Such committee or committees shall have such name or names as may be determined from time to time by resolution adopted by the Board of Directors.

SECTION 5.2 RECORDS OF MEETINGS. Each committee shall keep regular minutes of its meetings and report the same to the Board of Directors when required.

ARTICLE 6
NOTICES

SECTION 6.1 METHOD OF GIVING NOTICE. Whenever, under any provision of the law or of the Certificate of Incorporation or of these By-laws, notice is required to be given to any Director or stockholder, such notice shall be given in writing by the Secretary or the person or persons calling the meeting by leaving such notice with such Director or stockholder at his residence or usual place of business or by mailing it addressed to such Director or stockholder, at his address as it appears on the records of the Corporation, with postage thereon prepaid, and such notice shall be deemed to be given at the time when the same shall be deposited in the United States mail. Notice to Directors may also be given by email.

SECTION 6.2 WAIVER. Whenever any notice is required to be given under any provision of law or of the Certificate of Incorporation or of these By-laws, a waiver thereof in writing, signed by the person or persons entitled to said notice, whether before or after the time stated therein, shall be deemed equivalent thereto. Attendance of a person at a meeting shall constitute a waiver of notice of such meeting, except when the person attends the meeting for the express purpose of

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objecting at the beginning of the meeting to the transaction of any business because the meeting is not lawfully called or convened.

ARTICLE 7

OFFICERS

SECTION 7.1 IN GENERAL. The officers of the Corporation shall be chosen by the Board of Directors and shall include a President, a Secretary and a Treasurer. The Board of Directors may also choose a Chairman of the Board, one or more Vice Presidents, Assistant Secretaries and Assistant Treasurers. Any number of offices may be held by the same person, unless the Certificate of Incorporation or these By-laws otherwise provide.

SECTION 7.2 ELECTION OF PRESIDENT, SECRETARY AND TREASURER. The Board of Directors at its first meeting after each annual meeting of stockholders shall choose a President, a Secretary and a Treasurer.

SECTION 7.3 ELECTION OF OTHER OFFICERS. The Board of Directors may appoint such other officers and agents as it shall deem appropriate who shall hold their offices for such terms and shall exercise such powers and perform such duties as shall be determined from time to time by the Board.

SECTION 7.4 SALARIES. The salaries of all officers and agents of the Corporation may be fixed by the Board of Directors.

SECTION 7.5 TERM OF OFFICE. The officers of the Corporation shall hold office until their successors are chosen and qualify or until their earlier resignation or removal. Any officer elected or appointed by the Board of Directors may be removed at any time in the manner specified in Section 8.2.

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SECTION 7.6 DUTIES OF PRESIDENT AND CHAIRMAN OF THE BOARD. The Chairman
of the Board shall be the Chief Executive Officer of the Corporation. The President shall report to the Chairman of the Board and the Chief Executive Officer and shall preside at all meetings of the stockholders and, if he is a Director, at all meetings of the Board of Directors. Subject to the control and direction of the Directors, the President shall have general and active management of the business of the Corporation and shall see that all orders and resolutions of the Board of Directors are carried into effect. The President shall execute bonds, mortgages and other contracts requiring a seal, under the seal of the Corporation, except where required or permitted by law to be otherwise signed and executed and except where the signing and execution thereof shall be expressly delegated by the Board of Directors to some other officer or agent of the Corporation. The Chairman of the Board, if any, shall make his counsel available to the other officers of the Corporation, shall be authorized to sign stock certificates on behalf of the Corporation, shall preside at all meetings of the Directors at which he is present, and, in the absence of the President at all meetings of the stockholders, and shall have such other duties and powers as may from time to time be conferred upon him by the Directors.

SECTION 7.7 DUTIES OF VICE PRESIDENT. In the absence of the President or in the event of his inability or refusal to act, the Vice President (or in the event there be more than one Vice President, the Vice Presidents in the order designated by the Directors, or in the absence of any designation, then in the order of their election) shall perform the duties of the President not otherwise conferred upon the Chairman of the Board, if any, and when so acting, shall have all the powers of and be subject to all the restrictions upon the President. The Vice Presidents shall

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perform such other duties and have such other powers as the Board of Directors may from time to time prescribe.

SECTION 7.8 DUTIES OF SECRETARY. The Secretary shall attend all meetings of the Board of Directors and all meetings of the stockholders and record all the proceedings of the meetings of the Corporation and of the Board of Directors in a book to be kept for that purpose and shall perform like duties for the standing committees when required. He shall give, or cause to be given, notice of all meetings of the stockholders and special meetings of the Board of Directors, except as otherwise provided in these By-laws, and shall perform such other duties as may be prescribed by the Board of Directors or President, under whose supervision he shall be. He shall have charge of the stock ledger (which may, however, be kept by any transfer agent or agents of the Corporation under his direction) and of the corporate seal of the Corporation.

SECTION 7.9 DUTIES OF ASSISTANT SECRETARY. The Assistant Secretary, or if there be more than one, the Assistant Secretaries in the order determined by the Board of Directors (or if there be no such determination, then in the order of their election) shall, in the absence of the Secretary or in the event of his inability or refusal to act, perform the duties and exercise the powers of the Secretary and shall perform such other duties and have such other powers as the Board of Directors may from time to time prescribe.

SECTION 7.10 DUTIES OF TREASURER. The Treasurer shall have the custody of the corporate funds and securities and shall keep full and accurate accounts of receipts and disbursements in books belonging to the Corporation and shall deposit all moneys and other valuable effects in the name and to the credit of the Corporation in such depositories as may be designated by the Board of Directors. The Treasurer shall disburse the funds of the Corporation as may be ordered by the

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Board of Directors, taking proper vouchers for such disbursements, and shall render to the President and the Board of Directors, at its regular meetings, or when the Board of Directors so requires, an account of all of his transactions as Treasurer and of the financial condition of the Corporation. If required by the Board of Directors, he shall give the Corporation a bond in such sum and with such surety or sureties as shall be satisfactory to the Board of Directors for the faithful performance of the duties of this office and for the restoration to the Corporation, in case of his death, resignation, retirement or removal from office, of all books, papers, vouchers, money and other property of whatever kind in his possession or under his control belonging to the Corporation.

SECTION 7.11 DUTIES OF ASSISTANT TREASURER. The Assistant Treasurer, or if there shall be more than one, the Assistant Treasurers in the order determined by the Board of Directors (or if there be no such determination, then in the order of their election), shall, in the absence of the Treasurer or in the event of his inability or refusal to act, perform the duties and exercise the powers of the Treasurer and shall perform such other duties and have such other powers as the Board of Directors may from time to time prescribe.

ARTICLE 8

RESIGNATIONS, REMOVALS AND VACANCIES

SECTION 8.1 DIRECTORS.

(a) RESIGNATIONS. Any Director may resign at any time by giving written notice to the Board of Directors or the President or the Secretary. Such resignation shall take effect at the time specified therein; and unless otherwise specified therein, the acceptance of such resignation shall not be necessary to make it effective.

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(b) REMOVALS. Subject to any provisions of the Certificate of Incorporation, any Director or the entire Board of Directors may be removed with or without cause, at any meeting called for the purpose, by vote of the holders of a majority of the shares entitled to vote for the election of Directors, or a majority vote of the Board of Directors. This Section 8.1(b) may not be altered, amended or repealed except by the holders of a majority of the shares of stock issued and outstanding and entitled to vote for the election of the Directors.

(c) VACANCIES. Vacancies occurring in the office of Director and newly created Directorships resulting from any increase in the authorized number of Directors shall be filled by a majority of the Directors then in office, though less than a quorum, unless previously filled by the stockholders entitled to vote for the election of Directors, and the Directors so chosen shall hold office subject to the By-laws until the next annual meeting of Stockholders at which the term of office of the class to which they have been elected expires and until their successors are duly elected and qualify or until their earlier resignation or removal. If there are no Directors in office, then an election of Directors may be held in the manner provided by statute.

SECTION 8.2 OFFICERS. Any officer may resign at any time by giving written notice to the Board of Directors or the President or the Secretary. Such resignation shall take effect at the time specified therein; and unless otherwise specified therein, the acceptance of such resignation shall not be necessary to make it effective. The Board of Directors may, at any meeting called for the purpose, by vote of a majority of their entire number, remove from office any officer of the Corporation or any member of a committee, with or without cause. Any vacancy occurring in the office of President, Secretary or Treasurer shall be filled by the Board of Directors and the

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officers so chosen shall hold office subject to the By-laws for the unexpired term in respect of which the vacancy occurred and until their successors shall be elected and qualify or until their earlier resignation or removal.

ARTICLE 9

CERTIFICATE OF STOCK

SECTION 9.1 ISSUANCE OF STOCK. The Directors may, at any time and from time to time, if all of the shares of capital stock which the Corporation is authorized by its Certificate of Incorporation to issue have not been issued, subscribed for, or otherwise committed to be issued, issue or take subscriptions for additional shares of its capital stock up to the amount authorized in its Certificate of Incorporation. Such stock shall be issued and the consideration paid therefor in the manner prescribed by law.

SECTION 9.2 RIGHT TO CERTIFICATE; FORM. Every holder of stock in the Corporation shall be entitled to have a certificate, signed by, or in the name of the Corporation by, the Chairman of the Board, the President or a Vice President and the Treasurer or an Assistant Treasurer, or the Secretary or an Assistant Secretary of the Corporation, certifying the number of shares owned by him in the Corporation; provided that the Directors may provide by one or more resolutions that some or all of any or all classes or series of the Corporation's stock shall be uncertified shares. Certificates may be issued for partly paid shares and in such case upon the face or back of the certificates issued to represent any such partly paid shares, the total amount of the consideration to be paid therefor, and the amount paid thereon shall be specified.

SECTION 9.3 FACSIMILE SIGNATURE. Any of or all the signatures on the certificate may be facsimile. In case any officer, transfer agent or registrar who has signed or whose facsimile

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signature has been placed upon a certificate shall have ceased to be such officer, transfer agent or registrar before such certificate is issued, it may be issued by the Corporation with the same effect as if he were such officer, transfer agent or registrar at the date of issue.

SECTION 9.4 LOST CERTIFICATES. The Board of Directors may direct a new certificate or certificates to be issued in place of any certificate or certificates theretofore issued by the Corporation alleged to have been lost, stolen or destroyed, upon the making of an affidavit of that fact by the person claiming the certificate of stock to be lost, stolen or destroyed. When authorizing such issue of a new certificate or certificates, the Board of Directors may, in its discretion and as a condition precedent to the issuance thereof, require the owner of such lost, stolen or destroyed certificate or certificates, or his legal representative, to advertise the same in such manner as it shall require and/or to give the Corporation a bond in such sum as it may direct as indemnity against any claim that may be made against the Corporation with respect to the certificate alleged to have been lost, stolen or destroyed.

SECTION 9.5 TRANSFER OF STOCK. Upon surrender to the Corporation or the transfer agent of the Corporation of a certificate for shares duly endorsed or accompanied by proper evidence of succession, assignation or authority to transfer, it shall be the duty of the Corporation to issue a new certificate to the person entitled thereto, cancel the old certificate and record the transaction upon its books.

SECTION 9.6 REGISTERED STOCKHOLDERS. The Corporation shall be entitled to recognize the exclusive right of a person registered on its books as the owner of shares to receive dividends, and to vote as such owner, and to hold liable for calls and assessments a person registered on its books as the owner of shares, and shall not be bound to recognize any equitable or other claim to

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or interest in such share or shares on the part of any other person, whether or not it shall have express or other notice thereof, except as otherwise provided by the laws of Delaware.

ARTICLE 10

INDEMNIFICATION

SECTION 10.1 THIRD PARTY ACTIONS. The Corporation shall indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the Corporation) by reason of the fact that he is or was a Director, officer, employee or agent of the Corporation, or is or was serving at the request of the Corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorney's fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by him in connection with such action, suit or proceeding if he acted in good faith and in a manner he reasonably believed to be in or not opposed to the best interests of the Corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe his conduct was unlawful. The termination of any action, suit or proceeding by judgment, order, settlement, conviction, or upon plea of nolo contendere or its equivalent, shall not, of itself, create a presumption that the person did not act in good faith and in a manner which he reasonably believed to be in or not opposed to the best interests of the Corporation, and, with respect to any criminal action or proceeding, had reasonable cause to believe that his conduct was unlawful.

SECTION 10.2 DERIVATIVE ACTIONS. The Corporation shall indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action or

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suit by or in the right of the Corporation to procure a judgment in its favor by reason of the fact that he is or was a Director, officer, employee or agent of the Corporation, or is or was serving at the request of the Corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise against expenses (including attorneys' fees) actually and reasonably incurred by him in connection with the defense or settlement of such action or suit if he acted in good faith and in a manner he reasonably believed to be in or not opposed to the best interests of the Corporation and except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable for negligence or misconduct in the performance of his duty to the Corporation unless and only to the extent that the Court of Chancery or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper.

SECTION 10.3 EXPENSES. To the extent that a Director, officer, employee or agent of the Corporation has been successful on the merits or otherwise in defense of any action, suit or proceeding referred to in Sections 10.1 and 10.2, or in defense of any claim, issue or matter therein, he shall be indemnified against expenses (including attorneys' fees) actually and reasonably incurred by him in connection therewith.

SECTION 10.4 AUTHORIZATION. Any indemnification under Sections 10.1 and
10.2 (unless ordered by a court) shall be made by the Corporation only as authorized in the specific case upon a determination that indemnification of the Director, officer, employee or agent is proper in the circumstances because he has met the applicable standard of conduct set forth in Sections 10.1

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and 10.2. Such determination shall be made (a) by the Board of Directors by a majority vote of a quorum consisting of Directors who were not parties to such action, suit or proceeding, or (b) if such a quorum is not obtainable, or, even if obtainable a quorum of disinterested Directors so directs, by independent legal counsel in a written opinion, or (c) by the stockholders.

SECTION 10.5 ADVANCE PAYMENT OF EXPENSES. Expenses incurred by an officer or Director in defending a civil or criminal action, suit or proceeding may be paid by the Corporation in advance of the final disposition of such action, suit or proceeding as authorized by the Board of Directors in the specific case upon receipt of an undertaking by or on behalf of such officer or Director to repay such amount unless it shall ultimately be determined that he is entitled to be indemnified by the Corporation as authorized in this Article 10. Such expenses incurred by other employees and agents may be so paid upon such terms and conditions, if any, as the Board of Directors deems appropriate.

SECTION 10.6 NON-EXCLUSIVENESS. The indemnification provided by this Article 10 shall not be deemed exclusive of any other rights to which those seeking indemnification may be entitled under any by-law, agreement, vote of stockholders or disinterested Directors or otherwise, both as to action in his official capacity and as to action in another capacity while holding such office, and shall continue as to a person who has ceased to be a Director, officer, employee or agent and shall inure to the benefit of the heirs, executors and administrators of such a person.

SECTION 10.7 INSURANCE. The Corporation shall have power to purchase and maintain insurance on behalf of any person who is or was a Director, officer, employee or agent of the Corporation, or is or was serving at the request of the Corporation as a director, officer,

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employee or agent of another corporation, partnership, joint venture, trust or other enterprise against any liability asserted against him and incurred by him in any such capacity, or arising out of his status as such, whether or not the Corporation would have the power to indemnify him against such liability under the provisions of this Article 10.

SECTION 10.8 CONSTITUENT CORPORATIONS. The Corporation shall have power to indemnify any person who is or was a director, officer, employee or agent of a constituent corporation absorbed in a consolidation or merger with this Corporation or is or was serving at the request of such constituent corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, in the same manner as hereinabove provided for any person who is or was a Director, officer, employee or agent of the Corporation, or is or was serving at the request of the Corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise.

SECTION 10.9 ADDITIONAL INDEMNIFICATION. In addition to the foregoing provisions of this Article 10, the Corporation shall have the power, to the full extent provided by law, to indemnify any person for any act or omission of such person against all loss, cost, damage and expense (including attorney's fees) if such person is determined (in the manner prescribed in Section 10.4 hereof) to have acted in good faith and in a manner he reasonably believed to be in, or not opposed to, the best interest of the Corporation.

ARTICLE 11

EXECUTION OF PAPERS

Except as otherwise provided in these By-laws or as the Board of Directors may generally or in particular cases otherwise determine, all deeds, leases, transfers, contracts, bonds, notes,

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checks, drafts and other instruments authorized to be executed on behalf of the Corporation shall be executed by the President or the Treasurer.

ARTICLE 12

FISCAL YEAR

The fiscal year of the Corporation shall be fixed by resolution of the Board of Directors.

ARTICLE 13

SEAL

The Corporate seal shall have inscribed thereon the name of the Corporation, the year of its organization and the word "Delaware". The seal may be used by causing it or a facsimile thereof to be impressed or affixed or reproduced or otherwise.

ARTICLE 14

OFFICES

In addition to its principal office, the Corporation may have offices at such other places both within and without the State of Delaware as the Board of Directors may from time to time determine or the business of the Corporation may require.

ARTICLE 15

AMENDMENTS

Except as otherwise provided herein, these By-laws may be altered, amended or repealed or new By-laws may be adopted by the stockholders or by the Board of Directors, when such power is conferred upon the Board of Directors by the Certificate of Incorporation, at any regular meeting of the stockholders or of the Board of Directors, or at any special meeting of the stockholders or of the Board of Directors if notice of such alteration, amendment, repeal or adoption of new By-laws is contained in the notice of such special meeting, or by the written

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consent of a majority in interest of the outstanding voting stock of the Corporation or by the unanimous written consent of the Directors. If the power to adopt, amend or repeal by-laws is conferred upon the Board of Directors by the Certificate of Incorporation, it shall not divest or limit the power of the stockholders to adopt, amend or repeal by-laws.

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Exhibit 10.1

BRUKER DALTONICS INC.
2000 STOCK OPTION PLAN

1. PURPOSE OF THE PLAN.

This stock option plan (the "2000 Stock Option Plan") is intended to encourage ownership of the stock of Bruker Daltonics Inc. (the "Company") by management, employees, directors, consultants and advisors ("Optionees") of the Company and its subsidiaries, to induce qualified personnel to enter and remain in the employ of the Company or its subsidiaries and otherwise to provide additional incentive for Optionees to promote the success of its business.

2. STOCK SUBJECT TO THE 2000 STOCK OPTION PLAN.

(a) The total number of shares of the authorized but unissued or Treasury shares of the common stock, $.01 par value, of the Company ("Common Stock") for which options may be granted under the 2000 Stock Option Plan shall not exceed two million two hundred twenty thousand (2,220,000) shares, corresponding to four percent (4%) of the issued and outstanding shares of Common Stock after the completion of the Company's initial public offering, subject to adjustment as provided in Section 12 hereof.

(b) If an option granted hereunder shall expire or terminate for any reason without having vested fully or having been exercised in full, the unvested and/or unpurchased shares subject thereto shall again be available for subsequent option grants under the 2000 Stock Option Plan.

(c) Stock issuable upon exercise of an option granted under the 2000 Stock Option Plan may be subject to such restrictions on transfer, repurchase rights (but not to exceed 20% of the stock issuable upon exercise of options granted under the 2000 Stock Option Plan) or other restrictions as shall be determined by the Board of Directors of the Company (the "Board").

(d) Notwithstanding any other provision of this Plan to the contrary, the Committee shall have the right, in its sole discretion, to allocate and grant up to twenty percent (20%) of the Common Stock authorized to be granted as options hereunder as restricted stock to employees of


the Company on such terms and conditions and pursuant to such restricted stock agreements as the Committee, in its discretion, shall deem appropriate.

3. ADMINISTRATION OF THE 2000 STOCK OPTION PLAN.

At the discretion of the Board, the 2000 Stock Option Plan shall be administered either by (i) the Board, or (ii) the compensation committee (the "Compensation Committee") consisting of two or more members of the Board. In the event the Board is the administrator of the 2000 Stock Option Plan, references herein to the Compensation Committee shall be deemed to include the full Board. The Board may from time to time appoint a member or members of the Compensation Committee in substitution for or in addition to the member or members then in office and may fill vacancies on the Compensation Committee however caused. The Compensation Committee shall choose one of its members as Chairman and shall hold meetings at such times and places as it shall deem advisable. A majority of the members of the Compensation Committee shall constitute a quorum and any action may be taken by a majority of those present and voting at any meeting.

Any action may also be taken without the necessity of a meeting by a written instrument signed by a majority of the Compensation Committee. The decision of the Compensation Committee as to all questions of interpretation and application of the 2000 Stock Option Plan shall be final, binding and conclusive on all persons. The Compensation Committee shall have the authority to adopt, amend and rescind such rules and regulations as, in its opinion, may be advisable in the administration of the 2000 Stock Option Plan. The Compensation Committee may correct any defect or supply any omission or reconcile any inconsistency in the 2000 Stock Option Plan or in any option agreement granted hereunder in the manner and to the extent it shall deem expedient to carry the 2000 Stock Option Plan into effect and shall be the sole and final judge of such expediency. No Compensation Committee member shall be liable for any action or determination made in good faith.

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4. TYPE OF OPTIONS.

Options granted pursuant to the 2000 Stock Option Plan shall be authorized by action of the Compensation Committee and may be designated as either incentive stock options meeting the requirements of Section 422 of the Internal Revenue Code of 1986, as amended (the "Code"), or non-qualified options which are not intended to meet the requirements of such Section 422 of the Code, the designation to be in the sole discretion of the Compensation Committee. The 2000 Stock Option Plan shall be administered by the Compensation Committee in such manner as to permit options granted as incentive stock options to qualify as incentive stock options under the Code.

5. ELIGIBILITY

(a) As required by U.S. law, incentive stock options shall only be granted to Optionees who are employees. As a result, options designated as incentive stock options shall, subject to the limitation on amounts of more than 10% of the combined voting power of the Company as designated in Section
5(e), be granted only to employees (including officers and directors who are also employees) of the Company or any of its subsidiaries, including subsidiaries which become such after adoption of the 2000 Stock Option Plan.

(b) The law permits more flexibility for the grant of non-qualified stock options. Accordingly, options designated as non-qualified options may be granted to officers, employees, consultants, advisors and directors of the Company or of any of its subsidiaries, including subsidiaries which become such after adoption of the 2000 Stock Option Plan.

(c) As used herein, "subsidiary" or "subsidiaries" shall be as defined in Section 424 of the Code and the Treasury Regulations promulgated thereunder (the "Regulations").

(d) The Compensation Committee shall, from time to time, at its sole discretion, select from such eligible persons those to whom options shall be granted and shall determine the number of shares to be subject to each option. In determining the eligibility of a person to be granted an option, as well as in determining the number of shares to be granted to

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any person, the Compensation Committee in its sole discretion shall take into account the position and responsibilities of the person being considered, the nature and value to the Company or its subsidiaries of his or her service and accomplishments, his or her present and potential contribution to the success of the Company or its subsidiaries, and such other factors as the Compensation Committee may deem relevant.

(e) As required by law, no option designated as an incentive stock option shall be granted to any employee of the Company or any subsidiary if such employee owns, immediately prior to the grant of an option, stock possessing more than 10% of the total combined voting power of all classes of stock of the Company or of a parent or a subsidiary, unless the purchase price for the stock under such option shall be at least 110% of its fair market value at the time such option is granted and the option, by its terms, shall not be exercisable more than five years from the date it is granted. In determining the stock ownership under this paragraph, the provisions of Section 424(d) of the Code shall be controlling.

(f) In determining the fair market value under this paragraph, the provisions of Section 7 hereof shall apply.

6. OPTION AGREEMENT.

Each option shall be evidenced by an option agreement (the "Agreement") duly executed on behalf of the Company and by the Optionee to whom such option is granted, which Agreement shall comply with and be subject to the terms and conditions of the 2000 Stock Option Plan. The Agreement may contain such other terms, provisions and conditions which are not inconsistent with the 2000 Stock Option Plan as may be determined by the Compensation Committee; provided that (a) options designated as incentive stock options shall meet all of the conditions for incentive stock options as defined in Section 422 of the Code; (b) the vesting schedule contained in the form of incentive stock option agreement approved by the Board shall not be altered by the Compensation Committee for any grant of an incentive stock option; and (c) the vesting schedule contained in the form of non-qualified stock option agreement approved by the Board shall be the recommended vesting schedule for the grant of non-qualified stock options

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by the Compensation Committee but may be altered by the Compensation Committee. The date of grant of an option shall be as determined by the Compensation Committee. More than one option may be granted to an individual.

7. OPTION PRICE.

The option price or prices of shares of the Company's Common Stock for options designated as non-qualified stock options shall be as determined by the Compensation Committee, but in no event shall the option price of a non-qualified stock option be less than 50% of the fair market value of such Common Stock at the time the option is granted, as determined by the Compensation Committee. The option price or prices of shares of the Company's Common Stock for incentive stock options shall be not less than the fair market value of such Common Stock at the time the option is granted as determined by the Compensation Committee in accordance with the Regulations promulgated under
Section 422 of the Code. If such shares are then listed on any national securities exchange, the fair market value shall be the mean between the high and low sales prices, if any, on the largest such exchange on the date of the grant of the option or, if none, shall be determined by taking a weighted average of the means between the highest and lowest sales prices on the nearest date before and the nearest date after the date of grant in accordance with Treasury Regulations Section 25.2512-2. If the shares are not then listed on any such exchange, the fair market value of such shares shall be the mean between the high and low sales prices, if any, as reported in the National Association of Securities Dealers Automated Quotation National Market ("NASDAQ/NM") for the date of the grant of the option, or, if none, shall be determined by taking a weighted average of the means between the highest and lowest sales on the nearest date before and the nearest date after the date of grant in accordance with Treasury Regulations Section 25.2512-2. If the shares are not then either listed on any such exchange or quoted in NASDAQ/NM, the fair market value shall be the mean between the average of the "Bid" and the average of the "Ask" prices, if any, as reported in the National Daily Quotation Service for the date of the grant of the option, or, if none, shall be determined by taking a weighted average of the means between the highest and lowest sales

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prices on the nearest date before and the nearest date after the date of grant in accordance with Treasury Regulations Section 25.2512-2. If the fair market value cannot be determined under the preceding three sentences, it shall be determined in good faith by the Compensation Committee.

8. MANNER OF PAYMENT; MANNER OF EXERCISE.

(a) Options granted under the 2000 Stock Option Plan may provide for the payment of the exercise price, as determined by the Compensation Committee, and as set forth in the Option Agreement, by delivery of cash or a check payable to the order of the Company in an amount equal to the exercise price of such options.

(b) To the extent that the right to purchase shares under an option has accrued and is in effect, options may be exercised in full at one time or in part from time to time, by giving written notice, signed by the Optionee exercising the option, to the Company, stating the number of shares with respect to which the option is being exercised, accompanied by payment in full for such shares as provided in subparagraph (a) above. Upon such exercise, delivery of a certificate for paid-up non-assessable shares shall be made at the principal office of the Company to the Optionee exercising the option at such time, during ordinary business hours, not more than thirty (30) days from the date of receipt of the notice by the Company, as shall be designated in such notice, or at such time, place and manner as may be agreed upon by the Company and the person or persons exercising the option. Upon exercise of the option and payment as provided above, the Optionee shall become a shareholder of the Company as to the Shares acquired upon such exercise.

9. EXERCISE OF OPTIONS.

Each option granted under the 2000 Stock Option Plan shall, subject to
Section 6, Section 10(b) and Section 12 hereof, be exercisable at such time or times and during such period as determined by the Compensation Committee which shall be set forth in the Agreement; provided, however, that no option granted under the 2000 Stock Option Plan shall have a term in excess of ten (10) years from the date of grant.

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To the extent that an option to purchase shares is not exercised by an Optionee when it becomes initially exercisable, it shall not expire but shall be carried forward and shall be exercisable, on a cumulative basis, until the expiration of the exercise period. No partial exercise may be made for less than fifty (50) full shares of Common Stock.

Notwithstanding the foregoing, the Compensation Committee may in its discretion accelerate the exerciseability of any option subject to such terms and conditions as the Compensation Committee deems necessary and appropriate.

10. TERM OF OPTIONS; EXERCISEABILITY.
(a) TERM.

(1) Each option shall expire not more than ten (10) years from the date of the granting thereof, but shall be subject to earlier termination as herein provided.

(2) Except as otherwise provided in this Section 10, an option granted to any employee who ceases to be an employee of the Company, or an option granted to any other Optionee who ceases to have the same relationship with the Company or one of its subsidiaries which was in effect on the date the option was granted, shall terminate immediately on the date such Optionee ceases to be an employee, or ceases to have such relationship with the Company or one of its subsidiaries, or on the date on which the option expires by its terms, whichever occurs first.

(3) If such termination of employment or relationship is because the Optionee has become permanently disabled (within the meaning of
Section 22(e)(3) of the Code), such option shall terminate thirty (30) days after the date such Optionee ceases to be an employee or to have such relationship, or on the date on which the option expires by its terms, whichever occurs first.

(4) In the event of the death of any Optionee, any option granted to such Optionee shall terminate ninety (90) days after the date of death, or on the date on which the option expires by its terms, whichever occurs first.

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(5) Notwithstanding subparagraphs (2), (3) and (4) above, the Compensation Committee shall have the authority to extend the expiration date of any outstanding option in circumstances in which it deems such action to be appropriate, provided that no such extension shall extend the term of an option beyond the date on which the option would have expired if no termination of the Optionee's employment or relationship with the Company or its subsidiary had occurred.

(b) EXERCISEABILITY.

An option granted to an Optionee who ceases to be an employee, or ceases to have the same relationship with the Company or one of its subsidiaries which was in existence on the date the option was granted shall be exercisable only to the extent that the right to purchase shares under such option has accrued and is in effect on the date such Optionee ceases to be an employee, or ceases to have such relationship with the Company or one of its subsidiaries.

11. OPTIONS NOT TRANSFERABLE.

The right of any Optionee to exercise any option granted to him or her shall not be assignable or transferable by such Optionee otherwise than by will or the laws of descent and distribution, and any such option shall be exercisable during the lifetime of such Optionee only by him or her. Any option granted under the 2000 Stock Option Plan shall be null and void and without effect upon the bankruptcy of the Optionee to whom the option is granted, or upon any attempted assignment or transfer, except as herein provided, including without limitation any purported assignment, whether voluntary or by operation of law, pledge, hypothecation or other disposition, attachment, divorce, trustee process or similar process, whether legal or equitable, upon such option.

12. RECAPITALIZATIONS, REORGANIZATIONS AND THE LIKE.

(a) In the event that the outstanding shares of the Common Stock of the Company are changed into or exchanged for a different number or kind of shares or other securities of the Company or of another corporation by reason of any reorganization, merger, consolidation,

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recapitalization, reclassification, stock split-up, combination of shares, or dividends payable in capital stock, appropriate adjustment shall be made in the number and kind of shares as to which options may be granted under the 2000 Stock Option Plan and as to which outstanding options or portions thereof then unexercised shall be exercisable, to the end that the proportionate interest of the Optionee shall be maintained as before the occurrence of such event; such adjustment in outstanding options shall be made without change in the total price applicable to the unexercised portion of such options and with a corresponding adjustment in the option price per share.

(b) In addition, unless otherwise determined by the Board in its sole discretion, in the case of any (i) sale or conveyance to another entity of all or substantially all of the property and assets of the Company, including, without limitation, by way of merger or consolidation, or (ii) Change in Control (as hereinafter defined) of the Company, the purchaser(s) of the Company's assets or stock may, in his, her or its discretion, deliver to the Optionee the same kind of consideration that is delivered to the shareholders of the Company as a result of such sale, conveyance or Change in Control, or the Board may cancel all outstanding options in exchange for consideration in cash or in kind which consideration in both cases shall be equal in value to the value of those shares of stock or other securities the Optionee would have received had the option been exercised (to the extent then exercisable) and no disposition of the shares acquired upon such exercise been made prior to such sale, conveyance or Change in Control, less the option price therefor. Upon receipt of such consideration by the Optionee, his or her option shall immediately terminate and be of no further force and effect. The value of the stock or other securities the Optionee would have received if the option had been exercised shall be determined in good faith by the Board, and in the case of shares of the Common Stock of the Company, in accordance with the provisions of Section 7 hereof. The Board shall also have the power and right to accelerate the exerciseability of any options, notwithstanding any limitations in this 2000 Stock Option Plan or in the Agreement upon such a sale, conveyance or Change in Control. Upon such acceleration, any options or portion thereof originally designated as incentive stock options that no longer qualify as incentive stock options under Section 422 of the Code as a

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result of such acceleration shall be redesignated as non-qualified stock options. A "Change in Control" shall be deemed to have occurred if any person, or any two or more persons acting as a group, and all affiliates of such person or persons, who prior to such time owned less than twenty percent (20%) of the then outstanding Common Stock of the Company, shall acquire, whether by purchase, exchange, tender offer, merger, consolidation or otherwise, such additional shares of the Company's Common Stock in one or more transactions, or series of transactions, such that following such transaction or transactions, such person or group and affiliates beneficially own at least fifty percent (50%) of the Company's Common Stock outstanding.

(c) Upon dissolution or liquidation of the Company, all options granted under this 2000 Stock Option Plan shall terminate, but each Optionee (if at such time in the employ of or otherwise associated with the Company or any of its subsidiaries) shall have the right, immediately prior to such dissolution or liquidation, to exercise his or her option to the extent then exercisable.

(d) No fraction of a share shall be purchasable or deliverable upon the exercise of any option, but in the event any adjustment hereunder of the number of shares covered by the option shall cause such number to include a fraction of a share, such fraction shall be adjusted to the nearest smaller whole number of shares.

13. NO SPECIAL EMPLOYMENT OR OTHER RIGHTS.

Nothing contained in the 2000 Stock Option Plan or in any option granted under the Plan shall confer upon any Optionee right with respect to the continuation of his or her employment or other relationship by the Company (or any subsidiary) or interfere in any way with the right of the Company (or any subsidiary), subject to the terms of any separate employment or other agreement, at any time to terminate such employment or other relationship or to increase or decrease the compensation of the option holder from the rate in existence at the time of the grant of an option. Whether an authorized leave of absence, or absence in military or government service, shall constitute termination of employment or another relationship shall be determined by the Compensation Committee at the time.

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14. WITHHOLDING.

The Company's obligation to deliver shares upon the exercise of any option granted under the 2000 Stock Option Plan and any payments or transfers under Section 12 hereof shall be subject to the Optionee's satisfaction of all applicable Federal, state and local income, excise, employment and any other tax withholding requirements. All non-U.S. Optionees must pay all applicable employee and employers wage and other withholding taxes in advance of receiving shares upon exercise of any vested option.

15. RESTRICTIONS ON ISSUE OF SHARES.

(a) Notwithstanding the provisions of Section 8, the Company may delay the issuance of shares covered by the exercise of an option and the delivery of a certificate for such shares until one of the following conditions shall be satisfied:

(i) The shares with respect to which such option has been exercised are at the time of the issue of such shares effectively registered or qualified under applicable Federal and state securities acts now in force or as hereafter amended; or

(ii) Counsel for the Company shall have given an opinion, which opinion shall not be unreasonably conditioned or withheld, that such shares are exempt from registration and qualification under applicable Federal and state securities acts now in force or as hereafter amended.

(b) It is intended that all exercises of options shall be effective, and the Company shall use its best efforts to bring about compliance with the above conditions within a reasonable time, except that the Company shall be under no obligation to qualify shares or to cause a registration statement or a post-effective amendment to any registration statement to be prepared for the purpose of covering the issue of shares in respect of which any option may be exercised, except as otherwise agreed to by the Company in writing.

16. PURCHASE FOR INVESTMENT; RIGHTS OF HOLDER ON SUBSEQUENT REGISTRATION.

Unless the shares to be issued upon exercise of an option granted under the 2000 Stock Option Plan have been effectively registered under the Securities Act of 1933, as now in force or

11

hereafter amended, the Company shall be under no obligation to issue any shares covered by any option unless the Optionee, in whole or in part, shall give a written representation and undertaking to the Company which is satisfactory in form and scope to counsel for the Company and upon which, in the opinion of such counsel, the Company may reasonably rely, that he or she is acquiring the shares issued pursuant to such exercise of the option for his or her own account as an investment and not with a view to, or for sale in connection with, the distribution of any such shares, and that he or she will make no transfer of the same except in compliance with any rules and regulations in force at the time of such transfer under the Securities Act of 1933, or any other applicable law, and that if shares are issued without such registration, a legend to this effect may be endorsed upon the securities so issued. In the event that the Company shall, nevertheless, deem it necessary or desirable to register under the Securities Act of 1933 or other applicable statutes any shares with respect to which an option shall have been exercised, or to qualify any such shares for exemption from the Securities Act of 1933 or other applicable statutes, then the Company may take such action and may require from each Optionee such information in writing for use in any registration statement, supplementary registration statement, prospectus, preliminary prospectus or offering circular as is reasonably necessary for such purpose and may require reasonable indemnity to the Company and its officers and directors and controlling persons from such holder against all losses, claims, damages and liabilities arising from such use of the information so furnished and caused by any untrue statement of any material fact therein or caused by the omission to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances under which they were made.

17. MODIFICATION OF OUTSTANDING OPTIONS.

The Board may authorize the amendment of any outstanding option with the consent of the Optionee when and subject to such conditions as are deemed to be in the best interests of the Company and in accordance with the purposes of this 2000 Stock Option Plan.

12

18. APPROVAL OF STOCKHOLDERS.

The 2000 Stock Option Plan shall be subject to approval by the vote of stockholders holding at least a majority of the voting stock of the Company present, or represented, and entitled to vote at a duly held stockholders' meeting, or by written consent of the stockholders as provided for under applicable state law, within twelve (12) months after the adoption of the 2000 Stock Option Plan by the Board of Directors and shall take effect as of the date of adoption by the Board of Directors upon such approval. The Compensation Committee may grant options under the 2000 Stock Option Plan prior to such approval, but any such option shall become effective as of the date of grant only upon such approval and, accordingly, no such option may be exercisable prior to such approval.

19. TERMINATION AND AMENDMENT.

Unless sooner terminated as herein provided, the 2000 Stock Option Plan shall terminate ten (10) years from the date upon which the 2000 Stock Option Plan was duly adopted by the Board. The Board may at any time terminate the 2000 Stock Option Plan or make such modification or amendment thereof as it deems advisable; provided, however, that except as provided in this Section 20, the Board may not, without the approval of the stockholders of the Company obtained in the manner stated in Section 19, increase the maximum number of shares for which options may be granted or change the designation of the class of persons eligible to receive options under the 2000 Stock Option Plan, or make any other change in the 2000 Stock Option Plan which requires stockholder approval under applicable law or regulations.

20. RESERVATION OF STOCK.

The Company shall at all times during the term of the 2000 Stock Option Plan reserve and keep available such number of shares of stock as will be sufficient to satisfy the requirements of the 2000 Stock Option Plan and shall pay all fees and expenses necessarily incurred by the Company in connection therewith.

13

21. LIMITATION OF RIGHTS IN THE OPTION SHARES.

An Optionee shall not be deemed for any purpose to be a stockholder of the Company with respect to any of the options except to the extent that the option shall have been exercised with respect thereto and, in addition, a certificate shall have been issued theretofore and delivered to the Optionee.

22. NOTICES.

Any communication or notice required or permitted to be given under the 2000 Stock Option Plan shall be in writing, and mailed by registered or certified mail or delivered by hand, if to the Company, to its principal place of business, attention: Treasurer, and, if to an Optionee, to the address as appearing on the records of the Company.

14

Exhibit 10.2

SHARING AGREEMENT

This Agreement made and entered into as of the 28th day of February, 2000, (the "Date of the Agreement"), and as amended on April 7, 2000, by and among

o Bruker Physik AG ("BPAG-DE"), a German corporation,

o Techneon AG ("TAG-CH"), a Swiss corporation,

o Bruker Analytik GmbH ("BA-DE"), a German corporation,

o Bruker Elektronik GmbH ("BE-DE"), a German corporation,

o SBI Holding AG ("SBI-CH"), a Swiss corporation,

o Bruker Instruments, Inc. ("BII-US"), a Massachusetts corporation,

o Rhena Invest AG ("RIAG-CH"), a Swiss corporation,

o Bruker AG ("B-CH"), a Swiss corporation,

o Bruker-Spectrospin SA ("BS-FR"), a French corporation,

o Bruker SA("B-FR"), a French corporation,

o Bruker Daltonics Inc. ("BDAL-US"), a Delaware corporation,

o Bruker Optics, Inc. ("BOPT-US"), a Massachusetts corporation,

o Bruker AXS Inc. ("BAXS-US"), a Delaware corporation, and

o Bruker Medical AG ("BMED-CH"), a Swiss corporation.

WITNESSETH:

WHEREAS, the parties hereto presently are all affiliates of each other;

WHEREAS, each party hereto uses certain names, trademarks and other intellectual property owned by other of the parties hereto and may use certain services, facilities, products and related items of other of the parties hereto; and


WHEREAS, the parties hereto desire to confirm by a written agreement the arm's-length terms and conditions under which all such use has taken place and shall take place in the future;

NOW, THEREFORE, in consideration of the foregoing and the mutual covenants contained herein, the parties hereto hereby agree as follows:

1.0 Definitions

1.1 "Affiliate" shall mean any person or entity which, directly or indirectly, controls a party hereto, or is controlled by a party hereto, it being understood that for such purposes "control" shall mean possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of such person or entity, whether through the ownership of voting securities or by contract or otherwise.

1.2 "Change of Control" shall mean, with respect to any party hereto, a change in the possession to a third party who is presently not an Affiliate, directly or indirectly, of the power to direct or cause the direction of the management of policies of such party, whether through a change in the ownership of voting securities or by contract or otherwise which occurs prior to completion of a public offering of at least $25,000,000 (twenty five million dollars) on a well-established public stock market (e.g. NASDAQ, Neuer Markt, or others). An initial public offering and transfer of control of a party to public ownership shall specifically not constitute a Change of Control.

1.3 "Intellectual Property" shall mean all patents, patent applications, inventions, trademarks, trademark applications, copyrights, copyright applications, trade secrets, common law rights and other intellectual property rights of any nature whatsoever in existence as of the Date of the Agreement, provided, however, that in the


case of any patents and patent applications of Bruker Daltonics, only those patents and patent applications listed on Attachment B shall be included in Intellectual Property.

1.4 "Lien" shall mean, with respect to any item, any mortgage, deed of trust, pledge, hypothecation, assignment, security interest, lien, charge, restriction, adverse claim by a third party, title defect or encumbrance of any kind.

1.5 The "Name" shall mean the name "Bruker", any logos associated therewith, and all Intellectual Property rights related thereto together with all goodwill associated therewith.

2.0 Name

2.1 The parties acknowledge that BA-DE owns the entire right, title and interest in and to the Name in Germany, as well as various international countries listed in Attachment A. The parties acknowledge that BPAG-DE owns the entire right, title and interest in and to the Name in the U.S., Israel and the rest of the world, except where the rights to the Name are specifically owned by BA-DE.

2.2 BA-DE and BPAG-DE hereby confirm that the other parties have properly used the Name prior to the date hereof.

2.3 BA-DE and BPAG-DE hereby grant the other parties hereto a perpetual, irrevocable, non-exclusive, royalty-free, non-transferable right and license to use the Name in connection with the conduct and operation of the business, as the same may be conducted from time to time, of each such party, subject to and in accordance with the following:

2.3.1 Each party shall use the Name in such a manner that it does not interfere with any other party's use of the Name. Moreover, all parties hereto have or will endeavour to adopt additional names in conjunction with the Name Bruker to


identify clearly the scope and purpose of each autonomous business (e.g. Bruker Optics, Bruker Daltonics(R), Bruker AXS, Bruker Medical, etc.)

2.3.2 No party shall at any time, directly or indirectly, take any material action which materially detracts from the goodwill associated with the Name.

2.3.3 Notwithstanding the irrevocable, perpetual nature of the license set forth in this Section 2.3, for ten (10) years after the signing of this Agreement, a Party's license under this Section 2.3 may become null and void at the option of BPAG-DE and BA-DE, which option must be exercised in writing within ninety (90) days of the occurrence if a party (a) files a voluntary petition for bankruptcy, (b) has an involuntary petition for bankruptcy filed against it which remains undismissed for at least sixty (60) consecutive days, (c) fails to comply with the provisions of this Section 2.3,
(d) suffers a major loss of its reputation in its industry or marketplace, such as by the distribution of defective, harmful, illegal, or dangerous goods or merchandise which materially detracts from the goodwill associated with the Name, or (e) undergoes a Change of Control. Provided, however, that each party hereto which may receive such written notice under this section, shall be given a ninety (90) day period after receipt of written notice to cure the problem or occurrence which led to the notice.

2.3.4 While the license set forth in this Section 2.3 is non-transferable, a party shall have the right to have its Affiliates use the Name subject to and in accordance with the following:

2.3.4.1 Use by an Affiliate shall be subject to all the conditions of this Section 2.3.


2.3.4.2 The party to this Agreement which permits its Affiliate to use the Name shall be fully responsible under this Agreement for the use of the Name by such Affiliate.

2.3.5 No party shall take any action which would cause a Lien to be placed on the Name or on a party's license rights under this Section 2.3.

2.4 In the event a party at any time believes a person or entity not a party to this Agreement is infringing the Name or in the event any party's use of the Name at any time leads to a claim that it is infringing the rights of a third party, the parties hereto will work together and cooperate in good faith with respect to the handling of such matter. The financial burden of enforcing the rights in the Name will be shared equitably between the parties hereto.

3.0 Technology

3.1 The parties acknowledge that each party hereto (a) owns various technology and the Intellectual Property relating thereto, and (b) has used and uses the technology and Intellectual Property of other parties hereto, provided, however, that use of the patents and patent applications included in such Intellectual Property by each party hereto (other than use pursuant to the separate written agreements referred to in Section 3.3 below) is limited to use of these patents and patent applications as it is in effect prior to the Date of the Agreement, and (c) that the Bruker Daltonics patents and patent applications described in Schedule B are used only by those parties specified as using such patents and patent applications in such Schedule B.

3.2 Each party confirms that the other parties hereto have properly used its technology and related Intellectual Property prior to the date hereof.


3.3 Each party acknowledges that certain specific written agreements are in place between certain parties hereto defining the use, royalties and terms and conditions of use of technology and related intellectual property between the specific parties to such separate previously existing written agreements. This Agreement shall not supersede or replace any existing written agreements pertaining to the subject matter hereof. For all technology and related intellectual property which is not governed by a specific separate written agreement between the parties or between any one or more parties and a third party, each party hereby grants each of the other parties hereto a perpetual, irrevocable, non-exclusive, royalty free, non-transferable right and license to use the technology and related Intellectual Property of the granting party in connection with the conduct and operation of the business, as the same may be conducted from time to time, of each such other party, unless such other party hereto undergoes a Change of Control, subject to and in accordance with the following:

3.3.1 In the event a party (the "First Party") desires to make a broader use of the technology or Intellectual Property of another party (the "Second Party") hereto than the use of such Intellectual Property by the First Party as of the Date of this Agreement, the two parties shall negotiate in good faith regarding the possibility of entering into a written agreement permitting the First Party to make such broader use, on arm's length terms and conditions such as would be utilized in a typical transaction with a person or entity not a party to this Agreement, provided, however, that neither the First Party nor the Second Party shall have any obligation to enter into any such agreement.

3.3.2 No party (the "First Party") shall at any time take any


action which would materially adversely affect the value of any technology or Intellectual Property of any other party hereto, which has been made available to the First Party hereunder.

3.3.3 Each party shall use the technology and Intellectual Property of the other parties in such a manner that it does not materially interfere with any other party's use thereof.

3.3.4 While the license set forth in this Section 3.3 is non-transferable, a party shall have the right to have its Affiliates use the technology or Intellectual Party of another party hereto subject to and in accordance with the following:

3.3.4.1 Use by an Affiliate shall be subject to all of the conditions of this Section 3.3.

3.3.4.2 The party to this Agreement which permits its Affiliate to use the technology or Intellectual Property of another party shall be fully responsible for the use thereof by such Affiliate.

3.3.5 No party shall take any action which shall cause a Lien to be placed on the technology or Intellectual Property of another party hereto or on such party's license rights under this Section 3.3.

3.4 In the event a party at any time believes a person or entity not a party to this Agreement is infringing the technology or Intellectual Property of any party to this Agreement or in the event any party's use of the technology or Intellectual Property of a party to this Agreement at any time leads to a claim that such using party is infringing the rights of a third party, the party which owns such technology or Intellectual Property will be responsible for the handling of such matter, provided that such owning


party shall receive reasonable cooperation in connection therewith from the other parties hereto which use such technology or Intellectual Property.

4.0 Distribution

4.1 The parties acknowledge that prior to the date hereof they have used, and may continue to use after the date hereof, selected common distribution channels for their respective products, including through the Affiliates of the parties hereto.

4.2 Such common distribution channels shall continue, and no party shall take any action which would interfere with the right of any other party hereto to use such distribution channels.

4.3 The terms and conditions of sale and the transfer pricing for such distribution will be on an arm's length basis as would be utilized in a typical transaction with a person or entity not a party to this Agreement.

4.4 No common sales channel shall have any exclusivity in any country or other geographic area and any party hereto shall have the right to establish its own subsidiary sales channel or third-party sales channels in any country or other geographic area at any time for any reason. However, in this case sixty (60) days written notice shall be given.

4.5 In addition to the ability to establish a new sales channel as described in Section 4.4 hereof, a party hereto shall have the right at any time to establish additional exclusive or non-exclusive sales channels in any country, geographic area or market segment with sixty (60) days written notice.

5.0 Shared Services


Any subleases of facilities, sharing of employees, shared services such as payroll services and any related matters may occur as two (2) or more of the parties hereto may agree from time to time as evidenced by a written agreement containing arm's length terms, conditions and pricing.

6.0 Components and Subunits

To the extent that prior to the date hereof a party has purchased subunits or components from another party hereto, such purchases may occur after the date hereof subject to and in accordance with the following:

6.1 Purchases may occur for seven (7) years after the date hereof, and spare parts purchases may occur for twelve (12) years after the date hereof.

6.2 The prices shall be the prices in effect as of the date hereof, provided that there may be a yearly price increase in an amount not to exceed the yearly increase in the Consumer Price Index, or corresponding index, of the country in which the manufacture occurs.

6.3 The terms and conditions shall be the previously established terms and conditions, provided that all such terms and conditions shall be reasonable arm's length terms and conditions. In any case, the prices shall be competitive, and from time to time may have to be adjusted by mutual agreement bases on cost and market conditions.

7.0 Miscellaneous Provisions

7.1 This Agreement shall be governed by and construed in accordance with either the laws of the Federal Republic of Germany or the laws of the Commonwealth of Massachusetts, USA. If a party (or parties) hereto has a complaint against another party (or parties) hereto, then the defendant shall have the choice of law and jurisdiction between Massachusetts and Germany.


7.2 All notices given hereunder shall be in writing and sent by certified mail, return receipt requested or by facsimile (receipt confirmed) to the principal place of business of each party hereto, provided that a party may change its address for notice in writing.

7.3 Subject to the prohibitions on transferability set forth herein, this Agreement shall be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns. To the extent set forth herein, this Agreement shall bind the Affiliates of the parties hereto.

7.4. The headings of the provisions of this Agreement have been inserted for convenience of reference only and shall not be deemed to be part of this Agreement.

7.5 This Agreement may be executed in any number of counterparts and by the different parties hereto in separate counterparts, each of which when so executed and delivered shall be an original, but all of which together shall constitute one and the same instrument, and it shall not be necessary in making proof of this Agreement to produce or account for more than one such counterpart. Facsimile signatures may be treated as original signatures.

7.6 In the event that any one or more of the provisions contained herein is held to be void or unenforceable for any reason, the validity or enforceability of the remainder of this Agreement shall continue in full force and effect, and such void or unenforceable provision shall be enforced to the maximum extent permissible.

7.7 This Agreement does not supersede any prior or contemporaneous written agreements in connection therewith. This Agreement may be amended or waived only by a written instrument executed by all parties hereto.


IN WITNESS WHEREOF, the parties hereto have executed this Agreement under seal in a series of counterpart originals as of the date first written above.

BRUKER PHYSIK AG                            BRUKER ANALYTIK GMBH

By:_______________________________          By:_______________________________
Title:____________________________          Title:____________________________

TECHNEON AG                                 BRUKER ELEKTRONIK GMBH

By:_______________________________          By:_______________________________
Title:____________________________          Title:____________________________

SBI Holding AG                              BRUKER INSTRUMENTS, INC.

By:_______________________________          By:_______________________________
Title:____________________________          Title:____________________________

RHENA INVEST AG                             BRUKER AG

By:_______________________________          By:_______________________________
Title:____________________________          Title:____________________________

BRUKER-SPECTROSPIN SA                       BRUKER SA

By:_______________________________          By:_______________________________
Title:____________________________          Title:____________________________

BRUKER DALTONICS INC.                       BRUKER OPTICS, INC.

By:_______________________________          By:_______________________________
Title:____________________________          Title:____________________________

BRUKER AXS INC.                             BRUKER MEDICAL AG

By:_______________________________          By:_______________________________
Title:____________________________          Title:____________________________


Attachment A

Country           Date of Filing    Present Owner             Number            Remarks
-------           --------------    -------------             ------            -------
Germany           10.21.71          Bruker Analytik GmbH      893509
Int'l Reg.        25.5.72           Bruker Analytik GmbH      388454            CH BE NL LU FR IT ES
                                                                                AT LI CS
Israel            31.5.72           Bruker Physik AG          35545
US                9.8.72            Bruker Physik AG          1133028           Includes Logo


Attachment B Ward and Olivo Status Report For Bruker Daltonics, Inc. As of 03/21/00

------------------------------------------------------------------------------------------------------------------------------
Application Title or     W&O Doc.      Application      Application   Assignee        Patent Number        Current Status
Project Description      No.           Serial Number    Filing Date                   Issue Date           of Application
                                                                                                           or Project
------------------------------------------------------------------------------------------------------------------------------
Extended Bradbury        140-011       08/548,012       10/5/95       Bruker          (see 140-023)        Re-filed as a
Nielson Gate                                                          Analytical                           continuation
                                                                      Instruments                          (see 140-023)
------------------------------------------------------------------------------------------------------------------------------
Multideflector           140-012       08/560,396       11/17/95      Bruker          5,696,375-12/9/97    Issued.
                                                                      Analytical                           Application for
                                                                      Instruments                          reissue pending
------------------------------------------------------------------------------------------------------------------------------
High Resolution Post     140-013       08/561,635       11/17/95      Bruker          5,753,909-5/19/98    Issued
Selector for Time of                                                  Analytical
Flight Mass                                                           Instruments
Spectrometry
------------------------------------------------------------------------------------------------------------------------------
Deflection Based         140-014       08/561,635       11/22/95      Bruker          5/,821,534-5/13/98   Issued
Daughter Ion Selector                                                 Analytical
                                                                      Instruments
------------------------------------------------------------------------------------------------------------------------------
Split Field Interface    140-015       08/561,634       11/22/95      Bruker          5,744,791-4/28/98    Issued
                                                                      Analytical
                                                                      Instruments
------------------------------------------------------------------------------------------------------------------------------
Metal Ion Directed       140-016       08/652,708       5/30/96       Bruker          N/A                  Pending.
Cleavage of Peptide                                                   Analytical                           Awaiting
Bonds                                                                 Instruments                          Instructions
                                                                                                           from the client
------------------------------------------------------------------------------------------------------------------------------
Nth Order Delayed        140-017       08/644,854       5/10/96       Bruker          5,861,623-1/19/99    Issued
Extraction                                                            Analytical
                                                                      Instruments
------------------------------------------------------------------------------------------------------------------------------
Gas Flow Focusing        140-018       N/A              N/A           Bruker          N/A                  Application
Based Ion Source                                                      Daltonics,                           draft provided
Application                                                           Inc.                                 to client, but
                                                                                                           no instructions
                                                                                                           to proceed - NO
                                                                                                           ACTION
------------------------------------------------------------------------------------------------------------------------------
Co-Axial Multiple        140-019A      08/866,134       5/30/97       Bruker          N/A                  Pending.
Reflection Time of                                                    Daltonics,                           Awaiting PTO
Flight Mass                                                           Inc.                                 response
Spectrometer
------------------------------------------------------------------------------------------------------------------------------
Shield Lens              140-021       08/926,541       9/10/97       Bruker          5,942,758-8/24/99    Issued
                                                                      Daltonics,
                                                                      Inc.
------------------------------------------------------------------------------------------------------------------------------
Extended Bradbury        140-023       08/911,639       8/15/97       Bruker          5,986,258-11/16/99   Issued
Nielson Gate                                                          Daltonics,
(Continuation of                                                      Inc.
140-011)
------------------------------------------------------------------------------------------------------------------------------
Kinetic Energy           140-026       09/032,510       2/27/98       Bruker          N/A                  Pending.
Focusing for Pulsed                                                   Daltonics,                           Awaiting PTO
Ion Desorption Mass                                                   Inc.                                 response
Spectroscopy
------------------------------------------------------------------------------------------------------------------------------


Ward and Olivo Status Report For Bruker Daltonics, Inc. As of 03/21/00

----------------------------------------------------------------------------------------------------------------------
Application Title or       W&O Doc.      Application    Application   Assignee       Patent        Current Status
Project Description        No.           Serial         Filing Date                  Number        of Application
                                         Number                                      Issue Date    or Project
----------------------------------------------------------------------------------------------------------------------
Increased MS/MS            140-028       N/A            N/A           Bruker         N/A           Invention
Sensitivity in Time of                                                Daltonics,                   Disclosure - NO
Flight Mass                                                           Inc.                         ACTION
Spectroscopy
----------------------------------------------------------------------------------------------------------------------
Surface Induced            140-029       09/087,535     5/29/98       Bruker         N/A           Pending.
Dissociation with                                                     Daltonics,                   Awaiting PTO
Pulsed Ion Extraction                                                 Inc.                         response.
----------------------------------------------------------------------------------------------------------------------
RF-DC Ion Guide            140-030       N/A            N/A           Bruker         N/A           Application
                                                                      Daltonics,                   Draft provided
                                                                      Inc.                         to client. To
                                                                                                   be finalized
                                                                                                   and filed ASAP
----------------------------------------------------------------------------------------------------------------------
Co-Axial Multiple          140-031       09/282,076     3/30/99       Bruker         N/A           Pending.
Reflection Time of                                                    Daltonics,                   Awaiting PTO
Flight Mass                                                           Inc.                         response.
Spectrometer (CIP of
140-019A)
----------------------------------------------------------------------------------------------------------------------
Multiple Ion Trap          140-032       N/A            N/A           Bruker         N/A           Application
Orthogonal Time of                                                    Daltonics,                   Draft provided
Flight Mass Spectrometer                                              Inc.                         to client. To
                                                                                                   be finalized
                                                                                                   and filed ASAP.
----------------------------------------------------------------------------------------------------------------------
"Multipart" Capillary      140-033       N/A            2/18/00       Bruker         N/A           Patent
for API Source                                                        Daltonics,                   Application
                                                                      Inc.                         filed. Awaiting
                                                                                                   PTO Response.
----------------------------------------------------------------------------------------------------------------------
Method and Apparatus       140-034       09/374,477     8/13/99       Bruker         N/A           Pending.
for Multiple Frequency                                                Daltonics,                   Missing parts
Multipole                                                             Inc.                         filed.
                                                                                                   Preliminary
                                                                                                   Amendment
                                                                                                   to be filed ASAP.
----------------------------------------------------------------------------------------------------------------------
Reissue Application re     140-035       09/324,098     6/1/99        Indiana        N/A           Pending.
Reilly et al. US Pat.                                                 Univ.                        Missing parts
No. 5,712,479                                                         Foundation                   filed 11/15/99.
----------------------------------------------------------------------------------------------------------------------
Ionization Chamber for     140-036       09/263,659     3/5/99        Bruker         N/A           Pending.
Atmospheric Pressure                                                  Daltonics,                   Missing parts
Ionization Mass                                                       Inc.                         filed.
Spectroscopy                                                                                       Preliminary
                                                                                                   Amendment to be
                                                                                                   filed ASAP.
----------------------------------------------------------------------------------------------------------------------
Shielded Lens              140-038       09/324,232     6/2/99        Bruker         N/A           Pending.
(Continuation of                                                      Daltonics,                   Missing parts
140-021)                                                              Inc.                         filed.
                                                                                                   Preliminary
                                                                                                   Amendment
                                                                                                   to be filed ASAP.
----------------------------------------------------------------------------------------------------------------------
Multiple Ion Trap for      140-039       N/A            N/A           N/A.           N/A           Invention
Othogonal TOFMS                                                                                    Disclosure - NO
                                                                                                   ACTION
----------------------------------------------------------------------------------------------------------------------
Extended Bradbury          140-041       09/344,598     6/25/99       Bruker         N/A           Pending.
Nielson Gate                                                          Daltonics,                   Missing parts
(Continuation of                                                      Inc.                         filed.
140-023)                                                                                           Preliminary
                                                                                                   Amendment to be
                                                                                                   filed ASAP.
----------------------------------------------------------------------------------------------------------------------


Ward and Olivo Status Report For Bruker Daltonics, Inc. As of 03/21/00

------------------------------------------------------------------------------------------------------------------------------
Application Title or        W&O Doc.        Application        Application    Assignee       Patent       Current Status
Project Description         No.             Serial Number      Filing Date                   Number       of Application
                                                                                             Issue Date   or Project
------------------------------------------------------------------------------------------------------------------------------
Ionization Source for       140-042         N/A                N/A            Bruker         N/A          Application
Mass Spectrometry                                                             Daltonics,                  Draft provided
                                                                              Inc.                        to client. To be
                                                                                                          finalized and
                                                                                                          filed ASAP.
------------------------------------------------------------------------------------------------------------------------------
Means and Method for a      140-043         N/A                N/A            Bruker         N/A          Application
Quill Sprayer for                                                             Daltonics,                  Draft provided
Electrospray                                                                  Inc.                        to client. To be
                                                                                                          finalized and
                                                                                                          filed ASAP.
------------------------------------------------------------------------------------------------------------------------------
Method and Apparatus for    140-044         N/A                N/A            Bruker         N/A          Draft being
a Multipole Ion Guide                                                         Daltonics,                  prepared.
for an Electrospray                                                           Inc.
Ionization Source
(HEXAPOLE)
------------------------------------------------------------------------------------------------------------------------------
Method and Apparatus for    140-045         N/A                N/A            Bruker         N/A          Patent
an Electrospray                                                               Daltonics,                  Application
Ionization Source                                                             Inc.                        Filed. Awaiting
(NANOSPRAY)                                                                                               PTO Response.
------------------------------------------------------------------------------------------------------------------------------
Zero Adjust System for      140-047         N/A                N/A            Bruker         N/A          Awaiting More
an E2 Microspray Device                                                       Daltonics,                  Detail From
                                                                              Inc.                        Inventors.
------------------------------------------------------------------------------------------------------------------------------
Method and Apparatus for    140-048         N/A                N/A            Bruker         N/A          Draft being
an Automated Ionization                                                       Daltonics,                  prepared.
System for Mass                                                               Inc.
Spectrometry (MULTIPART
CAPILLARY - ROBOT)
------------------------------------------------------------------------------------------------------------------------------
Mass Spectrometer           140-049         N/A                N/A            Bruker         N/A          Draft being
                                                                              Daltonics,                  prepared.
                                                                              Inc.
------------------------------------------------------------------------------------------------------------------------------
Method for the Automatic    140-050         N/A                N/A            Bruker         N/A          Application
Acquisition, Analysis                                                         Daltonics,                  Draft provided
and Electronic Delivery                                                       Inc.                        to client. To be
of High Resolution Exact                                                                                  finalized and
Mass ESI Mass Spectral                                                                                    filed ASAP.
------------------------------------------------------------------------------------------------------------------------------


Listing of licensed patents and patent applications as of 3/31/00.

No.    Assignee            Technology Covered             Remarks
-----------------------------------------------------------------
1      Indiana             Spatial-Velocity               USPNs:  5,504,326
       University          Correlation Focusing                   5,510,613
                           in Time-of-Flight                      5,712,479
                           Mass Spectrometry              Bruker Daltonics
                                                          holds the exclusive
                                                          right to practice
                                                          these patents.

2      Battelle            Capillary Electro-             USPN   4,842,701
       Memorial            phoresis - Electro-                    RE34,757
       Institute           spray Interface and                   5,423,964
                           Method                         one pending app.
                                                          Japan 2647941
                                                          Canada 1,340,133
                                                          Bruker Daltonics
                                                          has non-exclusive
                                                          rights to practice
                                                          these patents.

3      ISIS Pharma-        "Methods and Apparatus         Pending US patent
       ceuticals, Inc.     for External Accumulation      application. Bruker
                           and Photodissociation of       has exclusive rights
                           Ions Prior to Mass Spectro-    to practice any
                           metric Analysis"               patents issued.

4      Imperial Research   Method for multiplexed         WO 96/27681
       Technology, Ltd.    genotyping                     PCT /GB96/00476
                                                          Bruker Daltonics
                                                          has exclusive right
                                                          to practice this
                                                          patent in
                                                          conjunction with
                                                          mass spectrometry.

Patents acquired via Viking.

No.    Assignee            Technology Covered             Remarks
-----------------------------------------------------------------

1      Bruker Daltonics    Miniaturized Mass              USPN  5,313,061
                           Spectrometer System            Euro. PN 0476062
                                                          German PN
                                                          690283041.0
                                                          UKPN 2249662
                                                          Canadian PN
                                                          2,058,763
                                                          Japanese PN
                                                          Hei-2-509224


Granted Patents: Bruker Daltonik GmbH, Bremen as of 12. Apr. 00


(in Sequence of Priority)

P5047 Family: MM Owner: BFA Priority: 10.03.80 German Title: Eingangskopf eines Mess/Nachweissystems fur chemische Agenzien English Title: Input head of a measuring or identification system for chemical

agents
    Inventors:  Dr. B. Odernheimer  Johannes Kremer  K. Kranich
                DE 3 009 069                          21.10.82
                EP 0 047 286                          16.01.85
                US 4 433 982                          28.02.84

P5048 Family: MM Owner: BFA Priority: 23.09.81 German Title: Verfahren und Vorrichtung zur probenahme von Spurenkomponenten in Gasen, Flussigkeiten, an Festkorpern oder in Oberflachenschichten English Title: Method and device for the sampling of trace elements in gases, liquids, solids or in surface layers
Inventors: Dr. B. Odernheimer

                DE 3 137 765                          27.04.89
                EP 0 089 356                          27.08.86
                US 4 541 268                          17.09.85

P4643             Family: TOF           Owner: BAM        Priority:     10.07.85

German Title: Flugzeitmassenspektrometer mit einem Ionenreflektor English Title: Time-of-flight mass spectrometer using an ion reflector Inventors: Dr. Rudiger Frey Prof. E. W. Schlag

                EP 0 208 894                          23.10.91
                US ???

P5234             Family: CB            Owner: BFA        Priority:     23.12.87

German Title: Verfahren zur massenspektroskopischen Untersuchung eines Gasgemisches und Massenspektrometer zur Durchfuhrung dieses Verfahrens English Title: Method for mass-spectroscopic examination of a gas mixyture and mass spectrometer intended for carrying out this method

    Inventors:  Dr. Jochen Franzen  Dr. R.-H. Gabling  Gerhard Heinen
Gerhard WeiB
                US 5 028 777                          02.07.91

P5242 Family: TOF Owner: BFA Priority: 22.03.88 German Title: Verfahren zum Verdampfen einer Probensubstanz English Title: Method of vaporizing a sample substance Inventors: Prof. E. W. Schlag J. Lindner Prof. R. C. Beavis Prof. J. Grotemeyer

                DE 3 809 504                          21.09.89
                EP 0 333 912                          28.06.95
                US 5 062 935                          05.11.91


BDAL.DE                                                                Page    1


DAR08 Family: CB Owner: USA Priority: 13.04.88 German Title: Verfahren zur massenspektrometrischen Untersuchung eines Gasgemisches und Massenspektrometer zur Durchfuhrung dieses Verfahrens English Title: Method of mass analyzing a sample by use of a quistor and a quistor designed for performing this method

    Inventors:  Dr. Jochen Franzen  Dr. R.-H. Gabling  Gerhard Heinen
Gerhard WeiB
                US 4 882 484                          21.11.89

P5197 Family: CB Owner: BFA Priority: 13.04.88 German Title: Verfahren zur massenspektrometrischen Untersuchung eines Gasgemisches und Massenspektrometer zur Durchfuhrung dieses Verfahrens English Title: Method of mass analyzing a sample by use of a quistor and a quistor designed for performing this method

    Inventors:  Dr. Jochen Franzen  Dr. R.-H. Gabling  Gerhard Heinen
Gerhard WeiB
                EP 0 336 990                          13.04.88

P5464 Family: MM Owner: BFA Priority: 28.05.88 German Title: Verfahren zur nicht intrusiven kontinuierlichen und automatischen Analysenprobennahme, Abspeicherung und Bereitstellung der Proben und Daten fur eine eventuelle Auswertung English Title: Method for non-intrusive continuous and automatic taking of samples, storing and supplying of samples and data for a possible evaluation

    Inventors:  Dr. B. Odernheimer
                CA 1 335 866                          13.06.95
                DE 3 818 210                          23.11.89
                EP 0 407 469                          07.04.93
                Hei7-11475                            07.07.95
                PCT/DE89/00330
                SU 4 831 972
                US 5 216 925                          08.06.93

P5464A            Family: MM            Owner: BFA        Priority:     28.05.88

German Title:
English Title: Apparatus for non-intrusive continuous and automatic taking of samples, storing and supplying of samples and data for a possible evaluation Inventors: Dr. B. Odernheimer
US 5 205 178 27.04.93

P5368 Family: MM Owner: BFA Priority: 15.10.88 German Title: Vorrichtung zur Probenahme fur Uberwachungsfahrzeuge English Title: Sampling device for inspection vehicles Inventors: Dr. Dieter Koch Hans J. Baum

                DE 3 835 207                          03.08.89
                EP 0 364 687                          26.05.93
                US 4 982 616                          08.01.91


BDAL.DE                                                                Page    2


P5357 Family: LC Owner: BFA Priority: 03.11.88 German Title: Flussigkeits-Kolbenpumpe fur chromatographische Analysegerate English Title: Liquid plunger pump for chromatographic analyzer

    Inventors:  Dr. W. Risler

                DE 3 837 325                          03.09.90

P5511             Family: CB            Owner: BFA        Priority:     18.02.89

German Title:
English Title: Method and instrument for mass analyzing samples with a quistor Inventors: Dr. Jochen Franzen Dr. R.-H. Gabling Gerhard Heinen Gerhard WeiB

                DE689 13 290                          26.05.94
                EP 0 383 961                          23.02.94

P5467             Family: TOF           Owner: BFA        Priority:     23.06.89
  German Title: MS-MS-Flugzeitmassenspektrometer
  English Title: MS-MS time-of-flight mass spectrometer
    Inventors:  Priv.Doz. U. Boesl  Prof. E. W. Schlag  R. Weinkauf  K. Walter
                DE 3 920 566                          01.04.93
                EP 0 403 965                          15.09.94
                US 5 032 722                          16.07.91

DAR15 Family: CB Owner: USA Priority: 18.12.89 German Title:
English Title: Method and instrument for mass analyzing samples with a quistor Inventors: Dr. Jochen Franzen Dr. R.-H. Gabling Gerhard Heinen

Gerhard WeiB
                US 4 975 577                          04.12.90

P5505             Family: XQ            Owner: BFA        Priority:     08.01.90

German Title:
English Title: Generation of an exact three-dimensional quadrupole electric field
Inventors: Dr. Yang Wang

                CA 2 033 753                          21.11.95
                EP 0 509 986                          31.05.95
                US 5 283 436                          01.02.94

B2321             Family: XQ            Owner: BFA        Priority:     29.05.90

German Title: Masenspektrometrischer Hochfrequenz-Quadrupolkafig mit uberlagerten Multipolfeldern
English Title: Mass spectrometric high-frequency quadrupole cage with overlaid multipole fields
Inventors: Dr. Jochen Franzen

                DE 4 017 264                          22.06.92
                US 5 170 054                          08.12.92


BDAL.DE                                                                Page    3


B2326 Family: EM Owner: BFA Priority: 02.07.90 German Title: Verfahren und Vorrichtung zum Extrahieren geloster fluchtiger Substanzen aus Flussigkeiten in die Gasphase English Title: Method and apparatus for extracting dissolved, volatile substances from liquids into the vapor phase Inventors: Dr. Gokhan Baykut

                DE 4 021 239                          17.05.94
                US 5 258 057                          02.11.93

B2442             Family: TOF           Owner: BFA        Priority:     13.03.91

German Title: Verfahren und Vorrichtung zum Erzeugen von Ionen aus thermisch instabilen, nichtfluchtigen gro(beta)en Molekulen English Title: Method and Apparatus for generating ions from thermally unstable, non-volatile, large molecules, particularly for a mass spectrometer such as a time-of-flight mass spectrometer Inventors: Dr. Rudiger Frey Dr. Armin Holle Gerhard WeiB

                DE 4 108 462                          28.04.94
                EP 0 503 748                          11.12.96
                US 5 294 797                          28.04.94

B2524             Family: TOF           Owner: BFA        Priority:     05.09.91

German Title: Verfahren und Detektor zum Nachweis schwerer Molekulionen in einem Flugzeitmassenspektrometer
English Title: Method and detector for detecting heavy molecule ions in a time-of-flight mass
Inventors: Dr. Armin Holle
DE 4 129 791 17.06.93

B2534 Family: XQ Owner: BFA Priority: 27.11.91 German Title: Verfahren zum Isolieren von Ionen einer auswahlbaren Masse English Title: Method of clean removal of ions Inventors: Dr. Jochen Franzen

                DE 4 139 037                          13.03.95
                GB 2 261 988                          10.05.95
                US 5 331 157                          19.07.94

01/91             Family: XQ            Owner: BFA        Priority:     23.12.91

German Title: Verfahren und Vorrichtung fur phasenrichtige Anregung des Ionenauswurfs aus Ionenfallen-Massenspektrometern English Title: Method and device for in-phase excitation of ion ejection from ion trap mass spectrometers
Inventors: Dr. Jochen Franzen

                DE 41 42 871                          19.05.93
                GB 9 226 835                          03.05.95
                US 5 347 127                          13.09.94


BDAL.DE                                                                Page    4


02/91 Family: XQ Owner: BFA Priority: 23.12.91 German Title: Verfahren fur phasenrichtiges Messen der Ionen aus Ionenfallen-Massenspektrometern
English Title: Method and device for in-phase measuring of ions from ion trap mass spectrometers
Inventors: Dr. Jochen Franzen

                DE 41 42 870                          17.10.94
                GB 2 263 192                          10.05.95
                US 5 386 113                          31.01.95

03/91             Family: XQ            Owner: BFA        Priority:     23.12.91

German Title: Verfahren und Vorrichtung fur die Steuerung der Anregungsspannung fur den Ionenauswurf aus Ionenfallen-Massenspektrometern
English Title: Method and device for control of the excitation voltage for ion ejection from ion trap mass spectrometers Inventors: Dr. Jochen Franzen

                DE 41 42 869                          19.05.93
                GB 2 263 191                          30.08.95
                US 5 298 746                          29.03.94

01/92             Family: EM            Owner: BFA        Priority:     20.01.92

German Title: Einla(beta)ventil fur ein Hochvakuum-Analysengerat mit Bypass-Bepumpung
English Title: Inlet valve for a high vacuum analyzer with a bypass evacuation Inventors: Dr. Jochen Franzen Gerhard WeiB Alfred Kraffert

                GB 2 263 534                          17.05.95
                US 5 404 765                          11.04.95

03/92             Family: XQ            Owner: BFA        Priority:     27.01.92

German Title: Vorrichtung fur die massenspektrometrische Untersuchung schneller organischer Ionen
English Title: Method and device for the mass spectrometric examination of fast organic ions
Inventors: Dr. Jochen Franzen

                DE 42 02 123                          02.11.94
                US 5 373 156                          13.12.94

04/92             Family: EM            Owner: BFA        Priority:     27.02.92

German Title: Verfahren und Vorrichtung zur Aufbereitung fester Proben mit Hilfe pyrolytischer Verdampfung fur eine Analyse mittels eines Massenspektrometers oder eines Gaschromatographen

  English Title:
    Inventors:  Dr. Gokhan Baykut  Anatoly Schiller
                DE 42 06 109                          24.01.94


BDAL.DE                                                                Page    5


P5997 Family: MM Owner: BFA Priority: 13.11.92 German Title: Mobiles Massenspektrometer mit einer Probenahmevorrichtung mit drehbarem Spurrad mit Metallfelge
English Title: Sampling device comprising a revolvable sampling wheel with a

metal wheel rim
    Inventors:  Dr. Dieter Koch  G. Menne  Alfred Kraffert  R. Spudich
Gerhard WeiB
                DE 4 238 399                          27.08.93
                FR 9 312 064                          22.12.95
                GB 2 272 518                          10.07.96
                US 5 437 203                          01.08.95

10/93             Family: TOF           Owner: BFA        Priority:     26.02.93

German Title: Verfahren und Vorrichtung zur quantitativen Analyse von Gasgemischen mittels resonanter Laser-Massenspektrometrie bei stark fluktuierenden Me(beta)signalen
English Title:
Inventors: Christian Weikhardt Priv.Doz. U. Boesl Prof. E. W. Schlag

DE 43 05 981

01/93 Family: XQ Owner: BFA Priority: 19.05.93 German Title: Verfahren zur digitalen Erzeugung einer zusatzlichen Wechselspannung fur die resonante Anregung von Ionen in Ionenfallen English Title: Method and device for the digital generation of an additional alternating voltage for the resonant excitation of ions in an ion trap Inventors: Dr. Jochen Franzen Gerhard Heinen Dr. R.-H. Gabling

                DE 43 16 737                          01.09.94
                GB 2 278 233                          23.04.97
                US 5 438 195                          01.08.95

02/93             Family: XQ            Owner: BFA        Priority:     19.05.93

German Title: Auswurf von Ionen aus Ionenfallen durch kombinierte elektrische Dipol- und Quadrupolfelder
English Title: Ejection of ions from ion traps by combined electrical dipole and quadrupole fields
Inventors: Dr. Jochen Franzen

                DE 43 16 738                          17.10.96
                GB 2 278 232                          28.05.97
                US 5 468 957                          21.11.95

03/93             Family: TOF           Owner: BFA        Priority:     20.05.93

German Title: Nachweis schwerer Ionen in einem Flugzeitmassenspektrometer English Title: Detection of very large molecular ions in a time-of-flight mass spectrometer
Inventors: Dr. Armin Holle

                DE 43 16 805                          06.03.97
                GB 2 278 494                          25.09.96
                US 5 463 218                          31.10.95


BDAL.DE                                                                Page    6


04/93 Family: XQ Owner: BFA Priority: 20.07.93 German Title: Quadrupol-Ionenfallen mit schaltbaren Multipolanteilen English Title: Quadrupole ion trap with switchable multipole fractions Inventors: Dr. Jochen Franzen Dr. Yang Wang

                DE 43 24 224                          06.10.94
                GB 2 280 305                          02.04.97
                US 5 468 958                          21.11.95

05/93             Family: XQ            Owner: BFA        Priority:     20.07.93

German Title: Verfahren zur Auswahl der Reaktionspfade in Ionenfallen English Title: Method of selecting reaction paths in ion traps Inventors: Dr. Jochen Franzen Dr. R.-H. Gabling

                DE 43 24 233                          31.08.94
                GB 2 280 304                          06.08.97
                US 5 521 379                          28.05.96

06/93             Family: XQ            Owner: BFA        Priority:     07.08.93

German Title: Verfahren fur eine Regelung der Raumladung in Ionenfallen English Title: Method of automatically controlling the space charge in ion traps
Inventors: Dr. Jochen Franzen

                DE 43 26 549                          08.04.94
                GB 2 280 781                          05.03.97
                US 5 559 325                          24.09.96

02/94             Family: XQ            Owner: BFA        Priority:     10.03.94

German Title: Verfahren zur Ionisierung von gelosten Atomen oder Molekulen aus Flussigkeiten durch elektrisches Verspruhen English Title: Method of ionizing atoms or molecules by electrospraying Inventors: Dr. Matthias Mann Matthias Wilm US 5 504 329 02.04.96

03/94 Family: TOF Owner: BFA Priority: 10.03.94 German Title: Verfahren zur massenspektrometrischen Analyse von Proben aus 2-D-Gel-Elektrophoreseplatten mit matrixunterstutzter, ionisierender Laserdesorption
English Title: Method for mass spectrometric analysis of samples from electrophoresis plates
Inventors: Dr. Jochen Franzen

                DE 44 08 034                          01.03.95
                GB 2 280 304                          06.08.97
                US 5 595 636                          21.01.97

04/94             Family: CB            Owner: BFA        Priority:     29.04.94

German Title: Virtueller Impaktor mit schlitzformigen Dusen English Title: Virtual impactor
Inventors: Dr. Ulrich Geise

                DE 44 15 014                          29.07.96
                GB 2 280 305                          02.04.97
                US 5 533 406                          09.07.96


BDAL.DE                                                                Page    7


06/94 Family: XQ Owner: BFA Priority: 03.05.94 German Title: Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisation (ESI) English Title: Device and method for mass spectrometric analysis of substance mixtures by coupling capillary electrophoretic separation (CE) with electrospray

ionization (ESI)
    Inventors:  Dr. Jochen Franzen  Dr. Frank Laukien
                DE 44 15 480                          02.09.99
                GB 2 289 161                          08.04.98
                US 5 505 832                          09.04.96

07/94 Family: XQ Owner: BFA Priority: 19.07.94 German Title: Verfahren zur Sto(beta)induzierten Fragmentierung von Ionen in Ionenfallen
English Title: Collisionally induced decomposition of ions in nonlinear ion traps
Inventors: Dr. Jochen Franzen

                DE 44 25 384                          16.06.95
                GB 2 291 534                          18.02.98
                US 5 528 031                          18.06.96

08/94             Family: XQ            Owner: BFA        Priority:     25.11.94

German Title: Verfahren und Vorrichtung zur Elektrospruh-Ionisierung fur speichernde Massenspektrometer
English Title: Electrospraying Method for mass spectrometric analysis Inventors: Dr. Jochen Franzen Dr. Matthias Mann Matthias Wilm

                DE 44 44 229                          25.07.96
                GB 2 288 061                          15.10.97
                US 5,608,217

P6403             Family: TOF           Owner: BFA        Priority:     29.11.94

German Title: Verfahren und Vorrichtung zur verbesserten Massenauflosung eines Flugzeitmassenspektrometers mit Ionenreflektor English Title: Device and method for the improved mass resolution of time-of-flight mass spectrometer with ion reflector

    Inventors:  Dr. Frank Laukien  Prof. J. Grotemeyer  Dr. Claus Koster
Johann Grundwurmer
                DE 44 42 348
                GB 9 524 247                          29.07.98
                US 5,739,529                          14.04.98

11/95 Family: XQ Owner: BFA Priority: 21.01.95 German Title: Verfahren zur Anregung der Schwingungen von Ionen in Ionenfallen mit Frequenzgemischen
English Title: Method for exciting the oscillations of ions in ion traps with

frequency mixtures
    Inventors:  Dr. Jochen Franzen  Dr. Michael Schubert
                DE 195 01 835                         08.01.98
                GB 2 297 192                          28.10.98
                US 5 654 542


BDAL.DE                                                                Page    8


12/95 Family: XQ Owner: BFA Priority: 21.01.95 German Title: Verfahren zur Regelung der Erzeugungsrate fur massenselektives Einspeichern von Ionen in Ionenfallen
English Title: Method for controlling the ion generation rate for mass selective loading of ions in ion traps

Inventors:  Dr. Jochen Franzen  Dr. Michael Schubert
            GB 2 297 191                          04.11.98
            US 5,710,427                          20.01.98

13/95 Family: CB Owner: BFA Priority: 09.02.95 German Title: Virtuelle Impaktoren mit schlitzformigen Dusen ohne Schlitzende English Title: Virtual impactors with slit shaped nozzles without slit ends

    Inventors:  Dr. Ulrich Geise

                DE 195 04 275                         10.02.00
                GB 2 297 706                          28.07.99
                US 5,858,043                          12.01.99

16/95             Family: XQ            Owner: BFA        Priority:     28.03.95
  German Title:
  English Title: Method for ionization of heavy molecules at atmospheric
pressure
    Inventors:  Dr. Jochen Franzen  Dr. Claus Koster
                GB 2 299 445                          09.12.98
                US 5 663 561                          02.09.97

17/95 Family: TOF Owner: BFA Priority: 28.03.95 German Title: Verfahren und Vorrichtung fur orthogonalen Einschu(beta)von Ionen in ein Flugzeit-Massenspektrometer English Title: Method and device for orthogonal ion injection into a time-of-flight mass spectrometer
Inventors: Dr. Jochen Franzen

                DE 195 11 333                         26.03.96
                GB 2 299 446                          25.11.98
                US 5,763,878                          09.06.98

18/95             Family: IMS           Owner: BSA        Priority:     26.04.95

German Title: Verfahren zur Messung von Ionenmobilitatsspektren English Title: Method of measuring ion mobility spectra Inventors: Dr. Jochen Franzen

                GB 2 300 296                          09.06.99
                US 5 719 392                          17.02.98

19/95             Family: XQ            Owner: BFA        Priority:     26.04.95

German Title: Vorrichtung fur den gasgefuhrten Transport von Ionen durch Kapillarrohr
English Title: Method and device for transport of ions in gas through a capillary
Inventors: Dr. Jochen Franzen

                DE 195 15 271                         02.09.99
                GB 2 300 295                          14.10.98
                US 5,736,740                          07.04.98


BDAL.DE                                                                Page    9


20/95 Family: XQ Owner: BFA Priority: 12.05.95 German Title: Hochfrequenz-Ionenleitsystem English Title: Method and device for the transport of ions in vacuum Inventors: Dr. Jochen Franzen

                DE 19 517 507                         21.03.96
                GB 2 300 751                          23.12.98
                US 5 708 268                          13.01.98

22/95             Family: XQ            Owner: BFA        Priority:     02.06.95

German Title: Vorrichtung fur die Einfuhrung von Ionen in ein Massenspektrometer
English Title: Method and device for the introduction of ions into the gas stream of an aperture to a mass

                 spectrometer
    Inventors:  Dr. Jochen Franzen
                DE 195 20 276                         26.08.99
                GB 2 301 703                          22.10.99
                US 5,747,799                          05.05.98

23/95             Family: XQ            Owner: BFA        Priority:     02.06.95

German Title:
English Title: Method and device for the introduction of ions into quadrupole ion traps
Inventors: Dr. Jochen Franzen

                GB 2 301 705                          10.01.00
                US 5,739,530                          14.04.98

24/95             Family: XQ            Owner: BFA        Priority:     29.06.95

German Title: Ionenfallen-Massenspektrometer mit vakuum-externer Ionenerzeugung
English Title: Ion trap mass spectrometer with vacuum-external ion generation Inventors: Dr. Jochen Franzen

                GB 2 302 984                          10.11.99
                US 5,859,433                          12.01.99

25/95             Family: XQ            Owner: BFA        Priority:     30.06.95

German Title: Verfahren und Vorrichtung fur die Reflektion von geladenen Teilchen
English Title: Method and device for the reflection of charged particles on surfaces
Inventors: Dr. Jochen Franzen

                DE 195 23 859
                GB 2 302 985                          12.01.00
                US 5 572 035                          05.11.96

26/95             Family: XQ            Owner: BFA        Priority:     14.09.95

German Title: Zwischenspeichern von Ionen fur massenspektrometrische Untersuchungen
English Title: Temporary storage of ions for mass spectrometric analyses Inventors: Dr. Jochen Franzen Dr. Michael Schubert

                EP 0 738 000 A                        16.02.00
                US 5,811,800                          22.09.98


BDAL.DE                                                                Page   10


28/95 Family: TOF Owner: BFA Priority: 19.09.95 German Title: Verbesserte Massenauflosung in Flugzeitmassenspektrometern mit Reflektoren
English Title: Mass Resolution in time-of-flight mass spectrometers with

reflectors
    Inventors:  Dr. Armin Holle  Dr. Claus Koster  Dr. Jochen Franzen
                US 5 654 545                          05.08.97

30/95 Family: TOF Owner: BFA Priority: 27.11.95 German Title: Verfahren und Vorrichtungen zur Massenspektrometrie von Tochterionen
English Title: Method for time-of-flight mass spectrometry of daughter ions Inventors: Dr. Claus Koster

                DE 195 44 808
                US 5,734,161                          31.03.98

31/95             Family: TOF           Owner: BFA        Priority:     14.12.95

German Title: Flugzeitmassenspektrometrie verbesserter Massenauflosung durch Schalten einer Zwischenblende
English Title: Method for improved mass resolution with a TOF-LD source Inventors: Dr. Armin Holle Dr. Claus Koster Dr. Jochen Franzen US 5 641 959 24.06.97

32/95 Family: TOF Owner: BFA Priority: 15.12.95 German Title: Flugzeitmassenspektrometrie mit verbesserter Massenauflosung English Title: Methjod of improving mass resolution in time-of-flight mass

spectrometry
    Inventors:  Dr. Armin Holle  Dr. Claus Koster  Dr. Jochen Franzen
                US 195 47 949
                US 5,742,049                          21.04.98

34/96 Family: TOF Owner: BFA Priority: 24.04.96 German Title: Verfahren zur matrix-unterstutzten ionisierenden Laserdesorption English Title: Method for matrix-assisted laser desorption and ionization Inventors: Dr. Claus Koster Dr. Jochen Franzen US 5,828,063 27.11.98

36/96 Family: TOF Owner: BFA Priority: 03.05.96 German Title: Lagerfahig vorpraparierte MALDI-Probentrager English Title: Prefabricated MALDI layers suitable for storage Inventors: Dr. Claus Koster Dr. Jochen Franzen Dr. Detlef Suckau

DE 196 18 032

37/96 Family: XQ Owner: BFA Priority: 20.06.96 German Title: Vorrichtung und Verfahren zum Einschuss von Ionen in eine Ionenfalle
English Title: Method and device for injection of ions into an ion trap Inventors: Dr. Jochen Franzen

                DE 196 28 179                         24.11.97
                US 5,818,055                          06.10.98


BDAL.DE                                                                Page   11


38/96 Family: TOF Owner: BFA Priority: 01.07.96 German Title: Vorrichtung zum Einschleusen von Probentragern in ein Massenspektrometer
English Title: Device and method for introduction of sample supports into a

mass spectrometer
    Inventors:  Dr. Armin Holle  Dr. Claus Koster  Rebettge
                US 5,841,136                          24.11.98

39/96 Family: TOF Owner: BFA Priority: 02.07.96 German Title: Verfahren zum Beladen von Probentragern fur Massenspektrometer English Title: Method for loading sample supports for mass spectrometers Inventors: Dr. Jochen Franzen

                DE 196 28 178                         18.09.97
                US 5,770,860                          23.06.98

41/96             Family: TOF           Owner: BFA        Priority:     15.08.96

German Title: Verfahren und Vorrichtung fur die genaue Massenbestimmung in einem Flugzeitmassenspektrometer
English Title: Adjustment of sample support in time-of-flight mass

spectrometers
    Inventors:  Dr. Claus Koster  Dr. Armin Holle  Dr. Jochen Franzen
                DE 196 33 441                         26.02.98
                US 5,910,656                          08.06.99

42/96 Family: ICR Owner: BFA Priority: 19.08.96 German Title: Vorrichtung zur Uberfuhrung von Ionen und mit dieser durchgefuhrtes Messverfahren
English Title: Introduction of ions from ion sources into mass spectrometers Inventors: Dr. Gokhan Baykut

                DE 196 29 134
                US 5,825,026                          20.10.98

43/96             Family: TOF           Owner: BFA        Priority:     20.08.96
  German Title: Genaue Massensbestimmung mit MALDI-Flugzeitmassenspektrometern
  English Title: Exact mass determination with MALDI time-of-flight mass
spectrometers
    Inventors:  Dr. Jochen Franzen  Dr. Claus Koster
                DE 196 33 507                         21.12.97
                US 5,869,830                          09.02.99

44/96 Family: TOF Owner: BFA Priority: 30.08.96 German Title: Korrektur der Massenbestimmung mit MALDI-Flugzeitmassenspektrometern
English Title: Accurate mass determination with MALDI time-of-flight mass spectrometers using internal
reference substances

    Inventors:  Dr. Claus Koster  Dr. Jochen Franzen  Dr. Armin Holle
                DE 196 35 646                         29.01.98
                US 5,886,345                          23.03.99


BDAL.DE                                                                Page   12


45/96 Family: TOF Owner: BFA Priority: 30.08.96 German Title: Hochstauflosendes lineares Flugzeitmassenspektrometer English Title: Linear time-of-flight mass spectrometer with high mass resolution
Inventors: Dr. Jochen Franzen

US 5,905,259 18.05.99

46/96 Family: TOF Owner: BFA Priority: 31.08.96 German Title: Hochauflosende Ionendetektion fur lineare Flugzeitmassenspektrometer
English Title: High resolution ion detection for linear time-of-flight mass spectrometers
Inventors: Dr. Jochen Franzen

US 5,898,173 27.04.99

47/96 Family: TOF Owner: BFA Priority: 09.09.96 German Title: Hochstauflosende Geometrie fur lineares Flugzeitmassenspektrometer
English Title: Geometry for a linear time-of-flight mass spectrometer with very high resolution
Inventors: Dr. Jochen Franzen

US 5,898,174 27.04.99

48/96 Family: TOF Owner: BFA Priority: 13.09.96 German Title: Simultane Fokussierung aller Massen in Flugzeitmassenspektrometern
English Title: Wide mass range focusing in time-of-flight mass spectrometers Inventors: Dr. Jochen Franzen

                DE 196 38 577                         15.01.98
                US 5,969,348                          19.10.99

50/97             Family: TOF           Owner: BFA        Priority:     24.02.97

German Title: Zwei-Schritt-Verfahren der DNA-Amplifikation fur MALDI-TOF-Messungen
English Title: Two-step method of DNA amplification for MALDI-TOF measurement Inventors: Dr. Ivo Gut Dr. Jochen Franzen DE 197 10 166 10.12.98

51/97 Family: XQ Owner: B+H Priority: 04.03.97 German Title: Verfahren der vergleichenden Analyse mit Ionenfallen-Massenspektrometern
English Title: Methods of comparative analyses using ion trap mass spectrometers
Inventors: Dr. Michael Schubert Dr. John Fjeldsted Dr. Jochen Franzen US 5,903,003 11.05.99

52/97 Family: XQ Owner: B+H Priority: 04.03.97 German Title: Verfahren der Raumladungsregelung von Tochterionen in Ionenfallen
English Title: Method for space-charge control of daughter ions in ion traps Inventors: Dr. Jochen Franzen Dr. Michael Schubert US 5,936,241 10.08.99

BDAL.DE Page 13


53/97 Family: TOF Owner: BFA Priority: 14.04.97 German Title: Verfahren und Gerate fur extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
English Title: Methods for extremely fast DNA replication by polymerase chain reactions (PCR)
Inventors: Dr. Jochen Franzen
DE 197 17 085 17.06.99

54/97 Family: XQ Owner: B+H Priority: 04.08.97 German Title: Axialsymmetrische Ionenfalle fur massenspektrometrische Messungen
English Title: Ion trap mass spectrometer of high mass-constancy Inventors: Gerhard WeiB Alfred Kraffert Dr. Michael Schubert Dr. Jochen Franzen
DE 197 33 834 04.03.99

55/97 Family: TOF Owner: BFA Priority: 30.08.97 German Title: Flugzeitmassenspektrometer mit thermokompensierter Fluglange English Title: Time-of-flight mass spectrometer with constant flight path length
Inventors: Dr. Jochen Franzen

US 6,049,077 11.04.00

59/97 Family: TOF Owner: BFA Priority: 08.12.97 German Title: Probentrager fur die MALDI-Massenspektrometrie nebst Verfahren zur Herstellung der Platten und zum Aufbringen der Proben English Title: Sample support plates for MALDI mass spectrometry including methods for manufacture of plates and application of samples Inventors: Dr. Martin Dr. Jochen Franzen
DE 197 54 978

61/98 Family: TOF Owner: BFA Priority: 26.01.98 German Title: Massenspektrometrisches Verfahren zur genauen Massenbestimmung unbekannter Ionen
English Title: Mass spectrometry method for accurate mass determination of unknown ions
Inventors: Dr. Claus Koster
DE 198 03 309 07.10.99

62/98 Family: TOF Owner: BFA Priority: 23.02.98 German Title: Verfahren zur qualitativen Schnellauswertung analytischer Massenspektren
English Title: Method of fast evaluation of analytical mass spectra Inventors: Dr. Jochen Franzen
DE 198 08 584 26.08.99

66/98 Family: TOF Owner: BFA Priority: 10.06.98 German Title: Thermostabile Flugzeiten in Flugzeitmassenspektrometern English Title: Method and apparatus for thermally stabilizing flight times in time-of-flight mass spectrometers
Inventors: Horst Rache
DE 198 27 841 10.02.00

BDAL.DE Page 14


71/98 Family: DA Owner: BFA Priority: 28.09.98 German Title: Verfahren fur die interaktive Steuerung von Me(beta)- oder Auswerteverfahren in Chromatographie, Spektroskopie oder Elektrophorese English Title: Method of using the mouse for interactive control in chromatography or spectroscopy
Inventors: Dr. Carsten Bassmann
DE 198 45 699 02.12.99

BDAL.DE Page 15


Bruker Daltonik GmbH, Bremen:  Patent Applications      as of 12. Apr. 00
  (in sequence of priority dates)
  P5511           Family: CB            Owner: BFA        Priority:     18.02.89

German Titel:
English Titel: Method and instrument for mass analyzing samples with a quistor Inventors: Dr. Jochen Franzen Dr. R.-H. Gabling Gerhard Heinen Gerhard WeiB

P5997 Family: MM Owner: BFA Priority: 13.11.92 German Title: Mobiles Massenspektrometer mit einer Probenahmevorrichtung mit drehbarem Spurrad mit Metallfelge
English Titel: Sampling device comprising a revolvable sampling wheel with a metal wheel rim
Inventors: Dr. Dieter Koch G. Menne Alfred Kraffert R. Spudich Gerhard WeiB

18/95 Family: IMS Owner: BSA Priority: 26.04.95 German Title: Verfahren zur Messung von Ionenmobilitatsspektren English Titel: Method of measuring ion mobility spectra Inventors: Dr. Jochen Franzen

28/95 Family: TOF Owner: BFA Priority: 19.09.95 German Title: Verbesserte Massenauflosung in Flugzeitmassenspektrometern mit Reflektoren
English Titel: Mass Resolution in time-of-flight mass spectrometers with reflectors
Inventors: Dr. Armin Holle Dr. Claus Koster Dr. Jochen Franzen

30/95 Family: TOF Owner: BFA Priority: 27.11.95 German Title: Verfahren und Vorrichtungen zur Massenspektrometrie von Tochterionen
English Titel: Method for time-of-flight mass spectrometry of daughter ions Inventors: Dr. Claus Koster

32/95 Family: TOF Owner: BFA Priority: 15.12.95 German Title: Flugzeitmassenspektrometrie mit verbesserter Massenauflosung English Titel: Methjod of improving mass resolution in time-of-flight mass spectrometry
Inventors: Dr. Armin Holle Dr. Claus Koster Dr. Jochen Franzen

33/96 Family: TOF Owner: BFA Priority: 08.03.96 German Title: Ionisierung schwerer Molekule bei Atmospharendruck English Titel: Method for the ionization of heavy molecules at atmospheric

pressure
     Inventors:  Dr. Jochen Franzen  Dr. Claus Koster


BDAL.DE  Patent                                                        Page    1


34/96 Family: TOF Owner: BFA Priority: 24.04.96 German Title: Verfahren zur matrix-unterstutzten ionisierenden Laserdesorption English Titel: Method for matrix-assisted laser desorption and ionization Inventors: Dr. Claus Koster Dr. Jochen Franzen

GB 2 299 445 A

36/96 Family: TOF Owner: BFA Priority: 03.05.96 German Title: Lagerfahig vorpraparierte MALDI-Probentrager English Titel: Prefabricated MALDI layers suitable for storage Inventors: Dr. Claus Koster Dr. Jochen Franzen Dr. Detlef Suckau

37/96 Family: XQ Owner: BFA Priority: 20.06.96 German Title: Vorrichtung und Verfahren zum Einschuss von Ionen in eine Ionenfalle
English Titel: Method and device for injection of ions into an ion trap Inventors: Dr. Jochen Franzen

38/96 Family: TOF Owner: BFA Priority: 01.07.96 German Title: Vorrichtung zum Einschleusen von Probentragern in ein Massenspektrometer
English Titel: Device and method for introduction of sample supports into a mass spectrometer
Inventors: Dr. Armin Holle Dr. Claus Koster Jens Rebettge

39/96 Family: TOF Owner: BFA Priority: 02.07.96 German Title: Verfahren zum Beladen von Probentragern fur Massenspektrometer English Titel: Method for loading sample supports for mass spectrometers Inventors: Dr. Jochen Franzen

41/96 Family: TOF Owner: BFA Priority: 15.08.96 German Title: Verfahren und Vorrichtung fur die genaue Massenbestimmung in einem Flugzeitmassenspektrometer
English Titel: Adjustment of sample support in time-of-flight mass spectrometers
Inventors: Dr. Claus Koster Dr. Armin Holle Dr. Jochen Franzen

42/96 Family: ICR Owner: BFA Priority: 19.08.96 German Title: Vorrichtung zur Uberfuhrung von Ionen und mit dieser durchgefuhrtes Messverfahren
English Titel: Introduction of ions from ion sources into mass spectrometers Inventors: Dr. Gokhan Baykut

BDAL.DE Patent Page 2


43/96 Family: TOF Owner: BFA Priority: 20.08.96 German Title: Genaue Massensbestimmung mit MALDI-Flugzeitmassenspektrometern English Titel: Exact mass determination with MALDI time-of-flight mass spectrometers
Inventors: Dr. Jochen Franzen Dr. Claus Koster

44/96 Family: TOF Owner: BFA Priority: 30.08.96 German Title: Korrektur der Massenbestimmung mit MALDI-Flugzeitmassenspektrometern
English Titel: Accurate mass determination with MALDI time-of-flight mass spectrometers using internal reference substances Inventors: Dr. Claus Koster Dr. Jochen Franzen Dr. Armin Holle

45/96 Family: TOF Owner: BFA Priority: 30.08.96 German Title: Hochstauflosendes lineares Flugzeitmassenspektrometer English Titel: Linear time-of-flight mass spectrometer with high mass resolution
Inventors: Dr. Jochen Franzen

46/96 Family: TOF Owner: BFA Priority: 31.08.96 German Title: Hochauflosende Ionendetektion fur lineare Flugzeitmassenspektrometer
English Titel: High resolution ion detection for linear time-of-flight mass spectrometers
Inventors: Dr. Jochen Franzen

47/96 Family: TOF Owner: BFA Priority: 09.09.96 German Title: Hochstauflosende Geometrie fur lineares Flugzeitmassenspektrometer
English Titel: Geometry for a linear time-of-flight mass spectrometer with very high resolution
Inventors: Dr. Jochen Franzen

48/96 Family: TOF Owner: BFA Priority: 13.09.96 German Title: Simultane Fokussierung aller Massen in Flugzeitmassenspektrometern
English Titel: Wide mass range focusing in time-of-flight mass spectrometers Inventors: Dr. Jochen Franzen

49/96 Family: TOF Owner: BFA Priority: 25.10.96 German Title: Hochauflosender Hochmassendetektor fur Flugzeitmassenspektrometer
English Titel: Ion detector
Inventors: Dr. Claus Koster

BDAL.DE Patent Page 3


50/97 Family: TOF Owner: BFA Priority: 24.02.97 German Title: Zwei-Schritt-Verfahren der DNA-Amplifikation fur MALDI-TOF-Messungen
English Titel: Two-step method of DNA amplification for MALDI-TOF measurement Inventors: Dr. Ivo Gut Dr. Jochen Franzen

51/97 Family: XQ Owner: B+H Priority: 04.03.97 German Title: Verfahren der vergleichenden Analyse mit Ionenfallen-Massenspektrometern
English Titel: Methods of comparative analyses using ion trap mass spectrometers
Inventors: Dr. Michael Schubert Dr. John Fjeldsted Dr. Jochen Franzen

52/97 Family: XQ Owner: B+H Priority: 04.03.97 German Title: Verfahren der Raumladungsregelung von Tochterionen in Ionenfallen
English Titel: Method for space-charge control of daughter ions in ion traps Inventors: Dr. Jochen Franzen Dr. Michael Schubert

GB 2 322 961

53/97 Family: TOF Owner: BFA Priority: 14.04.97 German Title: Verfahren und Gerate fur extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
English Titel: Methods for extremely fast DNA replication by polymerase chain reactions (PCR)
Inventors: Dr. Jochen Franzen

54/97 Family: XQ Owner: B+H Priority: 04.08.97 German Title: Axialsymmetrische Ionenfalle fur massenspektrometrische Messungen
English Titel: Ion trap mass spectrometer of high mass-constancy Inventors: Gerhard WeiB Alfred Kraffert Dr. Michael Schubert Dr. Jochen Franzen

55/97 Family: TOF Owner: BFA Priority: 30.08.97 German Title: Flugzeitmassenspektrometer mit thermokompensierter Fluglange English Titel: Time-of-flight mass spectrometer with constant flight path length
Inventors: Dr. Jochen Franzen

GB 2 329 066

BDAL.DE Patent Page 4


56/97 Family: XQ Owner: B+H Priority: 17.11.97 German Title: Quadrupol-Hochfrequenz-Ionenfallen fur Massenspektrometer English Titel: Quadrupole RF ion traps for mass spectrometers Inventors: Dr. Jochen Franzen Prof.Dr. Arne Kasten

57/97 Family: XQ Owner: B+H Priority: 25.11.97 German Title: Vorselektion extern erzeugter Ionen fur Quadrupol-Ionenfallen English Titel: Preselection of externally generated ions for quadrupole ion traps
Inventors: Dr. Michael Schubert Dr. Jochen Franzen

59/97 Family: TOF Owner: BFA Priority: 08.12.97 German Title: Probentrager fur die MALDI-Massenspektrometrie nebst Verfahren zur Herstellung der Platten und zum Aufbringen der Proben English Titel: Sample support plates for MALDI mass spectrometry including methods for manufacture of plates and application of samples Inventors: Dr. Martin Schurenberg Dr. Jochen Franzen

60/98 Family: TOF Owner: BFA Priority: 19.01.98 German Title: Verfahren zur bevorzugten Herstellung nur eines Stranges selektierten Genmaterials fur massenspektrometrische Messungen English Titel: Method for preferred production of only one strand of selected genetic material for mass spectrometric measurements Inventors: Dr. Jorn Mosner Dr. Jochen Franzen

61/98 Family: TOF Owner: BFA Priority: 26.01.98 German Title: Massenspektrometrisches Verfahren zur genauen Massenbestimmung unbekannter Ionen
English Titel: Mass spectrometry method for accurate mass determination of unknown ions
Inventors: Dr. Claus Koster

BDAL.DE Patent Page 5


62/98 Family: TOF Owner: BFA Priority: 23.02.98 German Title: Verfahren zur qualitativen Schnellauswertung analytischer Massenspektren
English Titel: Method of fast evaluation of analytical mass spectra Inventors: Dr. Jochen Franzen

65/98 Family: TOF Owner: BFA Priority: 30.04.98 German Title: Mutationsanalyse mitteld Massenspektrometrie English Titel: Mutation analysis using mass spectrometry Inventors: Dr. Ivo Gut

66/98 Family: TOF Owner: BFA Priority: 10.06.98 German Title: Thermostabile Flugzeiten in Flugzeitmassenspektrometern English Titel: Method and apparatus for thermally stabilizing flight times in time-of-flight mass spectrometers
Inventors: Horst Rache
GB 2 338 824

67/98 Family: TOF Owner: BFA Priority: 15.06.98 German Title: Ionisierung hochmolekularer Substanzen durch Laserdesorption aus flussigen Matrices
English Titel: Ionization of high-molecular substances by laser desorption from liquid matrices
Inventors: Dr. Claus Koster Dr. Jochen Franzen

GB 2 340 298

68/98 Family: TOF Owner: BFA Priority: 20.06.98 German Title: Me(beta)verfahren fur Polymorphismen und Mutationen in Nukleinsauren
English Titel: Methods of screening nucleic acids using mass spectrometry Inventors: Thomas Bonk Dr. Andreas Humeny Prof. Cord-Michael Prof. M. von Knebel Dr. Jochen Franzen

70/98 Family: XQ Owner: BFA Priority: 28.09.98 German Title: Verfahren zur Darstellung von Tochterionespektren der Ionenfallen-Massenspektrometrie
English Titel: Methods for library searches and extraction of structural information from daughter ion spectra in ion trap mass spectrometry Inventors: Dr. Jochen Franzen

BDAL.DE Patent Page 6


71/98 Family: DA Owner: BFA Priority: 28.09.98 German Title: Verfahren fur die interaktive Steuerung von Me(beta)- oder Auswerteverfahren in Chromatographie, Spektroskopie oder Elektrophorese English Titel: Method of using the mouse for interactive control in chromatography or spectroscopy
Inventors: Dr. Carsten Bassmann

*72/98 Family: XQ Owner: BFA Priority: 28.09.98 German Title: Verfahren zur Verwaltung von Tochterionen uber mehrere Generationen
English Titel: Method for management of daughter ion spectra over several generations
Inventors: Dr. Andreas Germanus

07/98 Family: TOF Owner: BSA Priority: 10.11.98 German Title: Einfache SNP-Analyse mittels Massenspektrometrie English Titel: Simple SNP analysis using mass spectrometry Inventors: Dr. Markus Kostrzewa Dr. Thomas Frohlich Dr. Thomas Wenzel

74/98 Family: TOF Owner: BDAL Priority: 30.11.98 German Title: Tochterionenspektren mit Flugzeitmassenspektrometern English Titel: Daughter ion spectra with time-of-flight mass spectrometers Inventors: Dr. Claus Koster Dr. Armin Holle Dr. Jochen Franzen

75/99 Family: TOF Owner: BDAL Priority: 27.01.99 German Title: Validierbare Punktmutationsanalyse mittels Massenspektrometrie English Titel:
Inventors: Dr. Ivo Gut Dr. Jochen Franzen

76/99 Family: ICR Owner: BDAL Priority: 12.03.99 German Title: Verfahren und Vorrichtung zur matrixunterstutzten Laserdesorptions-Ionisierung von Substanzen English Titel: A method and device for matrix assisted laser desorption ionization of substances
Inventors: Dr. Gokhan Baykut

77/99 Family: ICR Owner: BDAL Priority: 15.05.99 German Title: Verfahren und Vorrichtung zur Regelung der Ionenzahl in Ionenfallen-Massenspektrometern
English Titel:
Inventors: Dr. Gokhan Baykut Dr. Jochen Franzen


* This patent is used from time to time by parties to this agreement other than BDAL in connection with the use by such parties of BDAL's HyStar software.

BDAL.DE Patent Page 7


78/99 Family: TOF Owner: BDAL Priority: 16.05.99 German Title: Aufreinigende Probentrager fur die MALDI-Massenspektrometrie English Titel:
Inventors: Dr. Jochen Franzen

79/99 Family: TOF Owner: BDAL Priority: 30.06.99 German Title: Kopplung Dunnschicht-Chromatographie und Massenspektrometrie
(TLC/MS)
English Titel:
Inventors: Dr. F.-J. Mayer-Posner Dr. Jochen Franzen

*80/99 Family: XQ Owner: BDAL Priority: 01.07.99 German Title: Steuerung von Mess- und Auswerteverfahren mit der Computermaus English Titel:
Inventors: Rudiger Dreier Dr: Gerd Eden Dr. Jochen Franzen

81/99 Family: XQ Owner: BDAL Priority: 12.07.99 German Title: Fragmentierung in Quadrupol-Ionenfallenmassenspektrometern English Titel:
Inventors: Dr. Andeas Brekenfeld Dr. Michael Schubert Dr. Jochen Franzen

82/99 Family: ICR Owner: BDAL Priority: 03.08.99 German Title: Vorrichtung und Verfahren zum abwechselnden Betrieb mehrerer Ionenquellen
English Titel:
Inventors: Dr. Gokhan Baykut

83/99 Family: TOF Owner: BDAL Priority: 01.10.99 German Title: Kompaktes Reflektor-Flugzeitmassenspektrometer hochster Massenauflosung
English Titel:
Inventors: Dr. Armin Holle

84/99 Family: TOF Owner: BDAL Priority: 04.10.99 German Title: Prozessieren von Proben in Losung mit definiert kleiner Wandkontaktflache
English Titel:
Inventors: Dr. Martin Schurenberg Dr. Jochen Franzen Dr. Eckehard Nordhof Dr. Holger Eickhoff


* This patent is used from time to time by parties to this agreement other than BDAL in connection with the use by such parties of BDAL's HyStar software.

BDAL.DE Patent Page 8


85/99 Family: TOF Owner: BDAL Priority: 04.11.99 German Title: Kontaminationsfreie Ubertragung von Bioproben English Titel:
Inventors: Dr. Jochen Franzen

86/99 Family: TOF Owner: BDAL Priority: 10.12.99 German Title: Ionenselektor fur Tochterionenspektren in Flugzeitmassenspektrometern
English Titel:
Inventors: Platzhalter

87/99 Family: Owner: B+E Priority: 19.12.99 German Title: Massenspektrometrische Genotypisiserung des Gens MDR-1 English Titel:
Inventors: Platzhalter

88/00 Family: TOF Owner: BDAL Priority: 08.02.00 German Title: Gitterloses Reflektor-Flugzeitmassenspektrometer fur orthogonalen Ioneneinschuss
English Titel:
Inventors: Dr. Jochen Franzen

89/00 Family: TOF Owner: BDAL Priority: 27.02.00 German Title: Konditionierung eines Ionenstrahls fur den Einschuss in ein Flugzeitmassenspektrometer
English Titel:
Inventors: Dr. Jochen Franzen

90/00 Family: Owner: BDAL Priority: 06.03.00 German Title: Tandem-Massenspektrometer aus zwei Quadrupolfiltern English Titel:
Inventors: Dr. Jochen Franzen

BDAL.DE Patent Page 9


Exhibit 10.3

MALDI-TOF Mass Spectrometry

Collaboration and OEM Agreement

between

PerkinElmer Instruments LLC and its Affiliates ("PKI")

and

Bruker Daltonics Inc. and its Affiliates ("BDAL")

1. BACKGROUND

o PKI wishes to offer and distribute a MALDI-TOF system to its North American pharmaceutical, biotech, food and chemical industry customers, as well as to certain international markets by Q2-2000.

o PKI requires a high-quality MALDI-TOF for a diverse range of customer applications from a supplier with a strong reputation.

o PKI has particularly strong distribution channels into pharmaceutical and food QA/QC, pharma/biotech and chemical manufacturing, pharma/biotech drug development, pre-clinical and clinical trials.

o PKI also has international distribution strength in certain markets where BDAL is not well established, e.g. Latin America, Italy, Eastern Europe, Israel, India;

o If PKI rolls out a MALDI-TOF, it intends to sell such a product in significant numbers. Eventually, PKI wishes to sell such a product globally.

o Based on the performance, automation and quality of its systems, BDAL has recently become the leading MALDI-TOF company for high-end research applications in proteomics, PKIs, and drug discovery.

1

o BDAL has significant MALDI-TOF sales into universities, medical schools, government research labs, and pharma/biotech research and drug discovery labs.

o BDAL presently does not have strong distribution into industrial QA/QC, manufacturing, clinical trials, and drug development, and BDAL does not have complete international distribution coverage

o At Pittcon 2000, BDAL will introduce a high-performance, bench-top, PC/NT-driven MALDI-TOF system called OmniFLEXT(TM). This new product has very good performance/price ratio compared to otherbench-top MALDI-TOFs on the market. It is arguably "the first bench-top MALDI-TOF worth buying". The OmniFLEX also features an attractive industrial design, and a well thought-out intuitive GUI.

2. OBJECTIVE

PKI and BDAL wish to enter into a strategic alliance in MALDI-TOF mass spectrometry. In particular, PKI and BDAL wish to collaborate on the distribution of BDAL's linear bench-top OMNIFLEXTm MALDI-TOF system via PKI's international distribution system.

3. TERM AND NON-COMIPETE CLAUSE

Once signed by both parties this Agreement shall initially be valid until Dec. 31, 2001 ("Phase I"). If both PKI and BDAL are satisfied with Phase I of this Agreement, and if and when the numerical targets agreed to herein for Phase I have been reached, then this Agreement shall be automatically extended to Dec. 31st , 2003 ("Phase 2"). Thereafter, this Agreement is renewable for additional two-year periods by mutual written consent.

2

During the Term of this Agreement, and, except as described below, for one
(1) year following the expiration or termination of this Agreement, PKI will not develop, manufacture, offer to sell, sell or deliver any other benchtop MALDI-TOF system comparable to the OmniFLEX, i.e. in the selling price range between $80,000 to $140,000, and not built by BDAL, unless BDAL cannot deliver systems without sustained, substantial and non-solvable delivery or quality problems which negatively impact PKI's ability to sell the OmniFLEX.

Any MALDI-TOF system manufactured and/or sold by Genomic Solutions Inc. as part of a complete proteomics solution (presently called Investigator(TM) proteomics solution) via PKI or other sales channels shall be specifically excluded from this non-compete clause. Also, this non-compete clause shall not apply if PKI acquires an instrument company with a MALDI-TOF product line if that line represents less than 30% of the acquired company's business. Finally, this non-compete clause shall not apply if BDAL is not willing to sell and deliver OmniFLEX systems to PKI, for example by refusing to extend this Collaboration into a Phase 2 (see below), even though PKI may have achieved the minimum quantities of Phase I (see below).

4. PRODUCT DEFINITION & CO-LABELLING

The mass spectrometer that may be resold by PKI as an authorized OEM-dealer for BDAL is a linear OMNIFLEX(TM) MALDI-TOF, as described in Attachment A, which will meet the specifications contained in Attachment B. PKI may also resell additional BDAL MALDI-TOF accessories, such as MAP(TM) MALDI AutoPrep robots, AnchorChip(TM) high-sensitivity targets, various post-processing software packages, and MALDI-TOF consumables (collectively the "Accessories"), which are described on

3

BDAL's standard U.S. MALDI-TOF price list from time to time. The linear OmniFLEX system to be sold by PKI will be co-labeled with both, equally-sized PKI and BDAL decals on the system.

If, during the term of this Agreement BDAL introduces a system that replaces or supersedes the OmniFLEX or introduces new Accessories, BDAL will sell such products to PKI under the terms of this Agreement.

PKI is specifically not authorized to sell the reflector version of the OmniFLEX. If a research customer absolutely needs a reflector OmniFLEX system from the beginning, then PKI will pass this customer lead on to BDAL. The only exception to this policy is that PKI upon specific request by its linear OmniFLEX customer, may sell the reflector upgrade to PKI linear OmniFLEX customers who have accepted their PKI-purchased linear OnmiFLEX more than twelve
(12) months before those customers request an upgrade. The transfer price to PKI will be the BDAL U.S. list price minus a 10% finders' fee for PKI. BDAL will install the reflector upgrade, and provide a limited 90-day warranty on the reflector upgrade. Moreover, PKI agrees not to incentivize its sales force or product manager for reflectron upgrades sold via PKI to its customer base of linear OmniFLEX customers.

For customer leads passed from PKI to BDAL which result in an accepted purchase order for a reflectron OmniFLEX, or a reflectron upgrade, to BDAL, BDAL will pay PKI a 5% finder's fee of the purchase order net amount, provided that PKI played a significant and substantial role in assisting BDAL with the systems sale (i.e. this would apply if a joint sales call took place, but it would not apply for passing on lists of potential customers, unqualified general leads, etc.).

4

It is understood that BDAL itself will also continue to sell the OmniFLEX, including a version with an optional reflector, and nothing contained in this Agreement shall prevent BDAL from selling or distributing its OmniFLEX system also via additional third-party distribution channels in the future.

PKI and BDAL agree that on-time deliveries and high quality are important for the success of this Collaboration. If repeated substantially late deliveries and major quality problems arise, PKI and BDAL will try to resolve these issues mutually. If BDAL cannot deliver OmniFLEX systems to PKI without sustained, substantial and non-solvable delivery or quality problems which negatively impact PKI's ability to sell the OmniFLEX, then PKI can terminate this Agreement with one hundred twenty (120) days written notice, including a ninety (90) day period during which BDAL is afforded an opportunity to fix the delivery or quality problems.

5. INTRODUCTION AND PHASE 1

PKI and BDAL intend to announce their strategic alliance and simultaneously introduce the OmniFLEX at Pittcon 2000 on March 13th, 2000. BDAL will loan an OmniFLEX shell or system to PKI for Pittcon 2000. If PKI can provide paint color requests and decals to BDAL very soon, then BDAL will make a best effort to have a co-labeled OmniFLEX shell or system in the PKI selected colors at the PKI booth at Pittcon.

This strategic alliance will be announced in a joint mutually agreeable pre